Active-metal template synthesis of a molecular trefoil knot

Barran, Perdita E., Cole, Harriet L., Goldup, Stephen M., Leigh, David A., McGonigal, Paul R., Symes, Mark D., Wu, Jhenyi and Zengerle, Michael (2011) Active-metal template synthesis of a molecular trefoil knot. Angewandte Chemie International Edition, 50 (51), 12280-12284. (doi:10.1002/anie.201105012). (PMID:21919173)

Abstract

Tying the knot: The marriage of catalysis and coordination chemistry enables two CuI ions (red; see picture) to work in partnership for the synthesis of a molecular trefoil knot. One ion entangles an acyclic building block to create a loop in the ligand, and the other gathers the ligand's reactive end-groups, threads the loop, and catalyzes the covalent capture of the knotted architecture by an alkyne–azide “click” reaction.

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Contributors

Author: Stephen M. Goldup

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