Use of hemodynamic algorithm after gastrointestinal surgery - reply


Pearse, Rupert M., MacDonald, Neil and Grocott, Michael P.W. (2014) Use of hemodynamic algorithm after gastrointestinal surgery - reply JAMA The Journal of the American Medical Association, 312, (14), p. 1471. (doi:10.1001/jama.2014.10366). (PMID:25291591).

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Description/Abstract

In Reply Drs Saugel and Reuter challenge the description of the OPTIMISE trial as a pragmatic trial. As applied to clinical trials, the term pragmatic has a particular meaning. Pragmatic trials are designed to evaluate the clinical effectiveness of a treatment in the context of routine clinical practice.1 This distinguishes them from explanatory trials, which are designed to evaluate the efficacy of a treatment under ideal conditions.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1001/jama.2014.10366
ISSNs: 0098-7484 (print)
Subjects: R Medicine > RD Surgery
R Medicine > RM Therapeutics. Pharmacology
Organisations: Clinical & Experimental Sciences
ePrint ID: 372848
Date :
Date Event
8 October 2014Published
Date Deposited: 23 Dec 2014 11:51
Last Modified: 19 Feb 2017 16:34
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/372848

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