Improved health-related quality of life outcomes associated with SHH subgroup medulloblastoma in SIOP-UKCCSG PNET3 trial survivors
Improved health-related quality of life outcomes associated with SHH subgroup medulloblastoma in SIOP-UKCCSG PNET3 trial survivors
[Preview] Reduced health-related quality of life (HrQoL), including impaired cognitive, social, physical, behavioural and emotional functioning, is common in children treated for medulloblastoma and has been associated with clinical factors such as surgical resection and treatment modality]. recent biological advances have allowed the distinction of medulloblastomas into four consensus molecular subgroups—WNT, sHH, Group 3 and Group 4—which display distinct molecular, clinical, and pathological disease characteristics. Together, these observations raise the hypothesis that HrQoL in medulloblastoma survivors may be related to their underlying tumour biology.
151-153
Bull, Kim S.
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Kennedy, Colin R.
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Bailey, Simon
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Ellison, David W.
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Clifford, Steven C.
282d1caf-b6df-4c68-a515-3e2838e7f325
July 2014
Bull, Kim S.
751f8b25-29ba-4d4f-96e2-6c339a83a47f
Kennedy, Colin R.
7c3aff62-0a86-4b44-b7d7-4bc01f23ec93
Bailey, Simon
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Ellison, David W.
1a328751-8a19-4994-9e81-c21183ad1a0f
Clifford, Steven C.
282d1caf-b6df-4c68-a515-3e2838e7f325
Bull, Kim S., Kennedy, Colin R., Bailey, Simon, Ellison, David W. and Clifford, Steven C.
(2014)
Improved health-related quality of life outcomes associated with SHH subgroup medulloblastoma in SIOP-UKCCSG PNET3 trial survivors.
Acta Neuropathologica, 128 (1), .
(doi:10.1007/s00401-014-1300-4).
Abstract
[Preview] Reduced health-related quality of life (HrQoL), including impaired cognitive, social, physical, behavioural and emotional functioning, is common in children treated for medulloblastoma and has been associated with clinical factors such as surgical resection and treatment modality]. recent biological advances have allowed the distinction of medulloblastomas into four consensus molecular subgroups—WNT, sHH, Group 3 and Group 4—which display distinct molecular, clinical, and pathological disease characteristics. Together, these observations raise the hypothesis that HrQoL in medulloblastoma survivors may be related to their underlying tumour biology.
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Accepted/In Press date: 22 May 2014
e-pub ahead of print date: 31 May 2014
Published date: July 2014
Organisations:
Clinical & Experimental Sciences
Identifiers
Local EPrints ID: 372170
URI: http://eprints.soton.ac.uk/id/eprint/372170
ISSN: 0001-6322
PURE UUID: 68963efd-757e-4da9-81c1-3e1b2ec1574f
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Date deposited: 02 Dec 2014 17:57
Last modified: 15 Mar 2024 03:01
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Author:
Simon Bailey
Author:
David W. Ellison
Author:
Steven C. Clifford
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