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Primary cutaneous nodular amyloidosis associated with psoriasis

Primary cutaneous nodular amyloidosis associated with psoriasis
Primary cutaneous nodular amyloidosis associated with psoriasis
Primary cutaneous nodular amyloidosis (PCNA) presents as solitary or multiple firm, waxy nodules with a predilection for acral areas. Histologically, PCNA can be identical to myeloma-associated systemic amyloidosis with monoclonal immunoglobulin light chain deposits. We describe a patient in whom PCNA developed in a scar in an area affected by chronic plaque psoriasis. PCNA has previously been associated with other autoimmune diseases, but to our knowledge, this is the first association with psoriasis. Interestingly, T helper (Th)17 cells, which are crucial in psoriasis pathogenesis, have recently been implicated in promotion of myeloma and plasma cell dyscrasias. The association of psoriasis and plasma-cell light chain production in the skin, as in this case, suggests a possible role for Th17 cells in PCNA formation. The dermatopathological literature of this rare but important disease is discussed.
0307-6938
608-611
Ung, C.Y.
e53a9511-f3ad-4256-8bcf-b6687d15bf57
Carr, N.J.
50cba895-662a-4e10-aee1-e1bb131e1c7a
Ardern-Jones, M.R.
7ac43c24-94ab-4d19-ba69-afaa546bec90
Ung, C.Y.
e53a9511-f3ad-4256-8bcf-b6687d15bf57
Carr, N.J.
50cba895-662a-4e10-aee1-e1bb131e1c7a
Ardern-Jones, M.R.
7ac43c24-94ab-4d19-ba69-afaa546bec90

Ung, C.Y., Carr, N.J. and Ardern-Jones, M.R. (2014) Primary cutaneous nodular amyloidosis associated with psoriasis. Clinical and Experimental Dermatology, 39 (5), 608-611. (doi:10.1111/ced.12347). (PMID:24888341)

Record type: Article

Abstract

Primary cutaneous nodular amyloidosis (PCNA) presents as solitary or multiple firm, waxy nodules with a predilection for acral areas. Histologically, PCNA can be identical to myeloma-associated systemic amyloidosis with monoclonal immunoglobulin light chain deposits. We describe a patient in whom PCNA developed in a scar in an area affected by chronic plaque psoriasis. PCNA has previously been associated with other autoimmune diseases, but to our knowledge, this is the first association with psoriasis. Interestingly, T helper (Th)17 cells, which are crucial in psoriasis pathogenesis, have recently been implicated in promotion of myeloma and plasma cell dyscrasias. The association of psoriasis and plasma-cell light chain production in the skin, as in this case, suggests a possible role for Th17 cells in PCNA formation. The dermatopathological literature of this rare but important disease is discussed.

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More information

e-pub ahead of print date: 29 May 2014
Published date: July 2014
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 370233
URI: https://eprints.soton.ac.uk/id/eprint/370233
ISSN: 0307-6938
PURE UUID: 85946d8f-0c81-48ab-acfb-3aa0c1ad9edb

Catalogue record

Date deposited: 27 Oct 2014 11:28
Last modified: 17 Jul 2017 21:52

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