Permissive hypoxaemia versus normoxaemia for mechanically ventilated critically ill patients


Gilbert-Kawai, Edward T., Mitchell, Kay, Martin, Daniel, Carlisle, John and Grocott, Michael P.W. (2014) Permissive hypoxaemia versus normoxaemia for mechanically ventilated critically ill patients Cochrane Database of Systematic Reviews, 5, CD009931. (doi:10.1002/14651858.CD009931.pub2). (PMID:24801519).

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Description/Abstract

This comprehensive review failed to identify any relevant studies evaluating permissive hypoxaemia versus normoxaemia in mechanically ventilated critically ill participants. Therefore we are unable to support or refute the hypothesis that this treatment strategy is of benefit to patients.Given the substantial amount of provocative evidence derived from related clinical contexts (resuscitation, myocardial infarction, stroke), we believe that this review highlights an important unanswered question within critical care. In the presence of two competing harms (hypoxia and hyperoxia), it will be important to carefully evaluate the safety and feasibility of permissive hypoxaemia before proceeding to efficacy and effectiveness trials.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1002/14651858.CD009931.pub2
ISSNs: 1469-493X (print)
Subjects: R Medicine > R Medicine (General)
Organisations: Clinical & Experimental Sciences
ePrint ID: 372841
Date :
Date Event
7 May 2014e-pub ahead of print
Date Deposited: 22 Dec 2014 13:20
Last Modified: 19 Feb 2017 16:33
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/372841

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