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Use of hemodynamic algorithm after gastrointestinal surgery - reply

Use of hemodynamic algorithm after gastrointestinal surgery - reply
Use of hemodynamic algorithm after gastrointestinal surgery - reply
In Reply Drs Saugel and Reuter challenge the description of the OPTIMISE trial as a pragmatic trial. As applied to clinical trials, the term pragmatic has a particular meaning. Pragmatic trials are designed to evaluate the clinical effectiveness of a treatment in the context of routine clinical practice.1 This distinguishes them from explanatory trials, which are designed to evaluate the efficacy of a treatment under ideal conditions.
0098-7484
1471
Pearse, Rupert M.
50f634bc-77c8-4f69-8650-e2b0a29ceaed
MacDonald, Neil
1edcce7f-0096-4f87-a4ef-23b021daa71d
Grocott, Michael P.W.
1e87b741-513e-4a22-be13-0f7bb344e8c2
Pearse, Rupert M.
50f634bc-77c8-4f69-8650-e2b0a29ceaed
MacDonald, Neil
1edcce7f-0096-4f87-a4ef-23b021daa71d
Grocott, Michael P.W.
1e87b741-513e-4a22-be13-0f7bb344e8c2

Pearse, Rupert M., MacDonald, Neil and Grocott, Michael P.W. (2014) Use of hemodynamic algorithm after gastrointestinal surgery - reply. JAMA, 312 (14), 1471. (doi:10.1001/jama.2014.10366). (PMID:25291591)

Record type: Article

Abstract

In Reply Drs Saugel and Reuter challenge the description of the OPTIMISE trial as a pragmatic trial. As applied to clinical trials, the term pragmatic has a particular meaning. Pragmatic trials are designed to evaluate the clinical effectiveness of a treatment in the context of routine clinical practice.1 This distinguishes them from explanatory trials, which are designed to evaluate the efficacy of a treatment under ideal conditions.

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Published date: 8 October 2014
Organisations: Clinical & Experimental Sciences

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Local EPrints ID: 372848
URI: http://eprints.soton.ac.uk/id/eprint/372848
DOI: doi:10.1001/jama.2014.10366
ISSN: 0098-7484
PURE UUID: d0d1100d-d759-4afb-9eb3-b5860d6f1f0b
ORCID for Michael P.W. Grocott: ORCID iD orcid.org/0000-0002-9484-7581

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Date deposited: 23 Dec 2014 11:51
Last modified: 15 Mar 2024 03:33

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Contributors

Author: Rupert M. Pearse
Author: Neil MacDonald
Author: Michael P.W. Grocott ORCID iD

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