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Does nonspecific bronchial responsiveness indicate the severity of asthma?

Does nonspecific bronchial responsiveness indicate the severity of asthma?
Does nonspecific bronchial responsiveness indicate the severity of asthma?
It is difficult to analyse the relationship between bronchial responsiveness and the severity of asthma since each alone is difficult to assess. Asthma is a heterogeneous condition with many patterns of expression, and clinical methods used to assess its severity have their limitations. Problems also arise in interpreting the results of bronchial provocation tests and methodological differences make comparisons between studies difficult. The findings of both cross-sectional and longitudinal studies have shown a general relationship between the degree of responsiveness and the severity of asthma, but within subjects the relationship is weaker. A greater understanding must await increased knowledge of the mechanisms underlying asthma and the contribution which hyperresponsiveness makes to each of these.
0903-1936
220-227
Josephs, Lynn K.
865f1878-f0ca-42c3-a030-df6dcbc705b0
Gregg, I.
2976ca7e-54e7-4bb3-b0b2-1e47500a8c50
Holgate, S.T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Josephs, Lynn K.
865f1878-f0ca-42c3-a030-df6dcbc705b0
Gregg, I.
2976ca7e-54e7-4bb3-b0b2-1e47500a8c50
Holgate, S.T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc

Josephs, Lynn K., Gregg, I. and Holgate, S.T. (1990) Does nonspecific bronchial responsiveness indicate the severity of asthma? European Respiratory Journal, 3 (2), 220-227. (PMID:2178967)

Record type: Article

Abstract

It is difficult to analyse the relationship between bronchial responsiveness and the severity of asthma since each alone is difficult to assess. Asthma is a heterogeneous condition with many patterns of expression, and clinical methods used to assess its severity have their limitations. Problems also arise in interpreting the results of bronchial provocation tests and methodological differences make comparisons between studies difficult. The findings of both cross-sectional and longitudinal studies have shown a general relationship between the degree of responsiveness and the severity of asthma, but within subjects the relationship is weaker. A greater understanding must await increased knowledge of the mechanisms underlying asthma and the contribution which hyperresponsiveness makes to each of these.

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Published date: February 1990
Organisations: Primary Care & Population Sciences

Identifiers

Local EPrints ID: 370371
URI: https://eprints.soton.ac.uk/id/eprint/370371
ISSN: 0903-1936
PURE UUID: 8858323e-3b52-41b4-8f21-792498220a02

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Date deposited: 29 Oct 2014 12:07
Last modified: 17 Jul 2017 21:51

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