Gilbert-Kawai, Edward T., Mitchell, Kay, Martin, Daniel, Carlisle, John and Grocott, Michael P.W.
Permissive hypoxaemia versus normoxaemia for mechanically ventilated critically ill patients
Cochrane Database of Systematic Reviews, 5, . (doi:10.1002/14651858.CD009931.pub2). (PMID:24801519).
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This comprehensive review failed to identify any relevant studies evaluating permissive hypoxaemia versus normoxaemia in mechanically ventilated critically ill participants. Therefore we are unable to support or refute the hypothesis that this treatment strategy is of benefit to patients.Given the substantial amount of provocative evidence derived from related clinical contexts (resuscitation, myocardial infarction, stroke), we believe that this review highlights an important unanswered question within critical care. In the presence of two competing harms (hypoxia and hyperoxia), it will be important to carefully evaluate the safety and feasibility of permissive hypoxaemia before proceeding to efficacy and effectiveness trials.
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