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Prevalence of radiographic hip osteoporosis is increased in high bone mass

Prevalence of radiographic hip osteoporosis is increased in high bone mass
Prevalence of radiographic hip osteoporosis is increased in high bone mass
Objective: to examine the cross-sectional association between radiographic features of hip osteoarthritis (OA) and bone mineral density (BMD) of the hip, spine, and appendicular skeleton among Caucasian women ages 65 and older who were participating in the Study of Osteoporotic Fractures.

Methods: pelvis radiographs of 4,855 subjects were assessed for individual radiographic features of hip OA: osteophytes, joint space narrowing, subchondral sclerosis, cysts, and femoral head deformity. Hips were graded on a summary scale of 0 (no OA) to 4 (severe OA) based on the number of radiographic features present. Appendicular BMD was measured in all subjects, and hip and spine BMD in 84% of the group. We used linear regression to examine the association of BMD with hip OA, and to adjust for age, weight, and other determinants of bone mass.

Results: three hundred fifty-one women (7.2%) had mild (grade 2) and 228 (4.7%) had moderate to severe (grade 3–4) radiographic evidence of hip OA. Women with grade 3–4 hip OA had a higher age-adjusted BMD at the femoral neck and Ward's triangle (9–10%; P < 0.0001), trochanter (4%; P < 0.01), lumbar spine (8%; P < 0.0001), and distal radius and calcaneus (5%; P < 0.0001 [for each comparison]) compared with those with grade 0–1 OA in the worse hip. Elevations in BMD were greatest in the femoral neck of hips with OA, in women with bilateral hip OA, and in women with hip osteophytes. These findings were essentially unchanged by adjustment for determinants of bone mass.

Conclusion: elderly Caucasian women with moderate to severe radiographic hip OA had higher BMD in the hip, spine, and appendicular skeleton than did women without hip OA. Our findings are consistent with a role of elevated BMD in the pathogenesis of hip OA
1063-4584
1120-1128
Hardcastle, S.A.
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Dieppe, P.
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Gregson, C.L.
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Hunter, D.
c92c57bd-661e-44ce-81c2-3668494ba672
Thomas, G.E.
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Arden, N.K.
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Spector, T.D.
87d1f285-3f22-4c9a-b006-d65cfda6d3e0
Hart, D.J.
00e78191-ce14-4b5f-a720-9f1bb51b2b62
Laugharne, M.J.
6d035ea7-d08d-432d-8c86-dd169e33636d
Clague, G.A.
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Edwards, M.H.
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Dennison, E.M.
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Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Williams, M.
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Davey, S.G.
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Tobias, J.H.
de2ae2cb-8547-475a-98e0-9d5169b8deb7
Hardcastle, S.A.
5d3e434f-9f5c-4044-8f6e-753fa8748cde
Dieppe, P.
293f54b1-2f1a-4dd1-ad56-88ab75dab64e
Gregson, C.L.
fc84c2dd-c427-486f-a212-3e3549cb5cdf
Hunter, D.
c92c57bd-661e-44ce-81c2-3668494ba672
Thomas, G.E.
af927412-354d-4400-a6af-ca9743e8639f
Arden, N.K.
23af958d-835c-4d79-be54-4bbe4c68077f
Spector, T.D.
87d1f285-3f22-4c9a-b006-d65cfda6d3e0
Hart, D.J.
00e78191-ce14-4b5f-a720-9f1bb51b2b62
Laugharne, M.J.
6d035ea7-d08d-432d-8c86-dd169e33636d
Clague, G.A.
bba3a3af-f41a-4935-b7aa-5fc634dc7a5f
Edwards, M.H.
b81ff294-1d16-4a1b-af14-9374c5989d4c
Dennison, E.M.
ee647287-edb4-4392-8361-e59fd505b1d1
Cooper, C.
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Williams, M.
cb14ede8-6813-493f-870b-e0cc586f3b90
Davey, S.G.
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Tobias, J.H.
de2ae2cb-8547-475a-98e0-9d5169b8deb7

Hardcastle, S.A., Dieppe, P., Gregson, C.L., Hunter, D., Thomas, G.E., Arden, N.K., Spector, T.D., Hart, D.J., Laugharne, M.J., Clague, G.A., Edwards, M.H., Dennison, E.M., Cooper, C., Williams, M., Davey, S.G. and Tobias, J.H. (2014) Prevalence of radiographic hip osteoporosis is increased in high bone mass. Osteoarthritis and Cartilage, 22 (8), 1120-1128. (doi:10.1016/j.joca.2014.06.007). (PMID:24971870)

Record type: Article

Abstract

Objective: to examine the cross-sectional association between radiographic features of hip osteoarthritis (OA) and bone mineral density (BMD) of the hip, spine, and appendicular skeleton among Caucasian women ages 65 and older who were participating in the Study of Osteoporotic Fractures.

Methods: pelvis radiographs of 4,855 subjects were assessed for individual radiographic features of hip OA: osteophytes, joint space narrowing, subchondral sclerosis, cysts, and femoral head deformity. Hips were graded on a summary scale of 0 (no OA) to 4 (severe OA) based on the number of radiographic features present. Appendicular BMD was measured in all subjects, and hip and spine BMD in 84% of the group. We used linear regression to examine the association of BMD with hip OA, and to adjust for age, weight, and other determinants of bone mass.

Results: three hundred fifty-one women (7.2%) had mild (grade 2) and 228 (4.7%) had moderate to severe (grade 3–4) radiographic evidence of hip OA. Women with grade 3–4 hip OA had a higher age-adjusted BMD at the femoral neck and Ward's triangle (9–10%; P < 0.0001), trochanter (4%; P < 0.01), lumbar spine (8%; P < 0.0001), and distal radius and calcaneus (5%; P < 0.0001 [for each comparison]) compared with those with grade 0–1 OA in the worse hip. Elevations in BMD were greatest in the femoral neck of hips with OA, in women with bilateral hip OA, and in women with hip osteophytes. These findings were essentially unchanged by adjustment for determinants of bone mass.

Conclusion: elderly Caucasian women with moderate to severe radiographic hip OA had higher BMD in the hip, spine, and appendicular skeleton than did women without hip OA. Our findings are consistent with a role of elevated BMD in the pathogenesis of hip OA

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Published date: August 2014
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 370209
URI: http://eprints.soton.ac.uk/id/eprint/370209
ISSN: 1063-4584
PURE UUID: 9ba76604-73ad-40c3-aa8e-fc17f896e1fa
ORCID for E.M. Dennison: ORCID iD orcid.org/0000-0002-3048-4961
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

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Date deposited: 24 Oct 2014 13:38
Last modified: 18 Mar 2024 02:45

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Contributors

Author: S.A. Hardcastle
Author: P. Dieppe
Author: C.L. Gregson
Author: D. Hunter
Author: G.E. Thomas
Author: N.K. Arden
Author: T.D. Spector
Author: D.J. Hart
Author: M.J. Laugharne
Author: G.A. Clague
Author: M.H. Edwards
Author: E.M. Dennison ORCID iD
Author: C. Cooper ORCID iD
Author: M. Williams
Author: S.G. Davey
Author: J.H. Tobias

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