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Use of hemodynamic algorithm after gastrointestinal surgery - reply

Pearse, Rupert M., MacDonald, Neil and Grocott, Michael P.W. (2014) Use of hemodynamic algorithm after gastrointestinal surgery - reply JAMA: The Journal of the American Medical Association, 312, (14), p. 1471. (PMID:25291591).

Record type: Article


In Reply Drs Saugel and Reuter challenge the description of the OPTIMISE trial as a pragmatic trial. As applied to clinical trials, the term pragmatic has a particular meaning. Pragmatic trials are designed to evaluate the clinical effectiveness of a treatment in the context of routine clinical practice.1 This distinguishes them from explanatory trials, which are designed to evaluate the efficacy of a treatment under ideal conditions.

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Published date: 8 October 2014
Organisations: Clinical & Experimental Sciences


Local EPrints ID: 372848
ISSN: 0098-7484
PURE UUID: d0d1100d-d759-4afb-9eb3-b5860d6f1f0b

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Date deposited: 23 Dec 2014 11:51
Last modified: 05 Oct 2017 06:11

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Author: Rupert M. Pearse
Author: Neil MacDonald

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