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The range and biological activity of FMRFamide-related peptides and classical neurotransmitters in nematodes

The range and biological activity of FMRFamide-related peptides and classical neurotransmitters in nematodes
The range and biological activity of FMRFamide-related peptides and classical neurotransmitters in nematodes
Nematodes include both major parasites of humans, livestock and plants in addition to free-living species such as Caenorhabditis elegans. The nematode nervous system (especially in C. elegans) is exceptionally well defined in terms of the number, location and projection of the small number of neurons in the nervous system and their integration into circuits involved in regulatory behaviours vital to their survival. This review will summarize what is known about the biological activity of neurotransmitters in nematodes: the biosynthetic pathways and genes involved, their receptors, inactivation mechanisms and secondary messenger signalling systems. It will cover the “classical” transmitters, such as acetylcholine (ACh), GABA, glutamate, serotonin, dopamine, octopamine, noradrenaline and nitric oxide. The localization of peptides throughout the nematode nervous system is summarized, in addition to the isolation of nematode neuropeptides by both traditional biochemical techniques and more modern genetic means. The major contribution of the completion of the C. elegans genomesequencing program is highlighted throughout. Efforts to unravel neurotransmitter action in various physiological action such as locomotion, feeding and reproduction are detailed as well as the various inactivation mechanisms for the current complement of nematode transmitter.
0065-308X
109-180
Brownlee, David
f7f0d016-62f0-4202-9252-91314db2183a
Holden-Dye, Lindy
8032bf60-5db6-40cb-b71c-ddda9d212c8e
Walker, Robert
9368ac2d-f1e9-4bd9-a4b4-4a161c4aa140
Brownlee, David
f7f0d016-62f0-4202-9252-91314db2183a
Holden-Dye, Lindy
8032bf60-5db6-40cb-b71c-ddda9d212c8e
Walker, Robert
9368ac2d-f1e9-4bd9-a4b4-4a161c4aa140

Brownlee, David, Holden-Dye, Lindy and Walker, Robert (2000) The range and biological activity of FMRFamide-related peptides and classical neurotransmitters in nematodes. Advances in Parasitology, 45, 109-180. (doi:10.1016/S0065-308X(00)45004-9).

Record type: Article

Abstract

Nematodes include both major parasites of humans, livestock and plants in addition to free-living species such as Caenorhabditis elegans. The nematode nervous system (especially in C. elegans) is exceptionally well defined in terms of the number, location and projection of the small number of neurons in the nervous system and their integration into circuits involved in regulatory behaviours vital to their survival. This review will summarize what is known about the biological activity of neurotransmitters in nematodes: the biosynthetic pathways and genes involved, their receptors, inactivation mechanisms and secondary messenger signalling systems. It will cover the “classical” transmitters, such as acetylcholine (ACh), GABA, glutamate, serotonin, dopamine, octopamine, noradrenaline and nitric oxide. The localization of peptides throughout the nematode nervous system is summarized, in addition to the isolation of nematode neuropeptides by both traditional biochemical techniques and more modern genetic means. The major contribution of the completion of the C. elegans genomesequencing program is highlighted throughout. Efforts to unravel neurotransmitter action in various physiological action such as locomotion, feeding and reproduction are detailed as well as the various inactivation mechanisms for the current complement of nematode transmitter.

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Published date: 2000
Organisations: Centre for Biological Sciences

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Local EPrints ID: 372596
URI: https://eprints.soton.ac.uk/id/eprint/372596
ISSN: 0065-308X
PURE UUID: f76a3040-6ac7-494e-9027-e80a177b636f
ORCID for Robert Walker: ORCID iD orcid.org/0000-0002-9031-7671

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Date deposited: 09 Dec 2014 14:03
Last modified: 23 Jun 2018 00:20

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Author: David Brownlee
Author: Robert Walker ORCID iD

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