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SLO, SLO, quick, quick, slow: calcium-activated potassium channels as regulators of Caenorhabditis elegans behaviour and targets for anthelmintics

SLO, SLO, quick, quick, slow: calcium-activated potassium channels as regulators of Caenorhabditis elegans behaviour and targets for anthelmintics
SLO, SLO, quick, quick, slow: calcium-activated potassium channels as regulators of Caenorhabditis elegans behaviour and targets for anthelmintics
Large-conductance calcium and voltage-activated potassium channels, termed SLO-1 (or BK), are pivotal players in the regulation of cell excitability across the animal phyla. Furthermore, emerging evidence indicates that these channels are key mediators of a number of neuroactive drugs, including the most recent new anthelmintic, the cyclo-octadepsipeptide emodepside. Detailed reviews of the structure, function and pharmacology of BK channels have recently been provided (Salkoff et al. in Nat Rev Neurosci 7:921–931, 2006; Ghatta et al. in Pharmacol Ther 110:103–116, 2006) and therefore these aspects will only briefly be covered here. The purpose of this review is to discuss how SLO-1 channels might function as regulators of neural transmission and network activity. In particular, we focus on the role of SLO-1 in the regulation of Caenorhabditis elegans behaviour and highlight the role of this channel as an effector for pleiotropic actions of neuroactive drugs, including emodepside. On the premise that C. elegans is a ‘model nematode’ with respect to many aspects of neural function, the intention is that this might inform a broader understanding of the role of these channels in the nematodes and their potential as novel anthelmintic targets.
bk channels, anthelmintics, c. elegans, slo-1, nematode
1354-2516
199-208
Holden-Dye, Lindy
8032bf60-5db6-40cb-b71c-ddda9d212c8e
O’Connor, Vincent
3c336b62-f3ef-4f78-a44c-ddc7b47bac3f
Hopper, Neil A.
d2aed184-733b-47f6-8d74-fa1633ae6cf0
Walker, Robert J.
9368ac2d-f1e9-4bd9-a4b4-4a161c4aa140
Harder, Achim
6bcbaba4-2209-45eb-a29f-5f1ac4476fa2
Bull, Kathryn
fd07202e-8fa2-419f-80ec-ba8e2a4db8b1
Guest, Marcus
62c17f1d-014a-4e56-8a39-a9987c3abbb2
Holden-Dye, Lindy
8032bf60-5db6-40cb-b71c-ddda9d212c8e
O’Connor, Vincent
3c336b62-f3ef-4f78-a44c-ddc7b47bac3f
Hopper, Neil A.
d2aed184-733b-47f6-8d74-fa1633ae6cf0
Walker, Robert J.
9368ac2d-f1e9-4bd9-a4b4-4a161c4aa140
Harder, Achim
6bcbaba4-2209-45eb-a29f-5f1ac4476fa2
Bull, Kathryn
fd07202e-8fa2-419f-80ec-ba8e2a4db8b1
Guest, Marcus
62c17f1d-014a-4e56-8a39-a9987c3abbb2

Holden-Dye, Lindy, O’Connor, Vincent, Hopper, Neil A., Walker, Robert J., Harder, Achim, Bull, Kathryn and Guest, Marcus (2007) SLO, SLO, quick, quick, slow: calcium-activated potassium channels as regulators of Caenorhabditis elegans behaviour and targets for anthelmintics. Invertebrate Neuroscience, 7 (4), 199-208. (doi:10.1007/s10158-007-0057-z). (PMID:17962986)

Record type: Article

Abstract

Large-conductance calcium and voltage-activated potassium channels, termed SLO-1 (or BK), are pivotal players in the regulation of cell excitability across the animal phyla. Furthermore, emerging evidence indicates that these channels are key mediators of a number of neuroactive drugs, including the most recent new anthelmintic, the cyclo-octadepsipeptide emodepside. Detailed reviews of the structure, function and pharmacology of BK channels have recently been provided (Salkoff et al. in Nat Rev Neurosci 7:921–931, 2006; Ghatta et al. in Pharmacol Ther 110:103–116, 2006) and therefore these aspects will only briefly be covered here. The purpose of this review is to discuss how SLO-1 channels might function as regulators of neural transmission and network activity. In particular, we focus on the role of SLO-1 in the regulation of Caenorhabditis elegans behaviour and highlight the role of this channel as an effector for pleiotropic actions of neuroactive drugs, including emodepside. On the premise that C. elegans is a ‘model nematode’ with respect to many aspects of neural function, the intention is that this might inform a broader understanding of the role of these channels in the nematodes and their potential as novel anthelmintic targets.

Full text not available from this repository.

More information

e-pub ahead of print date: October 2007
Published date: December 2007
Keywords: bk channels, anthelmintics, c. elegans, slo-1, nematode
Organisations: Centre for Biological Sciences

Identifiers

Local EPrints ID: 372588
URI: http://eprints.soton.ac.uk/id/eprint/372588
ISSN: 1354-2516
PURE UUID: de3367f6-effe-4016-8239-d72bce434b30
ORCID for Lindy Holden-Dye: ORCID iD orcid.org/0000-0002-9704-1217
ORCID for Robert J. Walker: ORCID iD orcid.org/0000-0002-9031-7671

Catalogue record

Date deposited: 09 Dec 2014 13:19
Last modified: 26 Nov 2019 02:08

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