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Minimal enteral nutrition during neonatal hypothermia treatment for perinatal hypoxic-ischaemic encephalopathy is safe and feasible

Minimal enteral nutrition during neonatal hypothermia treatment for perinatal hypoxic-ischaemic encephalopathy is safe and feasible
Minimal enteral nutrition during neonatal hypothermia treatment for perinatal hypoxic-ischaemic encephalopathy is safe and feasible
Aim

The safety and efficacy of enteral feeding during hypothermia treatment following hypoxic ischaemic encephalopathy has not been studied before, resulting in variations in practice. Our study compared the benefits and safety of both early minimal and delayed enteral feeding during hypothermia treatment.

Methods

Our retrospective cohort study,from January 2009 to December 2011, compared a Swedish cohort,who received early enteral feeding during hypothermia, and a UK cohort,who received delayed enteral feeding.

Result

In Sweden (n=51), enteral feeds were initiated at a median of 23.6 hours and full oral feeding was achieved at ninedays (range 3-23). In the UK (n=34), the equivalent figures were 100 hoursand eight days (range 3-13) (p=0.01).Both groups achieved enteral feeding at a median six days. The median length of hospital stay was 13 days in Sweden and 10 days in the UK (p=0.04). More babies were fully breastfeeding or breast-fed and bottle-fed at discharge in Sweden (85%) than the UK (67%) (p=0.08). There were no significant differences between the two groups regarding adverse events.

Conclusion

Early minimal enteral feeding during hypothermia provedfeasible,with no significant complications. Delayed enteral feeding did not affect time to full enteral feeding.
hypothermia, enteral nutrition, perinatal hypoxic-ischaemic encephalopathy, breastfeeding
0803-5253
146-151
Thyagarajan, Balamurugan
35ab1c17-1caf-442b-b4cc-c2dfb5b8a7ac
Tillqvist, Emma
2d9f5be4-89be-4b3c-95b0-79ff8bbc721a
Baral, Vijay
f3a17558-034e-4e67-a1f0-69b4e58d4979
Hallberg, Boubou
afac0039-8dc9-45c5-a695-4778134abfb1
Vollmer, Brigitte
044f8b55-ba36-4fb2-8e7e-756ab77653ba
Blennow, Mats
14d9f9ca-4587-4372-b964-463355551e31
Thyagarajan, Balamurugan
35ab1c17-1caf-442b-b4cc-c2dfb5b8a7ac
Tillqvist, Emma
2d9f5be4-89be-4b3c-95b0-79ff8bbc721a
Baral, Vijay
f3a17558-034e-4e67-a1f0-69b4e58d4979
Hallberg, Boubou
afac0039-8dc9-45c5-a695-4778134abfb1
Vollmer, Brigitte
044f8b55-ba36-4fb2-8e7e-756ab77653ba
Blennow, Mats
14d9f9ca-4587-4372-b964-463355551e31

Thyagarajan, Balamurugan, Tillqvist, Emma, Baral, Vijay, Hallberg, Boubou, Vollmer, Brigitte and Blennow, Mats (2015) Minimal enteral nutrition during neonatal hypothermia treatment for perinatal hypoxic-ischaemic encephalopathy is safe and feasible. Acta Paediatrica, 104 (2), 146-151. (doi:10.1111/apa.12838). (PMID:25348803)

Record type: Article

Abstract

Aim

The safety and efficacy of enteral feeding during hypothermia treatment following hypoxic ischaemic encephalopathy has not been studied before, resulting in variations in practice. Our study compared the benefits and safety of both early minimal and delayed enteral feeding during hypothermia treatment.

Methods

Our retrospective cohort study,from January 2009 to December 2011, compared a Swedish cohort,who received early enteral feeding during hypothermia, and a UK cohort,who received delayed enteral feeding.

Result

In Sweden (n=51), enteral feeds were initiated at a median of 23.6 hours and full oral feeding was achieved at ninedays (range 3-23). In the UK (n=34), the equivalent figures were 100 hoursand eight days (range 3-13) (p=0.01).Both groups achieved enteral feeding at a median six days. The median length of hospital stay was 13 days in Sweden and 10 days in the UK (p=0.04). More babies were fully breastfeeding or breast-fed and bottle-fed at discharge in Sweden (85%) than the UK (67%) (p=0.08). There were no significant differences between the two groups regarding adverse events.

Conclusion

Early minimal enteral feeding during hypothermia provedfeasible,with no significant complications. Delayed enteral feeding did not affect time to full enteral feeding.

Full text not available from this repository.

More information

e-pub ahead of print date: 2014
Published date: February 2015
Keywords: hypothermia, enteral nutrition, perinatal hypoxic-ischaemic encephalopathy, breastfeeding
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 372878
URI: http://eprints.soton.ac.uk/id/eprint/372878
ISSN: 0803-5253
PURE UUID: 1d725c2a-b52f-47b6-ad2d-ed99179eb3b9
ORCID for Brigitte Vollmer: ORCID iD orcid.org/0000-0003-4088-5336

Catalogue record

Date deposited: 24 Dec 2014 14:25
Last modified: 18 Feb 2021 17:15

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Contributors

Author: Balamurugan Thyagarajan
Author: Emma Tillqvist
Author: Vijay Baral
Author: Boubou Hallberg
Author: Mats Blennow

University divisions

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