A randomised controlled trial of a preconceptional dietary intervention in women undergoing IVF treatment (PREPARE trial)
A randomised controlled trial of a preconceptional dietary intervention in women undergoing IVF treatment (PREPARE trial)
BACKGROUND:
In vitro fertilisation (IVF) treatment provides an opportunity to study early developmental responses to periconceptional dietary interventions. Retrospective studies have suggested links between preconception diet and fertility, and more recently, a "Mediterranean" diet has been reported to increase pregnancy rates by up to 40%. In addition, a prospective study examining increased intake of omega-3 polyunsaturated fats demonstrated a quickened rate of embryo development after IVF. However, up to now, few prospective randomised controlled trials have investigated the impact of periconceptional dietary interventions on fertility outcomes.
METHODS AND DESIGN:
The study is a randomised controlled trial of a dietary intervention consisting of olive oil for cooking, an olive oil based spread, and a daily supplement drink enriched with Vitamin D (10 microgram daily) and marine omega-3 fatty acids (2 g daily) for 6 weeks preconception versus a control diet of sunflower seed oil for cooking, a sunflower oil based spread, and a daily supplement drink without added Vitamin D or marine omega-3 fatty acids. Couples undergoing IVF will be randomised to either the intervention or control group (55 in each arm). The primary endpoint is embryo developmental competency in vitro, measured by validated morphokinetic markers. Secondary outcomes will include the effect of the dietary intervention on the nutritional content of the intrauterine environment.
DISCUSSION:
This approach will enable rigorous examination of the impact of the dietary intervention on early embryo development, together with the influence of the peri-implantation intra-uterine nutritional environment.
Kermack, Alexandra J.
b9294c93-c736-4505-abe4-78bee493f1c2
Calder, Philip C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Houghton, Franchesca D.
53946041-127e-45a8-9edb-bf4b3c23005f
Godfrey, Keith M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Macklon, Nicholas S.
7db1f4fc-a9f6-431f-a1f2-297bb8c9fb7e
18 November 2014
Kermack, Alexandra J.
b9294c93-c736-4505-abe4-78bee493f1c2
Calder, Philip C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Houghton, Franchesca D.
53946041-127e-45a8-9edb-bf4b3c23005f
Godfrey, Keith M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Macklon, Nicholas S.
7db1f4fc-a9f6-431f-a1f2-297bb8c9fb7e
Kermack, Alexandra J., Calder, Philip C., Houghton, Franchesca D., Godfrey, Keith M. and Macklon, Nicholas S.
(2014)
A randomised controlled trial of a preconceptional dietary intervention in women undergoing IVF treatment (PREPARE trial).
BMC Women’s Health, 14, [130].
(doi:10.1186/1472-6874-14-130).
(PMID:25407227)
Abstract
BACKGROUND:
In vitro fertilisation (IVF) treatment provides an opportunity to study early developmental responses to periconceptional dietary interventions. Retrospective studies have suggested links between preconception diet and fertility, and more recently, a "Mediterranean" diet has been reported to increase pregnancy rates by up to 40%. In addition, a prospective study examining increased intake of omega-3 polyunsaturated fats demonstrated a quickened rate of embryo development after IVF. However, up to now, few prospective randomised controlled trials have investigated the impact of periconceptional dietary interventions on fertility outcomes.
METHODS AND DESIGN:
The study is a randomised controlled trial of a dietary intervention consisting of olive oil for cooking, an olive oil based spread, and a daily supplement drink enriched with Vitamin D (10 microgram daily) and marine omega-3 fatty acids (2 g daily) for 6 weeks preconception versus a control diet of sunflower seed oil for cooking, a sunflower oil based spread, and a daily supplement drink without added Vitamin D or marine omega-3 fatty acids. Couples undergoing IVF will be randomised to either the intervention or control group (55 in each arm). The primary endpoint is embryo developmental competency in vitro, measured by validated morphokinetic markers. Secondary outcomes will include the effect of the dietary intervention on the nutritional content of the intrauterine environment.
DISCUSSION:
This approach will enable rigorous examination of the impact of the dietary intervention on early embryo development, together with the influence of the peri-implantation intra-uterine nutritional environment.
Text
1472-6874-14-130
- Version of Record
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Accepted/In Press date: 7 October 2014
e-pub ahead of print date: 18 November 2014
Published date: 18 November 2014
Organisations:
Human Development & Health
Identifiers
Local EPrints ID: 372237
URI: http://eprints.soton.ac.uk/id/eprint/372237
PURE UUID: 2ae45ebc-b628-484e-a687-e86ec79a25fe
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Date deposited: 03 Dec 2014 10:58
Last modified: 15 Mar 2024 04:04
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Author:
Nicholas S. Macklon
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