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Peptides come round: using SICLOPPS libraries for early stage drug discovery

Peptides come round: using SICLOPPS libraries for early stage drug discovery
Peptides come round: using SICLOPPS libraries for early stage drug discovery
Cyclic peptides are an emerging class of molecular therapeutics that are increasingly viewed as ideal backbones for modulation of protein-protein interactions. A split-intein based method, termed SICLOPPS, enables the rapid generation of genetically encoded cyclic peptide libraries of around a hundred million members. Here we review recent approaches using SICLOPPS for the discovery of bioactive compounds.
cyclic peptides, drug discovery, high throughput screening, medicinal chemistry, protein–protein interactions
0947-6539
10608-10614
Lennard, Katherine
1ddd5215-8af1-4654-ac6e-f6ff308403da
Tavassoli, Ali
d561cf8f-2669-46b5-b6e1-2016c85d63b2
Lennard, Katherine
1ddd5215-8af1-4654-ac6e-f6ff308403da
Tavassoli, Ali
d561cf8f-2669-46b5-b6e1-2016c85d63b2

Lennard, Katherine and Tavassoli, Ali (2014) Peptides come round: using SICLOPPS libraries for early stage drug discovery. Chemistry - A European Journal, 20 (34), 10608-10614. (doi:10.1002/chem.201403117). (PMID:25043886)

Record type: Article

Abstract

Cyclic peptides are an emerging class of molecular therapeutics that are increasingly viewed as ideal backbones for modulation of protein-protein interactions. A split-intein based method, termed SICLOPPS, enables the rapid generation of genetically encoded cyclic peptide libraries of around a hundred million members. Here we review recent approaches using SICLOPPS for the discovery of bioactive compounds.

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More information

Published date: 18 August 2014
Keywords: cyclic peptides, drug discovery, high throughput screening, medicinal chemistry, protein–protein interactions
Organisations: Organic Chemistry: SCF

Identifiers

Local EPrints ID: 371644
URI: http://eprints.soton.ac.uk/id/eprint/371644
DOI: doi:10.1002/chem.201403117
ISSN: 0947-6539
PURE UUID: 1eac6d9e-b166-4c78-a86f-5d605bfb3fe0
ORCID for Ali Tavassoli: ORCID iD orcid.org/0000-0002-7420-5063

Catalogue record

Date deposited: 11 Nov 2014 10:33
Last modified: 15 Mar 2024 03:26

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Contributors

Author: Katherine Lennard
Author: Ali Tavassoli ORCID iD

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