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Ultraviolet radiation suppresses obesity and symptoms of metabolic syndrome independently of vitamin d in mice fed a high-fat diet.

Geldenhuys, Sian, Hart, Prue H., Endersby, Raelene, Jacoby, Peter, Feelisch, Martin, Weller, Richard B., Matthews, Vance and Gorman, Shelley (2014) Ultraviolet radiation suppresses obesity and symptoms of metabolic syndrome independently of vitamin d in mice fed a high-fat diet. Diabetes, 63, (11), pp. 3759-3769. (PMID:25342734).

Record type: Article

Abstract

The role of vitamin D in curtailing the development of obesity and comorbidities such as the metabolic syndrome (MetS) and type 2 diabetes has received much attention recently. However, clinical trials have failed to conclusively demonstrate the benefits of vitamin D supplementation. In most studies, serum 25-hydroxyvitamin D [25(OH)D] decreases with increasing BMI above normal weight. These low 25(OH)D levels may also be a proxy for reduced exposure to sunlight-derived ultraviolet radiation (UVR). Here we investigate whether UVR and/or vitamin D supplementation modifies the development of obesity and type 2 diabetes in a murine model of obesity. Long-term suberythemal and erythemal UVR significantly suppressed weight gain, glucose intolerance, insulin resistance, nonalcoholic fatty liver disease measures; and serum levels of fasting insulin, glucose, and cholesterol in C57BL/6 male mice fed a high-fat diet. However, many of the benefits of UVR were not reproduced by vitamin D supplementation. In further mechanistic studies, skin induction of the UVR-induced mediator nitric oxide (NO) reproduced many of the effects of UVR. These studies suggest that UVR (sunlight exposure) may be an effective means of suppressing the development of obesity and MetS, through mechanisms that are independent of vitamin D but dependent on other UVR-induced mediators such as NO.

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More information

Published date: November 2014
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 370461
URI: http://eprints.soton.ac.uk/id/eprint/370461
ISSN: 0012-1797
PURE UUID: f0fa2378-fd3d-4857-86d2-05c1e148a671
ORCID for Martin Feelisch: ORCID iD orcid.org/0000-0003-2320-1158

Catalogue record

Date deposited: 29 Oct 2014 13:22
Last modified: 30 Sep 2017 16:01

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Contributors

Author: Sian Geldenhuys
Author: Prue H. Hart
Author: Raelene Endersby
Author: Peter Jacoby
Author: Martin Feelisch ORCID iD
Author: Richard B. Weller
Author: Vance Matthews
Author: Shelley Gorman

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