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Effects of antipsychotics on bone mineral density and prolactin levels in patients with schizophrenia: a 12-month prospective study

Effects of antipsychotics on bone mineral density and prolactin levels in patients with schizophrenia: a 12-month prospective study
Effects of antipsychotics on bone mineral density and prolactin levels in patients with schizophrenia: a 12-month prospective study
Objective: Effects of conventional and atypical antipsychotics on bone mineral density (BMD) and serum prolactin levels (PRL) were examined in patients with schizophrenia.

Methods: One hundred and sixty-three first-episode inpatients with schizophrenia were recruited, to whom one of three conventional antipsychotics (perphenazine, sulpiride, and chlorpromazine) or one of three atypical antipsychotics (clozapine, quetiapine, and aripiprazole)
was prescribed for 12 months as appropriate. BMD and PRL were tested before and after treatment. Same measures were conducted in 90 matched healthy controls.


Results Baseline BMD of postero-anterior L1–L4 range from 1.04 ± 0.17 to 1.42 ± 1.23, and there was no significant difference between the patients group and healthy control group. However, post-treatment BMD values in patients (ranging from 1.02 ± 0.15 to 1.23 ± 0.10) were significantly lower than that in healthy controls (ranging from 1.15 ± 0.12 to 1.42 ± 1.36). The BMD values after conventional antipsychotics were significantly lower than that after atypical antipsychotics. The PRL level after conventional antipsychotics (53.05 ± 30.25 ng/ml) was significantly higher than that after atypical antipsychotics (32.81 ± 17.42 ng/ml). Conditioned relevance analysis revealed significant negative correlations between the PRL level and the BMD values after conventional antipsychotics.

Conclusion The increase of PRL might be an important risk factor leading to a high prevalence of osteoporosis in patients with schizophrenia on long-term conventional antipsychotic medication.
conventional/atypical antipsychotics, bone mineral density, prolactin, schizophrenia
0885-6222
183-189
Wang, Mengxin
8b512c13-9533-4262-b06a-a2e8e2e18d9d
Hou, Ruihua
470bdcbc-93a9-4dad-aac5-26d455c34376
Jian, Jia
6424acfe-cfb7-4895-acff-5b0f803faed9
Mi, Guolin
32ae4bee-0039-4132-9dd6-8264593ff2d9
Qu, Huimin
bdf32358-d3d7-4faa-860d-36bc6a75b729
Cao, Bingyu
434ac0a7-6fa0-4d92-8841-5d8915b8877d
Tang, Maoqin
a203815b-746f-4ba8-b683-7e32e6f086f9
Wang, Mengxin
8b512c13-9533-4262-b06a-a2e8e2e18d9d
Hou, Ruihua
470bdcbc-93a9-4dad-aac5-26d455c34376
Jian, Jia
6424acfe-cfb7-4895-acff-5b0f803faed9
Mi, Guolin
32ae4bee-0039-4132-9dd6-8264593ff2d9
Qu, Huimin
bdf32358-d3d7-4faa-860d-36bc6a75b729
Cao, Bingyu
434ac0a7-6fa0-4d92-8841-5d8915b8877d
Tang, Maoqin
a203815b-746f-4ba8-b683-7e32e6f086f9

Wang, Mengxin, Hou, Ruihua, Jian, Jia, Mi, Guolin, Qu, Huimin, Cao, Bingyu and Tang, Maoqin (2014) Effects of antipsychotics on bone mineral density and prolactin levels in patients with schizophrenia: a 12-month prospective study. Human Psychopharmacology: Clinical and Experimental, 29, 183-189. (doi:10.1002/hup.2387). (PMID:24738111)

Record type: Article

Abstract

Objective: Effects of conventional and atypical antipsychotics on bone mineral density (BMD) and serum prolactin levels (PRL) were examined in patients with schizophrenia.

Methods: One hundred and sixty-three first-episode inpatients with schizophrenia were recruited, to whom one of three conventional antipsychotics (perphenazine, sulpiride, and chlorpromazine) or one of three atypical antipsychotics (clozapine, quetiapine, and aripiprazole)
was prescribed for 12 months as appropriate. BMD and PRL were tested before and after treatment. Same measures were conducted in 90 matched healthy controls.


Results Baseline BMD of postero-anterior L1–L4 range from 1.04 ± 0.17 to 1.42 ± 1.23, and there was no significant difference between the patients group and healthy control group. However, post-treatment BMD values in patients (ranging from 1.02 ± 0.15 to 1.23 ± 0.10) were significantly lower than that in healthy controls (ranging from 1.15 ± 0.12 to 1.42 ± 1.36). The BMD values after conventional antipsychotics were significantly lower than that after atypical antipsychotics. The PRL level after conventional antipsychotics (53.05 ± 30.25 ng/ml) was significantly higher than that after atypical antipsychotics (32.81 ± 17.42 ng/ml). Conditioned relevance analysis revealed significant negative correlations between the PRL level and the BMD values after conventional antipsychotics.

Conclusion The increase of PRL might be an important risk factor leading to a high prevalence of osteoporosis in patients with schizophrenia on long-term conventional antipsychotic medication.

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More information

Published date: March 2014
Keywords: conventional/atypical antipsychotics, bone mineral density, prolactin, schizophrenia
Organisations: Clinical & Experimental Sciences

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Local EPrints ID: 373255
URI: https://eprints.soton.ac.uk/id/eprint/373255
ISSN: 0885-6222
PURE UUID: bf670daf-812f-41f6-bd04-08a80f87bd15

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Date deposited: 13 Jan 2015 13:39
Last modified: 28 Oct 2019 20:50

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