The University of Southampton
University of Southampton Institutional Repository

Neural correlates of tinnitus related distress: an fMRI-study

Neural correlates of tinnitus related distress: an fMRI-study
Neural correlates of tinnitus related distress: an fMRI-study
Chronic tinnitus affects approximately 5% of the population. Severe distress due to the phantom noise is experienced by 20% of the tinnitus patients. This distress cannot be predicted by psychoacoustic features of the tinnitus. It is commonly assumed that negative cognitive emotional evaluation of the tinnitus and its expected consequences is a major factor that determines the impact of tinnitus-related distress. Models of tinnitus distress and recently conducted research propose differences in limbic, frontal and parietal processing between highly and low distressed tinnitus patients. An experimental paradigm using verbal material to stimulate cognitive emotional processing of tinnitus-related information was conducted. Age and sex matched highly (n = 16) and low (n = 16) distressed tinnitus patients and healthy controls (n = 16) underwent functional magnetic resonance imaging (fMRI) while sentences with neutral, negative or tinnitus-related content were presented. A random effects group analysis was performed on the basis of the general linear model. Tinnitus patients showed stronger activations to tinnitus-related sentences in comparison to neutral sentences than healthy controls in various limbic/emotion processing areas, such as the anterior cingulate cortex, midcingulate cortex, posterior cingulate cortex, retrosplenial cortex and insula and also in frontal areas. Highly and low distressed tinnitus patients differed in terms of activation of the left middle frontal gyrus. A connectivity analysis and correlational analysis between the predictors of the general linear model of relevant contrasts and tinnitus-related distress further supported the idea of a fronto-parietal-cingulate network, which seems to be more active in highly distressed tinnitus patients. This network may present an aspecific distress network. Based on the findings the left middle frontal gyrus and the right medial frontal gyrus are suggested as target regions for neuromodulatory approaches in the treatment of tinnitus. For future studies we recommend the use of idiosyncratic stimulus material.
0378-5955
87-99
Golm, Dennis
ae337f61-561e-4d44-9cf3-3e5611c7b484
Schmidt-Samoa, Carsten
1aa16c73-39a9-4c49-9649-a070188aadb2
Dechent, Peter
49dd2340-aded-43a3-9cf8-9f917da2bbde
Kröner-Herwig, Birgit
abd298a8-39a5-4fe1-b5c1-4ed294531fed
Golm, Dennis
ae337f61-561e-4d44-9cf3-3e5611c7b484
Schmidt-Samoa, Carsten
1aa16c73-39a9-4c49-9649-a070188aadb2
Dechent, Peter
49dd2340-aded-43a3-9cf8-9f917da2bbde
Kröner-Herwig, Birgit
abd298a8-39a5-4fe1-b5c1-4ed294531fed

Golm, Dennis, Schmidt-Samoa, Carsten, Dechent, Peter and Kröner-Herwig, Birgit (2013) Neural correlates of tinnitus related distress: an fMRI-study. Hearing Research, 295, 87-99. (doi:10.1016/j.heares.2012.03.003). (PMID:22445697)

Record type: Article

Abstract

Chronic tinnitus affects approximately 5% of the population. Severe distress due to the phantom noise is experienced by 20% of the tinnitus patients. This distress cannot be predicted by psychoacoustic features of the tinnitus. It is commonly assumed that negative cognitive emotional evaluation of the tinnitus and its expected consequences is a major factor that determines the impact of tinnitus-related distress. Models of tinnitus distress and recently conducted research propose differences in limbic, frontal and parietal processing between highly and low distressed tinnitus patients. An experimental paradigm using verbal material to stimulate cognitive emotional processing of tinnitus-related information was conducted. Age and sex matched highly (n = 16) and low (n = 16) distressed tinnitus patients and healthy controls (n = 16) underwent functional magnetic resonance imaging (fMRI) while sentences with neutral, negative or tinnitus-related content were presented. A random effects group analysis was performed on the basis of the general linear model. Tinnitus patients showed stronger activations to tinnitus-related sentences in comparison to neutral sentences than healthy controls in various limbic/emotion processing areas, such as the anterior cingulate cortex, midcingulate cortex, posterior cingulate cortex, retrosplenial cortex and insula and also in frontal areas. Highly and low distressed tinnitus patients differed in terms of activation of the left middle frontal gyrus. A connectivity analysis and correlational analysis between the predictors of the general linear model of relevant contrasts and tinnitus-related distress further supported the idea of a fronto-parietal-cingulate network, which seems to be more active in highly distressed tinnitus patients. This network may present an aspecific distress network. Based on the findings the left middle frontal gyrus and the right medial frontal gyrus are suggested as target regions for neuromodulatory approaches in the treatment of tinnitus. For future studies we recommend the use of idiosyncratic stimulus material.

Text
Golm_2016_Tinnitus_Stroop.pdf - Other
Download (1MB)

More information

e-pub ahead of print date: 14 March 2012
Published date: January 2013
Organisations: Psychology

Identifiers

Local EPrints ID: 371628
URI: http://eprints.soton.ac.uk/id/eprint/371628
ISSN: 0378-5955
PURE UUID: 32ad4fa6-0ca2-48a4-ba5d-af5598009f7d
ORCID for Dennis Golm: ORCID iD orcid.org/0000-0002-2950-7935

Catalogue record

Date deposited: 10 Nov 2014 14:25
Last modified: 15 Mar 2024 03:49

Export record

Altmetrics

Contributors

Author: Dennis Golm ORCID iD
Author: Carsten Schmidt-Samoa
Author: Peter Dechent
Author: Birgit Kröner-Herwig

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×