HIF-1 promotes the expression of its ?-subunit via an epigenetically regulated transactivation loop
HIF-1 promotes the expression of its ?-subunit via an epigenetically regulated transactivation loop
Hypoxia inducible factor-1 (HIF-1) directs the cellular response to low oxygen and plays a key role in tumour survival and growth. Here we use an inhibitor of the HIF-1?/HIF-1? protein-protein interaction to show the presence of an epigenetically controlled transactivation loop whereby the HIF-1 transcription factor promotes the expression of its own ?-subunit in hypoxic cancer cells.
2505-2508
Asby, Daniel J.
cf0462d7-e923-45eb-b4ce-7c1673f544d5
Cuda, F.
8c738a55-70a8-4063-b063-bf83cdf0f270
Hoakwie, Franciane
be6ab35d-4511-45ae-b059-32ae7b4236af
Miranda, Elena
ad727f7b-cc62-4904-b46d-043f74ef88ed
Tavassoli, Ali
d561cf8f-2669-46b5-b6e1-2016c85d63b2
29 July 2014
Asby, Daniel J.
cf0462d7-e923-45eb-b4ce-7c1673f544d5
Cuda, F.
8c738a55-70a8-4063-b063-bf83cdf0f270
Hoakwie, Franciane
be6ab35d-4511-45ae-b059-32ae7b4236af
Miranda, Elena
ad727f7b-cc62-4904-b46d-043f74ef88ed
Tavassoli, Ali
d561cf8f-2669-46b5-b6e1-2016c85d63b2
Asby, Daniel J., Cuda, F., Hoakwie, Franciane, Miranda, Elena and Tavassoli, Ali
(2014)
HIF-1 promotes the expression of its ?-subunit via an epigenetically regulated transactivation loop.
Molecular BioSystems, 10 (10), .
(doi:10.1039/C4MB00351A).
(PMID:25091694)
Abstract
Hypoxia inducible factor-1 (HIF-1) directs the cellular response to low oxygen and plays a key role in tumour survival and growth. Here we use an inhibitor of the HIF-1?/HIF-1? protein-protein interaction to show the presence of an epigenetically controlled transactivation loop whereby the HIF-1 transcription factor promotes the expression of its own ?-subunit in hypoxic cancer cells.
This record has no associated files available for download.
More information
e-pub ahead of print date: 2014
Published date: 29 July 2014
Organisations:
Organic Chemistry: SCF
Identifiers
Local EPrints ID: 371642
URI: http://eprints.soton.ac.uk/id/eprint/371642
ISSN: 1742-2051
PURE UUID: de8ed6a7-ef68-49da-a046-e610959d189c
Catalogue record
Date deposited: 11 Nov 2014 11:27
Last modified: 15 Mar 2024 03:26
Export record
Altmetrics
Contributors
Author:
Daniel J. Asby
Author:
F. Cuda
Author:
Franciane Hoakwie
Author:
Elena Miranda
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
