Karavasili, Christina, Katsamenis, Orestis, Bouropoulos, Nikolaos, Nazar, Hamde, Thurner, Philipp J, van der Merwe, Susanna M and Fatouros, Dimitrios G (2014) Preparation and characterization of bioadhesive microparticles comprised of low degree of quaternization trimethylated chitosan for nasal administration: effect of concentration and molecular weight. Langmuir, 30 (41), 12337-12344. (doi:10.1021/la5030636).
Abstract
Toward the development of microparticulate carriers for nasal administration, N-trimethylchitosan chloride (TMC) of low molecular weight (LMW) and high molecular weight (HMW) and low degree of quaternization (16% and 27%, respectively) was co-formulated into microparticles comprising of dipalmatoylphosphatidylcholine (DPPC) and poly(lactic-co-glycolic) acid (PLGA) via the spray-drying technique. The chitosan derivatives were characterized by means of nuclear magnetic resonance (NMR), differential scanning calorimetry (DSC), and Fourier transfrom infrared (FTIR) spectroscopy. The size and morphology of the produced microparticles were assessed by scanning electron microscopy (SEM), whereas their mucoadhesive properties were investigated by means of atomic force microscopy–force spectroscopy (AFM-FS). The results showed that microparticles exhibit mucoadhesion when TMC is present on their surface above a threshold of TMC (>0.3% w/w).
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- Faculties (pre 2018 reorg) > Faculty of Engineering and the Environment (pre 2018 reorg)
- Faculties (pre 2018 reorg) > Faculty of Engineering and the Environment (pre 2018 reorg) > Mechanical Engineering (pre 2018 reorg) > Engineering Mats & Surface Engineerg Gp (pre 2018 reorg)
Current Faculties > Faculty of Engineering and Physical Sciences > School of Engineering > Mechanical Engineering > Mechanical Engineering (pre 2018 reorg) > Engineering Mats & Surface Engineerg Gp (pre 2018 reorg)
Mechanical Engineering > Mechanical Engineering (pre 2018 reorg) > Engineering Mats & Surface Engineerg Gp (pre 2018 reorg)
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