Expression of p57-Kip2 in monocytes and macrophages
Expression of p57-Kip2 in monocytes and macrophages
The p57-Kip2 gene encodes a cyclin-dependent kinase inhibitor and hence this gene has received much attention in the study of malignancy. We have analysed expression of this gene in human monocytes and macrophages. In comparison to CD14++ monocytes, p57-Kip2 expression was higher in both CD14+16+ monocytes and alveolar macrophages. p57-Kip2 expression decreased in CD14++ monocytes after stimulation with lipopolysaccharide but increased after incubation with methylprednisolone. The results indicate that p57-Kip2 may be involved in regulating the inflammatory response of monocytic cells
CDKN1C, inflammation, macrophages, monocytes, p57-Kip2
455-462
Hofer, Thomas P.J.
b7bf7a8b-932b-4fdc-ba75-f4c4cb020eb1
Frankenberger, Marion
55dd9ff6-ea3a-479c-a105-2d4fe5cd81ce
Staples, Karl J.
e0e9d80f-0aed-435f-bd75-0c8818491fee
Ziegler-Heitbrock, Löms
3590463e-64e2-49e5-b482-c8cfb27ee6f6
14 September 2006
Hofer, Thomas P.J.
b7bf7a8b-932b-4fdc-ba75-f4c4cb020eb1
Frankenberger, Marion
55dd9ff6-ea3a-479c-a105-2d4fe5cd81ce
Staples, Karl J.
e0e9d80f-0aed-435f-bd75-0c8818491fee
Ziegler-Heitbrock, Löms
3590463e-64e2-49e5-b482-c8cfb27ee6f6
Hofer, Thomas P.J., Frankenberger, Marion, Staples, Karl J. and Ziegler-Heitbrock, Löms
(2006)
Expression of p57-Kip2 in monocytes and macrophages.
Immunobiology, 211 (6-8), .
(doi:10.1016/j.imbio.2006.05.018).
Abstract
The p57-Kip2 gene encodes a cyclin-dependent kinase inhibitor and hence this gene has received much attention in the study of malignancy. We have analysed expression of this gene in human monocytes and macrophages. In comparison to CD14++ monocytes, p57-Kip2 expression was higher in both CD14+16+ monocytes and alveolar macrophages. p57-Kip2 expression decreased in CD14++ monocytes after stimulation with lipopolysaccharide but increased after incubation with methylprednisolone. The results indicate that p57-Kip2 may be involved in regulating the inflammatory response of monocytic cells
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Published date: 14 September 2006
Keywords:
CDKN1C, inflammation, macrophages, monocytes, p57-Kip2
Organisations:
Faculty of Medicine
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Local EPrints ID: 374400
URI: http://eprints.soton.ac.uk/id/eprint/374400
ISSN: 0171-2985
PURE UUID: dcbb1219-f951-4927-8659-50500fb32842
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Date deposited: 16 Feb 2015 11:39
Last modified: 15 Mar 2024 03:27
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Contributors
Author:
Thomas P.J. Hofer
Author:
Marion Frankenberger
Author:
Löms Ziegler-Heitbrock
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