A simple, short, and flexible synthesis of viridiofungin derivatives

Goldup, Stephen M., Pilkington, Christopher J., White, Andrew J.P., Burton, Andrew and Barrett, Anthony G.M. (2006) A simple, short, and flexible synthesis of viridiofungin derivatives. Journal of Organic Chemistry, 71 (16), 6185-6191. (doi:10.1021/jo060931e).

Abstract

Described herein is a simple, flexible, and efficient synthesis of the skeleton of the viridiofungins, a family of microbial secondary metabolites. The synthesis utilizes an asymmetric aldol reaction of a chiral oxazolidinone, a diastereoselective alkylation of a chiral 1,3-dioxolan-2-one, and a geometrically selective alkene cross-metathesis reaction as the key C?C bond-forming steps

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