Primary cutaneous nodular amyloidosis associated with psoriasis
Primary cutaneous nodular amyloidosis associated with psoriasis
Primary cutaneous nodular amyloidosis (PCNA) presents as solitary or multiple firm, waxy nodules with a predilection for acral areas. Histologically, PCNA can be identical to myeloma-associated systemic amyloidosis with monoclonal immunoglobulin light chain deposits. We describe a patient in whom PCNA developed in a scar in an area affected by chronic plaque psoriasis. PCNA has previously been associated with other autoimmune diseases, but to our knowledge, this is the first association with psoriasis. Interestingly, T helper (Th)17 cells, which are crucial in psoriasis pathogenesis, have recently been implicated in promotion of myeloma and plasma cell dyscrasias. The association of psoriasis and plasma-cell light chain production in the skin, as in this case, suggests a possible role for Th17 cells in PCNA formation. The dermatopathological literature of this rare but important disease is discussed.
608-611
Ung, C.Y.
e53a9511-f3ad-4256-8bcf-b6687d15bf57
Carr, N.J.
50cba895-662a-4e10-aee1-e1bb131e1c7a
Ardern-Jones, M.R.
7ac43c24-94ab-4d19-ba69-afaa546bec90
July 2014
Ung, C.Y.
e53a9511-f3ad-4256-8bcf-b6687d15bf57
Carr, N.J.
50cba895-662a-4e10-aee1-e1bb131e1c7a
Ardern-Jones, M.R.
7ac43c24-94ab-4d19-ba69-afaa546bec90
Ung, C.Y., Carr, N.J. and Ardern-Jones, M.R.
(2014)
Primary cutaneous nodular amyloidosis associated with psoriasis.
Clinical and Experimental Dermatology, 39 (5), .
(doi:10.1111/ced.12347).
(PMID:24888341)
Abstract
Primary cutaneous nodular amyloidosis (PCNA) presents as solitary or multiple firm, waxy nodules with a predilection for acral areas. Histologically, PCNA can be identical to myeloma-associated systemic amyloidosis with monoclonal immunoglobulin light chain deposits. We describe a patient in whom PCNA developed in a scar in an area affected by chronic plaque psoriasis. PCNA has previously been associated with other autoimmune diseases, but to our knowledge, this is the first association with psoriasis. Interestingly, T helper (Th)17 cells, which are crucial in psoriasis pathogenesis, have recently been implicated in promotion of myeloma and plasma cell dyscrasias. The association of psoriasis and plasma-cell light chain production in the skin, as in this case, suggests a possible role for Th17 cells in PCNA formation. The dermatopathological literature of this rare but important disease is discussed.
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e-pub ahead of print date: 29 May 2014
Published date: July 2014
Organisations:
Clinical & Experimental Sciences
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Local EPrints ID: 370233
URI: http://eprints.soton.ac.uk/id/eprint/370233
ISSN: 0307-6938
PURE UUID: 85946d8f-0c81-48ab-acfb-3aa0c1ad9edb
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Date deposited: 27 Oct 2014 11:28
Last modified: 15 Mar 2024 03:28
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Author:
C.Y. Ung
Author:
N.J. Carr
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