Risk of fracture in patients with Charcot-Marie-Tooth disease
Risk of fracture in patients with Charcot-Marie-Tooth disease
Introduction: In this study we evaluated fracture risk in patients with Charcot–Marie–Tooth (CMT) disease. Methods: We conducted a retrospective cohort study using the UK Clinical Practice Research Datalink (1987–2012). Each patient with CMT disease was matched with up to 6 patients without a history of CMT disease. The outcome measure was fractures. Results: The risk of non-osteoporotic fracture was statistically significantly increased [adjusted hazard ratio (AHR) 1.47, 95% confidence interval (CI) 1.01–2.14], whereas risk of any and osteoporotic fracture did not reach statistical significance compared with control patients [AHR 1.31 (95% CI 0.98–1.74) and AHR 1.10 (95% CI 0.69–1.74), respectively]. Conclusions: CMT patients have a 1.5-fold increased risk for non-osteoporotic fracture. Studies with larger numbers of CMT patients and with additional data on CMT subtype, bone mineral density, and functional status should be performed to confirm a true association between CMT and an increased risk of fracture.
charcot–marie–tooth disease, cohort study, epidemiology, fracture, osteoporosis
919-924
Pouwels, S.
3d97460d-5b2e-4ec6-b46f-e82e338cf0c1
de Boer, A.
5621b588-a1e0-4827-8940-89efef278f13
Leufkens, H.G.
6f387677-0ec5-408b-bdbc-7a50d49631b6
Weber, W.E.
af82da4f-31c6-432a-9d69-a578c4275bbb
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
de Vries, F.
db4c0543-d6e7-476b-a10e-52d9d483f613
December 2014
Pouwels, S.
3d97460d-5b2e-4ec6-b46f-e82e338cf0c1
de Boer, A.
5621b588-a1e0-4827-8940-89efef278f13
Leufkens, H.G.
6f387677-0ec5-408b-bdbc-7a50d49631b6
Weber, W.E.
af82da4f-31c6-432a-9d69-a578c4275bbb
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
de Vries, F.
db4c0543-d6e7-476b-a10e-52d9d483f613
Pouwels, S., de Boer, A., Leufkens, H.G., Weber, W.E., Cooper, C. and de Vries, F.
(2014)
Risk of fracture in patients with Charcot-Marie-Tooth disease.
Muscle & Nerve, 50 (6), .
(doi:10.1002/mus.24240).
(PMID:24634316)
Abstract
Introduction: In this study we evaluated fracture risk in patients with Charcot–Marie–Tooth (CMT) disease. Methods: We conducted a retrospective cohort study using the UK Clinical Practice Research Datalink (1987–2012). Each patient with CMT disease was matched with up to 6 patients without a history of CMT disease. The outcome measure was fractures. Results: The risk of non-osteoporotic fracture was statistically significantly increased [adjusted hazard ratio (AHR) 1.47, 95% confidence interval (CI) 1.01–2.14], whereas risk of any and osteoporotic fracture did not reach statistical significance compared with control patients [AHR 1.31 (95% CI 0.98–1.74) and AHR 1.10 (95% CI 0.69–1.74), respectively]. Conclusions: CMT patients have a 1.5-fold increased risk for non-osteoporotic fracture. Studies with larger numbers of CMT patients and with additional data on CMT subtype, bone mineral density, and functional status should be performed to confirm a true association between CMT and an increased risk of fracture.
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Published date: December 2014
Keywords:
charcot–marie–tooth disease, cohort study, epidemiology, fracture, osteoporosis
Organisations:
Human Development & Health
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Local EPrints ID: 373844
URI: http://eprints.soton.ac.uk/id/eprint/373844
ISSN: 0148-639X
PURE UUID: 3aeb2bc7-7325-40ae-963a-e3af1e40b1c0
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Date deposited: 02 Feb 2015 13:47
Last modified: 18 Mar 2024 02:45
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Contributors
Author:
S. Pouwels
Author:
A. de Boer
Author:
H.G. Leufkens
Author:
W.E. Weber
Author:
F. de Vries
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