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Contributions of synaptic filters to models of synaptically stored memory

Contributions of synaptic filters to models of synaptically stored memory
Contributions of synaptic filters to models of synaptically stored memory
The question of how neural systems encode memories in one-shot without immediately disrupting previously stored information has puzzled theoretical neuroscientists for years and it is the central topic of this thesis. Previous attempts on this topic, have proposed that synapses probabilistically update in response to plasticity inducing stimuli to effectively delay the degradation of old memories in the face of ongoing memory storage. Indeed, experiments have shown that synapses do not immediately respond to plasticity inducing stimuli, since these must be presented many times before synaptic plasticity is expressed. Such a delay could be due to the stochastic nature of synaptic plasticity or perhaps because induction signals are integrated before overt strength changes occur.

The later approach has been previously applied to control fluctuations in neural development by low-pass filtering induction signals before plasticity is expressed. In this thesis we consider memory dynamics in a mathematical model with synapses that integrate plasticity induction signals to a threshold before expressing plasticity. We report novel recall dynamics and considerable improvements in memory lifetimes against a prominent model of synaptically stored memory. With integrating synapses the memory trace initially rises before reaching a maximum and then falls. The memory signal dissociates into separate oblivescence and reminiscence components, with reminiscence initially dominating recall. Furthermore, we find that integrating synapses possess natural timescales that can be used to consider the transition to late-phase plasticity under spaced repetition patterns known to lead to optimal storage conditions. We find that threshold crossing statistics differentiate between massed and spaced memory repetition patterns. However, isolated integrative synapses obtain an insufficient statistical sample to detect the stimulation pattern within a few memory repetitions. We extend the modelto consider the cooperation of well-known intracellular signalling pathways in detecting storage conditions by utilizing the profile of postsynaptic depolarization. We find that neuron wide signalling and local synaptic signals can be combined to detect optimal storage conditions that lead to stable forms of plasticity in a synapse specific manner.
These models can be further extended to consider heterosynaptic and neuromodulatory interactions for late-phase plasticity.
University of Southampton
Lagogiannis, Konstantinos
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Lagogiannis, Konstantinos
eb11d097-6ebd-4fe9-ae2f-c290f3d89738
Shadbolt, Nigel
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Lagogiannis, Konstantinos (2013) Contributions of synaptic filters to models of synaptically stored memory. University of Southampton, Faculty of Physical Sciences and Engineering, Doctoral Thesis, 353pp.

Record type: Thesis (Doctoral)

Abstract

The question of how neural systems encode memories in one-shot without immediately disrupting previously stored information has puzzled theoretical neuroscientists for years and it is the central topic of this thesis. Previous attempts on this topic, have proposed that synapses probabilistically update in response to plasticity inducing stimuli to effectively delay the degradation of old memories in the face of ongoing memory storage. Indeed, experiments have shown that synapses do not immediately respond to plasticity inducing stimuli, since these must be presented many times before synaptic plasticity is expressed. Such a delay could be due to the stochastic nature of synaptic plasticity or perhaps because induction signals are integrated before overt strength changes occur.

The later approach has been previously applied to control fluctuations in neural development by low-pass filtering induction signals before plasticity is expressed. In this thesis we consider memory dynamics in a mathematical model with synapses that integrate plasticity induction signals to a threshold before expressing plasticity. We report novel recall dynamics and considerable improvements in memory lifetimes against a prominent model of synaptically stored memory. With integrating synapses the memory trace initially rises before reaching a maximum and then falls. The memory signal dissociates into separate oblivescence and reminiscence components, with reminiscence initially dominating recall. Furthermore, we find that integrating synapses possess natural timescales that can be used to consider the transition to late-phase plasticity under spaced repetition patterns known to lead to optimal storage conditions. We find that threshold crossing statistics differentiate between massed and spaced memory repetition patterns. However, isolated integrative synapses obtain an insufficient statistical sample to detect the stimulation pattern within a few memory repetitions. We extend the modelto consider the cooperation of well-known intracellular signalling pathways in detecting storage conditions by utilizing the profile of postsynaptic depolarization. We find that neuron wide signalling and local synaptic signals can be combined to detect optimal storage conditions that lead to stable forms of plasticity in a synapse specific manner.
These models can be further extended to consider heterosynaptic and neuromodulatory interactions for late-phase plasticity.

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Published date: October 2013
Organisations: University of Southampton, Web & Internet Science

Identifiers

Local EPrints ID: 372747
URI: http://eprints.soton.ac.uk/id/eprint/372747
PURE UUID: 6d5eb557-bc51-49c0-b3b5-541004eb134d

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Date deposited: 19 Jan 2015 10:04
Last modified: 13 Dec 2018 12:30

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Contributors

Author: Konstantinos Lagogiannis
Thesis advisor: Nigel Shadbolt

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