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Risk factors for incidence and persistence of disability in chronic major depression and alcohol use disorders: longitudinal analyses of a population-based study

Risk factors for incidence and persistence of disability in chronic major depression and alcohol use disorders: longitudinal analyses of a population-based study
Risk factors for incidence and persistence of disability in chronic major depression and alcohol use disorders: longitudinal analyses of a population-based study
Background
Major depression and alcohol use disorders are risk factors for incidence of disability. However, it is still unclear whether a chronic course of these health conditions is also prospectively associated with incidence of disability. The aim of the present study was, first, to confirm whether chronic major depression (MD) and alcohol use disorders (AUD) are, respectively, risk factors for persistence and incidence of disability in the general population; and then to analyze the role of help-seeking behavior in the course of disability among respondents with chronic MD and chronic AUD.

Method
Data from two assessments in the National Epidemiologic Survey on Alcohol and Related Conditions were analyzed. Disability was measured by eight domains of the Short Form 12 Health Survey version 2 (SF-12). Generalized estimating equations and logistic regression models were run to estimate risk factors for persistence and incidence of disability, respectively.

Results
Analyses conducted on data from the US general population showed that chronic MD was the strongest risk factor for incidence and persistence of disability in the social functioning, emotional role and mental health domains. Chronic AUD were risk factors for incidence and persistence of disability in the vitality, social functioning, and emotional role domains. Within the group of chronic MD, physical comorbidity and help-seeking were associated with persistent disability in most of the SF-12 domains. Help-seeking behavior was also associated with incidence of problems in the mental health domain for the depression group. Regarding the AUD group, comorbidity with physical health problems was a strong risk factor for persistence of disability in all SF-12 domains. Help-seeking behavior was not related to either persistence or incidence of disability in the chronic alcohol group.

Conclusions
Chronic MD and chronic AUD are independent risk factors for persistence and incidence of disability in the US general population. People with chronic MD seek help for their problems when they experience persistent disability, whereas people with chronic AUD might not seek any help even if they are suffering from persistent disability.
major depression, alcohol use disorders, disability
1477-7525
186-[24pp]
Cabello, M.
cf2fe279-c6c7-431a-9ddf-6ff548d07458
Caballero, F.
782e983c-76b9-4ec2-8ade-c1dd7399100f
Chatterji, S.
0d10ce3d-518a-4d87-a3bc-6dcb7b365ac6
Cieza, A.
a0df25c5-ee2c-4580-82b3-d0a75591580e
Ayuso-Mateos, J.
a73369d3-3b9c-42c5-a487-a6a77f16620d
Cabello, M.
cf2fe279-c6c7-431a-9ddf-6ff548d07458
Caballero, F.
782e983c-76b9-4ec2-8ade-c1dd7399100f
Chatterji, S.
0d10ce3d-518a-4d87-a3bc-6dcb7b365ac6
Cieza, A.
a0df25c5-ee2c-4580-82b3-d0a75591580e
Ayuso-Mateos, J.
a73369d3-3b9c-42c5-a487-a6a77f16620d

Cabello, M., Caballero, F., Chatterji, S., Cieza, A. and Ayuso-Mateos, J. (2014) Risk factors for incidence and persistence of disability in chronic major depression and alcohol use disorders: longitudinal analyses of a population-based study. Health and Quality of Life Outcomes, 12 (1), 186-[24pp]. (doi:10.1186/s12955-014-0186-0). (PMID:25516069)

Record type: Article

Abstract

Background
Major depression and alcohol use disorders are risk factors for incidence of disability. However, it is still unclear whether a chronic course of these health conditions is also prospectively associated with incidence of disability. The aim of the present study was, first, to confirm whether chronic major depression (MD) and alcohol use disorders (AUD) are, respectively, risk factors for persistence and incidence of disability in the general population; and then to analyze the role of help-seeking behavior in the course of disability among respondents with chronic MD and chronic AUD.

Method
Data from two assessments in the National Epidemiologic Survey on Alcohol and Related Conditions were analyzed. Disability was measured by eight domains of the Short Form 12 Health Survey version 2 (SF-12). Generalized estimating equations and logistic regression models were run to estimate risk factors for persistence and incidence of disability, respectively.

Results
Analyses conducted on data from the US general population showed that chronic MD was the strongest risk factor for incidence and persistence of disability in the social functioning, emotional role and mental health domains. Chronic AUD were risk factors for incidence and persistence of disability in the vitality, social functioning, and emotional role domains. Within the group of chronic MD, physical comorbidity and help-seeking were associated with persistent disability in most of the SF-12 domains. Help-seeking behavior was also associated with incidence of problems in the mental health domain for the depression group. Regarding the AUD group, comorbidity with physical health problems was a strong risk factor for persistence of disability in all SF-12 domains. Help-seeking behavior was not related to either persistence or incidence of disability in the chronic alcohol group.

Conclusions
Chronic MD and chronic AUD are independent risk factors for persistence and incidence of disability in the US general population. People with chronic MD seek help for their problems when they experience persistent disability, whereas people with chronic AUD might not seek any help even if they are suffering from persistent disability.

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More information

e-pub ahead of print date: 17 December 2014
Published date: 2014
Keywords: major depression, alcohol use disorders, disability
Organisations: Psychology

Identifiers

Local EPrints ID: 373266
URI: https://eprints.soton.ac.uk/id/eprint/373266
ISSN: 1477-7525
PURE UUID: d773d167-0cc7-43eb-a3ae-875228d92fa6

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Date deposited: 13 Jan 2015 13:54
Last modified: 14 Aug 2019 18:39

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Contributors

Author: M. Cabello
Author: F. Caballero
Author: S. Chatterji
Author: A. Cieza
Author: J. Ayuso-Mateos

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