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Methods and compositions for regulating biofilm development using Nitric Oxide

Methods and compositions for regulating biofilm development using Nitric Oxide
Methods and compositions for regulating biofilm development using Nitric Oxide
The present invention relates to methods for promoting dispersal of, or preventing formation of microbial biofilms, comprising: exposing a biofilm to an effective amount of nitric oxide or at least one nitric oxide generating or releasing agent; treating a surface or medium susceptible to biofilm formation with an effective amount of nitric oxide or at least one nitric oxide generating or releasing agent; incorporating an effective amount of nitric oxide or at least one nitric oxide generating or releasing agent in a surface or medium susceptible to biofilm formation; or inducing the accumulation of one or more reactive oxygen or nitrogen species within microorganisms within said biofilm or capable of forming a biofilm. The invention also relates to methods for maintaining or enhancing or maintaining and enhancing the functioning of a biofilm, comprising exposing a biofilm to at least one nitric oxide scavenger, at least one antioxidant or at least one nitric oxide scavenger and at least one antioxidant. The invention also relates to compositions for promoting dispersal of, or preventing formation of microbial biofilms, or for maintaining or enhancing or maintaining and enhancing the functioning of microbial biofilms.
US Patent 8,425,945
Barraud, N.
04b83401-f5b4-4e8b-8f7d-03f7b3a693f5
Webb, Jeremy S.
ec0a5c4e-86cc-4ae9-b390-7298f5d65f8d
Rice, S.
df8be5fd-d343-4379-9487-318581b6630b

Barraud, N., Webb, Jeremy S. and Rice, S. (Inventors) (2013) Methods and compositions for regulating biofilm development using Nitric Oxide. US Patent 8,425,945.

Record type: Patent

Abstract

The present invention relates to methods for promoting dispersal of, or preventing formation of microbial biofilms, comprising: exposing a biofilm to an effective amount of nitric oxide or at least one nitric oxide generating or releasing agent; treating a surface or medium susceptible to biofilm formation with an effective amount of nitric oxide or at least one nitric oxide generating or releasing agent; incorporating an effective amount of nitric oxide or at least one nitric oxide generating or releasing agent in a surface or medium susceptible to biofilm formation; or inducing the accumulation of one or more reactive oxygen or nitrogen species within microorganisms within said biofilm or capable of forming a biofilm. The invention also relates to methods for maintaining or enhancing or maintaining and enhancing the functioning of a biofilm, comprising exposing a biofilm to at least one nitric oxide scavenger, at least one antioxidant or at least one nitric oxide scavenger and at least one antioxidant. The invention also relates to compositions for promoting dispersal of, or preventing formation of microbial biofilms, or for maintaining or enhancing or maintaining and enhancing the functioning of microbial biofilms.

Full text not available from this repository.

More information

Published date: 23 April 2013
Additional Information: US8425945 (B2)
Organisations: Centre for Biological Sciences

Identifiers

Local EPrints ID: 372538
URI: https://eprints.soton.ac.uk/id/eprint/372538
PURE UUID: 18ee0ccf-3b70-4255-b8da-654850ac07b3
ORCID for Jeremy S. Webb: ORCID iD orcid.org/0000-0003-2068-8589

Catalogue record

Date deposited: 08 Dec 2014 14:05
Last modified: 06 Jun 2018 12:39

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