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The effect of neoadjuvant chemotherapy on physical fitness and survival in patients undergoing oesophagogastric cancer surgery

Jackson, Sarah E., West, M.A., Raw, D., Marwood, S., Ambler, G., Cope, T.M., Shrotri, M., Sturgess, R.P., Calverley, P.M.A., Ottensmeier, C.H. and Grocott, M.P.W. (2014) The effect of neoadjuvant chemotherapy on physical fitness and survival in patients undergoing oesophagogastric cancer surgery European Journal of Surgical Oncology, 40, (10), pp. 1313-1320. (doi:10.1016/j.ejso.2014.03.010). (PMID:24731268).

Record type: Article

Abstract

BACKGROUND: Neoadjuvant chemotherapy (NAC) followed by surgery for resectable oesophageal or gastric cancer improves outcome when compared with surgery alone. However NAC has adverse effects. We assess here whether NAC adversely affects physical fitness and whether such an effect is associated with impaired survival following surgery.

METHODS: We prospectively studied 116 patients with oesophageal or gastric cancer to assess the effect of NAC on physical fitness, of whom 89 underwent cardiopulmonary exercise testing (CPET) before NAC and proceeded to surgery. 39 patients were tested after all cycles of NAC but prior to surgery. Physical fitness was assessed by measuring oxygen uptake (VO? in ml kg(-1) min(-1)) at the estimated lactate threshold (?L) and at peak exercise (VO? peak in ml kg(-1) min(-1)).

RESULTS: VO? at ?L and at peak were significantly lower after NAC compared to pre-NAC values: VO? at ?L 14.5 ± 3.8 (baseline) vs. 12.3 ± 3.0 (post-NAC) ml kg(-1) min(-1); p ? 0.001; VO? peak 20.8 ± 6.0 vs. 18.3 ± 5.1 ml kg(-1) min(-1); p ? 0.001; absolute VO? (ml min(-1)) at ?L and peak were also lower post-NAC; p ? 0.001. Decreased baseline VO? at ?L and peak were associated with increased one year mortality in patients who completed a full course of NAC and had surgery; p = 0.014.

CONCLUSION: NAC before cancer surgery significantly reduced physical fitness in the overall cohort. Lower baseline fitness was associated with reduced one-year-survival in patients completing NAC and surgery, but not in patients who did not complete NAC. It is possible that in some patients the harms of NAC may outweigh the benefits.

Trials Registry Number: NCT01335555.

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More information

e-pub ahead of print date: 27 March 2014
Published date: October 2014
Keywords: neoadjuvant chemotherapy, cardiopulmonary exercise testing, cancer surgery, survival, oesphagogastric, physical fitness
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 372838
URI: http://eprints.soton.ac.uk/id/eprint/372838
ISSN: 0748-7983
PURE UUID: d379bdbe-28fe-411e-87f2-8da4c0761040

Catalogue record

Date deposited: 23 Dec 2014 11:29
Last modified: 17 Jul 2017 21:38

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Contributors

Author: Sarah E. Jackson
Author: M.A. West
Author: D. Raw
Author: S. Marwood
Author: G. Ambler
Author: T.M. Cope
Author: M. Shrotri
Author: R.P. Sturgess
Author: P.M.A. Calverley
Author: M.P.W. Grocott

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