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Tissue engineered bone using select growth factors: a comprehensive review of animal studies and clinical translation studies in man

Tissue engineered bone using select growth factors: a comprehensive review of animal studies and clinical translation studies in man
Tissue engineered bone using select growth factors: a comprehensive review of animal studies and clinical translation studies in man
There is a growing socio-economic need for effective strategies to repair damaged bone resulting from disease, trauma and surgical intervention. Bone tissue engineering has received substantial investment over the last few decades as a result. A multitude of studies have sought to examine the efficacy of multiple growth factors, delivery systems and biomaterials within in vivo animal models for the repair of critical-sized bone defects. Defect repair requires recapitulation of in vivo signalling cascades, including osteogenesis, chondrogenesis and angiogenesis, in an orchestrated spatiotemporal manner. Strategies to drive parallel, synergistic and consecutive signalling of factors including BMP-2, BMP-7/OP-1, FGF, PDGF, PTH, PTHrP, TGF-?3, VEGF and Wnts have demonstrated improved bone healing within animal models. Enhanced bone repair has also been demonstrated in the clinic following European Medicines Agency and Food and Drug Administration approval of BMP-2, BMP-7/OP-1, PDGF, PTH and PTHrP. The current review assesses the in vivo and clinical data surrounding the application of growth factors for bone regeneration. This review has examined data published between 1965 and 2013. All bone tissue engineering studies investigating in vivo response of the growth factors listed above, or combinations thereof, utilising animal models or human trials were included. All studies were compiled from PubMed-NCBI using search terms including ‘growth factor name’, ‘in vivo’, ‘model/animal’, ‘human’, and ‘bone tissue engineering’. Focus is drawn to the in vivo success of osteoinductive growth factors incorporated within material implants both in animals and humans, and identifies the unmet challenges within the skeletal regenerative area.
animal model, bone tissue engineering, BMP-2, BMP-7, clinical translation, FGF, human studies, in vivo, OP-1, PDGF, PTH, PTHrP, TGF-?3, VEGF, Wnt proteins
166-208
Gothard, D.
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Smith, E.L.
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Kanczler, J.M.
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Rashidi, H.
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Qutachi, O.
730ae651-dd27-4456-a53d-a3d189cdc474
Henstock, J.
171ae00a-62a3-4655-866a-db7a9de6af62
Rotherham, M.
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El Haj, A.
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Shakesheff, K.M.
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Oreffo, R.O.C.
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Gothard, D.
7ff8059e-6541-4f0f-9cdd-4f6edf0f6338
Smith, E.L.
d302ca02-1a83-43cc-ad13-b6ffd8c6aad8
Kanczler, J.M.
eb8db9ff-a038-475f-9030-48eef2b0559c
Rashidi, H.
fc8083c4-7a3d-4672-9d08-48c3ad58df27
Qutachi, O.
730ae651-dd27-4456-a53d-a3d189cdc474
Henstock, J.
171ae00a-62a3-4655-866a-db7a9de6af62
Rotherham, M.
971de3bf-0167-4c28-adcc-1626c727f38d
El Haj, A.
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Shakesheff, K.M.
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Oreffo, R.O.C.
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Gothard, D., Smith, E.L., Kanczler, J.M., Rashidi, H., Qutachi, O., Henstock, J., Rotherham, M., El Haj, A., Shakesheff, K.M. and Oreffo, R.O.C. (2014) Tissue engineered bone using select growth factors: a comprehensive review of animal studies and clinical translation studies in man. European Cells & Materials, 28, 166-208. (PMID:25284140)

Record type: Article

Abstract

There is a growing socio-economic need for effective strategies to repair damaged bone resulting from disease, trauma and surgical intervention. Bone tissue engineering has received substantial investment over the last few decades as a result. A multitude of studies have sought to examine the efficacy of multiple growth factors, delivery systems and biomaterials within in vivo animal models for the repair of critical-sized bone defects. Defect repair requires recapitulation of in vivo signalling cascades, including osteogenesis, chondrogenesis and angiogenesis, in an orchestrated spatiotemporal manner. Strategies to drive parallel, synergistic and consecutive signalling of factors including BMP-2, BMP-7/OP-1, FGF, PDGF, PTH, PTHrP, TGF-?3, VEGF and Wnts have demonstrated improved bone healing within animal models. Enhanced bone repair has also been demonstrated in the clinic following European Medicines Agency and Food and Drug Administration approval of BMP-2, BMP-7/OP-1, PDGF, PTH and PTHrP. The current review assesses the in vivo and clinical data surrounding the application of growth factors for bone regeneration. This review has examined data published between 1965 and 2013. All bone tissue engineering studies investigating in vivo response of the growth factors listed above, or combinations thereof, utilising animal models or human trials were included. All studies were compiled from PubMed-NCBI using search terms including ‘growth factor name’, ‘in vivo’, ‘model/animal’, ‘human’, and ‘bone tissue engineering’. Focus is drawn to the in vivo success of osteoinductive growth factors incorporated within material implants both in animals and humans, and identifies the unmet challenges within the skeletal regenerative area.

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Published date: 6 October 2014
Keywords: animal model, bone tissue engineering, BMP-2, BMP-7, clinical translation, FGF, human studies, in vivo, OP-1, PDGF, PTH, PTHrP, TGF-?3, VEGF, Wnt proteins
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 372175
URI: http://eprints.soton.ac.uk/id/eprint/372175
PURE UUID: 97d0ace5-6a0c-4b01-a6bd-1fb0a2944914
ORCID for J.M. Kanczler: ORCID iD orcid.org/0000-0001-7249-0414
ORCID for R.O.C. Oreffo: ORCID iD orcid.org/0000-0001-5995-6726

Catalogue record

Date deposited: 27 Nov 2014 15:52
Last modified: 15 Mar 2024 03:23

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Contributors

Author: D. Gothard
Author: E.L. Smith
Author: J.M. Kanczler ORCID iD
Author: H. Rashidi
Author: O. Qutachi
Author: J. Henstock
Author: M. Rotherham
Author: A. El Haj
Author: K.M. Shakesheff
Author: R.O.C. Oreffo ORCID iD

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