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On the chemical biology of the nitrite/sulfide interaction

On the chemical biology of the nitrite/sulfide interaction
On the chemical biology of the nitrite/sulfide interaction
Sulfide (H2S/HS(-)) has been demonstrated to exert an astounding breadth of biological effects, some of which resemble those of nitric oxide (NO). While the chemistry, biochemistry and potential (patho)physiology of the cross-talk between sulfide and NO has received considerable attention lately, a comparable assessment of the potential biological implications of an interaction between nitrite and sulfide is lacking. This is surprising inasmuch as nitrite is not only a known bioactive oxidation product of NO, but also efficiently converted to S-nitrosothiols in vivo; the latter have been shown to rapidly react with sulfide in vitro, leading to formation of S/N-hybrid species including thionitrite (SNO(-)) and nitrosopersulfide (SSNO(-)). Moreover, nitrite is used as a potent remedy against sulfide poisoning in the clinic. The chemistry of interaction between nitrite and sulfide or related bioactive metabolites including polysulfides and elemental sulfur has been extensively studied in the past, yet much of this information appears to have been forgotten. In this review, we focus on the potential chemical biology of the interaction between nitrite and sulfide or sulfane sulfur molecules, calling attention to the fundamental chemical properties and reactivity of either species and discuss its possible contribution to the biology, pharmacology and toxicology of both nitrite and sulfide.
hypoxia, nitrite, nitroxyl, ssno(-), sulfane sulphur, sulfide
1089-8603
14-24
Cortese-Krott, Miriam M.
7dc9b44c-847c-4196-8866-a3cc0c1dc357
Fernandez, Bernadette O.
9890aabc-1fe6-4530-a51e-31182e537131
Kelm, Malte
db2bb062-32d7-4b50-9f65-8ba89ffa5f42
Butler, Anthony R.
4e1c6bdd-2b66-44d8-9ff7-61466adf9dd3
Feelisch, Martin
8c1b9965-8614-4e85-b2c6-458a2e17eafd
Cortese-Krott, Miriam M.
7dc9b44c-847c-4196-8866-a3cc0c1dc357
Fernandez, Bernadette O.
9890aabc-1fe6-4530-a51e-31182e537131
Kelm, Malte
db2bb062-32d7-4b50-9f65-8ba89ffa5f42
Butler, Anthony R.
4e1c6bdd-2b66-44d8-9ff7-61466adf9dd3
Feelisch, Martin
8c1b9965-8614-4e85-b2c6-458a2e17eafd

Cortese-Krott, Miriam M., Fernandez, Bernadette O., Kelm, Malte, Butler, Anthony R. and Feelisch, Martin (2014) On the chemical biology of the nitrite/sulfide interaction. Nitric Oxide, 46, 14-24. (doi:10.1016/j.niox.2014.12.009). (PMID:25541073)

Record type: Article

Abstract

Sulfide (H2S/HS(-)) has been demonstrated to exert an astounding breadth of biological effects, some of which resemble those of nitric oxide (NO). While the chemistry, biochemistry and potential (patho)physiology of the cross-talk between sulfide and NO has received considerable attention lately, a comparable assessment of the potential biological implications of an interaction between nitrite and sulfide is lacking. This is surprising inasmuch as nitrite is not only a known bioactive oxidation product of NO, but also efficiently converted to S-nitrosothiols in vivo; the latter have been shown to rapidly react with sulfide in vitro, leading to formation of S/N-hybrid species including thionitrite (SNO(-)) and nitrosopersulfide (SSNO(-)). Moreover, nitrite is used as a potent remedy against sulfide poisoning in the clinic. The chemistry of interaction between nitrite and sulfide or related bioactive metabolites including polysulfides and elemental sulfur has been extensively studied in the past, yet much of this information appears to have been forgotten. In this review, we focus on the potential chemical biology of the interaction between nitrite and sulfide or sulfane sulfur molecules, calling attention to the fundamental chemical properties and reactivity of either species and discuss its possible contribution to the biology, pharmacology and toxicology of both nitrite and sulfide.

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More information

e-pub ahead of print date: 23 December 2014
Keywords: hypoxia, nitrite, nitroxyl, ssno(-), sulfane sulphur, sulfide
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 373160
URI: https://eprints.soton.ac.uk/id/eprint/373160
ISSN: 1089-8603
PURE UUID: e7c6420f-81f9-4fb9-b5f4-fd6a72ad947b
ORCID for Bernadette O. Fernandez: ORCID iD orcid.org/0000-0001-6337-0381
ORCID for Martin Feelisch: ORCID iD orcid.org/0000-0003-2320-1158

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Date deposited: 12 Jan 2015 10:23
Last modified: 25 Apr 2019 00:31

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