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Crystallization of amorphous lactose at high humidity studied by terahertz time domain spectroscopy

Crystallization of amorphous lactose at high humidity studied by terahertz time domain spectroscopy
Crystallization of amorphous lactose at high humidity studied by terahertz time domain spectroscopy
We report the first use of terahertz time-domain spectroscopy (THz-TDS) to study the hydration and crystallization of an amorphous molecular solid at high humidity. Lactose in its amorphous and monohydrate forms exhibits different terahertz spectra due to the lack of long range order in the amorphous material. This difference allowed the transformation of amorphous lactose to its monohydrate form at high humidity to be studied in real time. Spectral fitting of frequency-domain data allowed kinetic data to be obtained and the crystallization was found to obey Avrami kinetics. Bulk changes during the crystallization could also be observed in the time-domain.
0009-2614
104-108
McIntosh, Alexander I.
c80db335-fd7f-4b8e-b483-39ed85d833ed
Yang, Bin
4ba4d94d-6684-4160-a496-083fec9c3f8a
Goldup, Stephen M.
0a93eedd-98bb-42c1-a963-e2815665e937
Watkinson, Michael
7405d50a-0e9d-4b31-8e23-0a3198eb1abd
Donnan, Robert S.
28d0f65f-7487-4789-b234-d6da8e20af72
McIntosh, Alexander I.
c80db335-fd7f-4b8e-b483-39ed85d833ed
Yang, Bin
4ba4d94d-6684-4160-a496-083fec9c3f8a
Goldup, Stephen M.
0a93eedd-98bb-42c1-a963-e2815665e937
Watkinson, Michael
7405d50a-0e9d-4b31-8e23-0a3198eb1abd
Donnan, Robert S.
28d0f65f-7487-4789-b234-d6da8e20af72

McIntosh, Alexander I., Yang, Bin, Goldup, Stephen M., Watkinson, Michael and Donnan, Robert S. (2013) Crystallization of amorphous lactose at high humidity studied by terahertz time domain spectroscopy. Chemical Physics Letters, 558, 104-108. (doi:10.1016/j.cplett.2012.12.044).

Record type: Article

Abstract

We report the first use of terahertz time-domain spectroscopy (THz-TDS) to study the hydration and crystallization of an amorphous molecular solid at high humidity. Lactose in its amorphous and monohydrate forms exhibits different terahertz spectra due to the lack of long range order in the amorphous material. This difference allowed the transformation of amorphous lactose to its monohydrate form at high humidity to be studied in real time. Spectral fitting of frequency-domain data allowed kinetic data to be obtained and the crystallization was found to obey Avrami kinetics. Bulk changes during the crystallization could also be observed in the time-domain.

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More information

Published date: 12 February 2013
Organisations: Organic Chemistry: Synthesis, Catalysis and Flow

Identifiers

Local EPrints ID: 370651
URI: http://eprints.soton.ac.uk/id/eprint/370651
DOI: doi:10.1016/j.cplett.2012.12.044
ISSN: 0009-2614
PURE UUID: edf44ca8-3afb-40f8-88ac-eb3fd1af7f0e
ORCID for Stephen M. Goldup: ORCID iD orcid.org/0000-0003-3781-0464

Catalogue record

Date deposited: 03 Nov 2014 13:03
Last modified: 14 Mar 2024 18:19

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Contributors

Author: Alexander I. McIntosh
Author: Bin Yang
Author: Stephen M. Goldup ORCID iD
Author: Michael Watkinson
Author: Robert S. Donnan

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