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Chlamydia trachomatis from Australian Aboriginal people with trachoma are polyphyletic composed of multiple distinctive lineages

Chlamydia trachomatis from Australian Aboriginal people with trachoma are polyphyletic composed of multiple distinctive lineages
Chlamydia trachomatis from Australian Aboriginal people with trachoma are polyphyletic composed of multiple distinctive lineages
Chlamydia trachomatis causes sexually transmitted infections and the blinding disease trachoma. Current data on C. trachomatis phylogeny show that there is only a single trachoma-causing clade, which is distinct from the lineages causing urogenital tract (UGT) and lymphogranuloma venerum diseases. Here we report the whole-genome sequences of ocular C. trachomatis isolates obtained from young children with clinical signs of trachoma in a trachoma endemic region of northern Australia. The isolates form two lineages that fall outside the classical trachoma lineage, instead being placed within UGT clades of the C. trachomatis phylogenetic tree. The Australian trachoma isolates appear to be recombinants with UGT C. trachomatis genome backbones, in which loci that encode immunodominant surface proteins (ompA and pmpEFGH) have been replaced by those characteristic of classical ocular isolates. This suggests that ocular tropism and association with trachoma are functionally associated with some sequence variants of ompA and pmpEFGH.
1-11
Andersson, Patiyan
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Harris, Simon R.
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Smith, Helena M.B.
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Hadfield, James
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O'Neill, Colette
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Cutcliffe, Lesley T.
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Douglas, Fiona P.
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Asche, L. Valerie
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Mathews, John D.
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Hutton, Susan I.
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Sarovich, Derek S.
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Tong, Steven Y.C.
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Clarke, Ian N.
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Thomson, Nicholas R.
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Giffard, Philip M.
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Andersson, Patiyan
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Harris, Simon R.
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Smith, Helena M.B.
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Hadfield, James
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O'Neill, Colette
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Cutcliffe, Lesley T.
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Douglas, Fiona P.
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Asche, L. Valerie
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Mathews, John D.
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Hutton, Susan I.
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Sarovich, Derek S.
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Tong, Steven Y.C.
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Clarke, Ian N.
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Thomson, Nicholas R.
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Giffard, Philip M.
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Andersson, Patiyan, Harris, Simon R., Smith, Helena M.B., Hadfield, James, O'Neill, Colette, Cutcliffe, Lesley T., Douglas, Fiona P., Asche, L. Valerie, Mathews, John D., Hutton, Susan I., Sarovich, Derek S., Tong, Steven Y.C., Clarke, Ian N., Thomson, Nicholas R. and Giffard, Philip M. (2016) Chlamydia trachomatis from Australian Aboriginal people with trachoma are polyphyletic composed of multiple distinctive lineages. Nature Communications, 7 (10688), 1-11. (doi:10.1038/ncomms10688). (PMID:26912299)

Record type: Article

Abstract

Chlamydia trachomatis causes sexually transmitted infections and the blinding disease trachoma. Current data on C. trachomatis phylogeny show that there is only a single trachoma-causing clade, which is distinct from the lineages causing urogenital tract (UGT) and lymphogranuloma venerum diseases. Here we report the whole-genome sequences of ocular C. trachomatis isolates obtained from young children with clinical signs of trachoma in a trachoma endemic region of northern Australia. The isolates form two lineages that fall outside the classical trachoma lineage, instead being placed within UGT clades of the C. trachomatis phylogenetic tree. The Australian trachoma isolates appear to be recombinants with UGT C. trachomatis genome backbones, in which loci that encode immunodominant surface proteins (ompA and pmpEFGH) have been replaced by those characteristic of classical ocular isolates. This suggests that ocular tropism and association with trachoma are functionally associated with some sequence variants of ompA and pmpEFGH.

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Accepted/In Press date: 7 January 2016
Published date: 25 February 2016
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 373162
URI: https://eprints.soton.ac.uk/id/eprint/373162
PURE UUID: 7829d152-bad9-4f93-9b06-4b2780b6a167
ORCID for Ian N. Clarke: ORCID iD orcid.org/0000-0002-4938-1620

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Date deposited: 25 May 2016 13:49
Last modified: 06 Jun 2018 13:19

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Contributors

Author: Patiyan Andersson
Author: Simon R. Harris
Author: Helena M.B. Smith
Author: James Hadfield
Author: Colette O'Neill
Author: Lesley T. Cutcliffe
Author: Fiona P. Douglas
Author: L. Valerie Asche
Author: John D. Mathews
Author: Susan I. Hutton
Author: Derek S. Sarovich
Author: Steven Y.C. Tong
Author: Ian N. Clarke ORCID iD
Author: Nicholas R. Thomson
Author: Philip M. Giffard

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