The actions of Caenorhabditis elegans neuropeptide-like peptides (Nlps) on body wall muscle of Ascaris suum and pharyngeal muscle of C. elegans

Walker, R.J., Holden-Dye, Lindy and Papaioannou, Sylvana (2008) The actions of Caenorhabditis elegans neuropeptide-like peptides (Nlps) on body wall muscle of Ascaris suum and pharyngeal muscle of C. elegans. Acta Biologica Hungarica, 59, supplement 2, 189-197. (doi:10.1556/ABiol.59.2008.Suppl.28). (PMID:18652392)

Abstract

The actions of six Neuropeptide-like Peptides (NLPs) were investigated on Ascaris suum dorsal body wall muscle and Caenorhabditis elegans pharyngeal muscle. The NLPs tested on A. suum muscle, viz, NLP-1A, NLP-2A and B, had no direct effect on the muscle but all reversibly reduced acetylcholine (ACh)-induced contractions of the muscle, NLP-2A being the most potent, with an IC 50 value of 78 ?M. NLP-2A also reversibly reduced ACh-induced depolarizations of A. suum muscle resting membrane potential. NLP-1A, NLP-2A, NLP-3C and NLP-10A all increased pharyngeal pumping in C. elegans , NLP-8A weakly inhibited pumping while NLP-2B was inactive. NLP-10A induced a concentration-dependent increase in pumping activity with a threshold of 10–100 nM. Since genes encoding NLPs ( nlp genes) are expressed in C. elegans pharyngeal neurons it is likely these peptides play a role in feeding behaviour.

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Contributors

Author: R.J. Walker

Author: Lindy Holden-Dye

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