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Preparation and characterization of bioadhesive microparticles comprised of low degree of quaternization trimethylated chitosan for nasal administration: effect of concentration and molecular weight

Preparation and characterization of bioadhesive microparticles comprised of low degree of quaternization trimethylated chitosan for nasal administration: effect of concentration and molecular weight
Preparation and characterization of bioadhesive microparticles comprised of low degree of quaternization trimethylated chitosan for nasal administration: effect of concentration and molecular weight
Toward the development of microparticulate carriers for nasal administration, N-trimethylchitosan chloride (TMC) of low molecular weight (LMW) and high molecular weight (HMW) and low degree of quaternization (16% and 27%, respectively) was co-formulated into microparticles comprising of dipalmatoylphosphatidylcholine (DPPC) and poly(lactic-co-glycolic) acid (PLGA) via the spray-drying technique. The chitosan derivatives were characterized by means of nuclear magnetic resonance (NMR), differential scanning calorimetry (DSC), and Fourier transfrom infrared (FTIR) spectroscopy. The size and morphology of the produced microparticles were assessed by scanning electron microscopy (SEM), whereas their mucoadhesive properties were investigated by means of atomic force microscopy–force spectroscopy (AFM-FS). The results showed that microparticles exhibit mucoadhesion when TMC is present on their surface above a threshold of TMC (>0.3% w/w).
0743-7463
12337-12344
Karavasili, Christina
f174d197-8ba7-4765-adc8-99fa2f1c86fa
Katsamenis, Orestis
8553e7c3-d860-4b7a-a883-abf6c0c4b438
Bouropoulos, Nikolaos
fadadea1-2aa2-4cd9-a7e5-33ba790cd45f
Nazar, Hamde
f43edb87-9a8e-4019-9998-d13820eb281a
Thurner, Philipp J
ab711ddd-784e-48de-aaad-f56aec40f84f
van der Merwe, Susanna M
d4864e20-f9f4-4be0-a06c-2db971432c96
Fatouros, Dimitrios G
c7a4f13c-3e06-4143-ae1b-8a1c0eb186cc
Karavasili, Christina
f174d197-8ba7-4765-adc8-99fa2f1c86fa
Katsamenis, Orestis
8553e7c3-d860-4b7a-a883-abf6c0c4b438
Bouropoulos, Nikolaos
fadadea1-2aa2-4cd9-a7e5-33ba790cd45f
Nazar, Hamde
f43edb87-9a8e-4019-9998-d13820eb281a
Thurner, Philipp J
ab711ddd-784e-48de-aaad-f56aec40f84f
van der Merwe, Susanna M
d4864e20-f9f4-4be0-a06c-2db971432c96
Fatouros, Dimitrios G
c7a4f13c-3e06-4143-ae1b-8a1c0eb186cc

Karavasili, Christina, Katsamenis, Orestis, Bouropoulos, Nikolaos, Nazar, Hamde, Thurner, Philipp J, van der Merwe, Susanna M and Fatouros, Dimitrios G (2014) Preparation and characterization of bioadhesive microparticles comprised of low degree of quaternization trimethylated chitosan for nasal administration: effect of concentration and molecular weight. Langmuir, 30 (41), 12337-12344. (doi:10.1021/la5030636).

Record type: Article

Abstract

Toward the development of microparticulate carriers for nasal administration, N-trimethylchitosan chloride (TMC) of low molecular weight (LMW) and high molecular weight (HMW) and low degree of quaternization (16% and 27%, respectively) was co-formulated into microparticles comprising of dipalmatoylphosphatidylcholine (DPPC) and poly(lactic-co-glycolic) acid (PLGA) via the spray-drying technique. The chitosan derivatives were characterized by means of nuclear magnetic resonance (NMR), differential scanning calorimetry (DSC), and Fourier transfrom infrared (FTIR) spectroscopy. The size and morphology of the produced microparticles were assessed by scanning electron microscopy (SEM), whereas their mucoadhesive properties were investigated by means of atomic force microscopy–force spectroscopy (AFM-FS). The results showed that microparticles exhibit mucoadhesion when TMC is present on their surface above a threshold of TMC (>0.3% w/w).

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More information

e-pub ahead of print date: 23 September 2014
Published date: 21 October 2014
Organisations: Faculty of Engineering and the Environment

Identifiers

Local EPrints ID: 372320
URI: http://eprints.soton.ac.uk/id/eprint/372320
ISSN: 0743-7463
PURE UUID: 8ca7e2c0-538a-4de3-a560-0ee7c78577ad
ORCID for Orestis Katsamenis: ORCID iD orcid.org/0000-0003-4367-4147
ORCID for Philipp J Thurner: ORCID iD orcid.org/0000-0001-7588-9041

Catalogue record

Date deposited: 21 Jan 2015 16:53
Last modified: 18 Feb 2021 17:16

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