The University of Southampton
University of Southampton Institutional Repository

Risk of fracture in patients with Charcot-Marie-Tooth disease

Risk of fracture in patients with Charcot-Marie-Tooth disease
Risk of fracture in patients with Charcot-Marie-Tooth disease
Introduction: In this study we evaluated fracture risk in patients with Charcot–Marie–Tooth (CMT) disease. Methods: We conducted a retrospective cohort study using the UK Clinical Practice Research Datalink (1987–2012). Each patient with CMT disease was matched with up to 6 patients without a history of CMT disease. The outcome measure was fractures. Results: The risk of non-osteoporotic fracture was statistically significantly increased [adjusted hazard ratio (AHR) 1.47, 95% confidence interval (CI) 1.01–2.14], whereas risk of any and osteoporotic fracture did not reach statistical significance compared with control patients [AHR 1.31 (95% CI 0.98–1.74) and AHR 1.10 (95% CI 0.69–1.74), respectively]. Conclusions: CMT patients have a 1.5-fold increased risk for non-osteoporotic fracture. Studies with larger numbers of CMT patients and with additional data on CMT subtype, bone mineral density, and functional status should be performed to confirm a true association between CMT and an increased risk of fracture.
charcot–marie–tooth disease, cohort study, epidemiology, fracture, osteoporosis
0148-639X
919-924
Pouwels, S.
3d97460d-5b2e-4ec6-b46f-e82e338cf0c1
de Boer, A.
5621b588-a1e0-4827-8940-89efef278f13
Leufkens, H.G.
6f387677-0ec5-408b-bdbc-7a50d49631b6
Weber, W.E.
af82da4f-31c6-432a-9d69-a578c4275bbb
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
de Vries, F.
db4c0543-d6e7-476b-a10e-52d9d483f613
Pouwels, S.
3d97460d-5b2e-4ec6-b46f-e82e338cf0c1
de Boer, A.
5621b588-a1e0-4827-8940-89efef278f13
Leufkens, H.G.
6f387677-0ec5-408b-bdbc-7a50d49631b6
Weber, W.E.
af82da4f-31c6-432a-9d69-a578c4275bbb
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
de Vries, F.
db4c0543-d6e7-476b-a10e-52d9d483f613

Pouwels, S., de Boer, A., Leufkens, H.G., Weber, W.E., Cooper, C. and de Vries, F. (2014) Risk of fracture in patients with Charcot-Marie-Tooth disease. Muscle & Nerve, 50 (6), 919-924. (doi:10.1002/mus.24240). (PMID:24634316)

Record type: Article

Abstract

Introduction: In this study we evaluated fracture risk in patients with Charcot–Marie–Tooth (CMT) disease. Methods: We conducted a retrospective cohort study using the UK Clinical Practice Research Datalink (1987–2012). Each patient with CMT disease was matched with up to 6 patients without a history of CMT disease. The outcome measure was fractures. Results: The risk of non-osteoporotic fracture was statistically significantly increased [adjusted hazard ratio (AHR) 1.47, 95% confidence interval (CI) 1.01–2.14], whereas risk of any and osteoporotic fracture did not reach statistical significance compared with control patients [AHR 1.31 (95% CI 0.98–1.74) and AHR 1.10 (95% CI 0.69–1.74), respectively]. Conclusions: CMT patients have a 1.5-fold increased risk for non-osteoporotic fracture. Studies with larger numbers of CMT patients and with additional data on CMT subtype, bone mineral density, and functional status should be performed to confirm a true association between CMT and an increased risk of fracture.

This record has no associated files available for download.

More information

Published date: December 2014
Keywords: charcot–marie–tooth disease, cohort study, epidemiology, fracture, osteoporosis
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 373844
URI: http://eprints.soton.ac.uk/id/eprint/373844
ISSN: 0148-639X
PURE UUID: 3aeb2bc7-7325-40ae-963a-e3af1e40b1c0
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

Catalogue record

Date deposited: 02 Feb 2015 13:47
Last modified: 18 Mar 2024 02:45

Export record

Altmetrics

Contributors

Author: S. Pouwels
Author: A. de Boer
Author: H.G. Leufkens
Author: W.E. Weber
Author: C. Cooper ORCID iD
Author: F. de Vries

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×