The University of Southampton
University of Southampton Institutional Repository

Expression of p57-Kip2 in monocytes and macrophages

Expression of p57-Kip2 in monocytes and macrophages
Expression of p57-Kip2 in monocytes and macrophages
The p57-Kip2 gene encodes a cyclin-dependent kinase inhibitor and hence this gene has received much attention in the study of malignancy. We have analysed expression of this gene in human monocytes and macrophages. In comparison to CD14++ monocytes, p57-Kip2 expression was higher in both CD14+16+ monocytes and alveolar macrophages. p57-Kip2 expression decreased in CD14++ monocytes after stimulation with lipopolysaccharide but increased after incubation with methylprednisolone. The results indicate that p57-Kip2 may be involved in regulating the inflammatory response of monocytic cells
CDKN1C, inflammation, macrophages, monocytes, p57-Kip2
0171-2985
455-462
Hofer, Thomas P.J.
b7bf7a8b-932b-4fdc-ba75-f4c4cb020eb1
Frankenberger, Marion
55dd9ff6-ea3a-479c-a105-2d4fe5cd81ce
Staples, Karl J.
e0e9d80f-0aed-435f-bd75-0c8818491fee
Ziegler-Heitbrock, Löms
3590463e-64e2-49e5-b482-c8cfb27ee6f6
Hofer, Thomas P.J.
b7bf7a8b-932b-4fdc-ba75-f4c4cb020eb1
Frankenberger, Marion
55dd9ff6-ea3a-479c-a105-2d4fe5cd81ce
Staples, Karl J.
e0e9d80f-0aed-435f-bd75-0c8818491fee
Ziegler-Heitbrock, Löms
3590463e-64e2-49e5-b482-c8cfb27ee6f6

Hofer, Thomas P.J., Frankenberger, Marion, Staples, Karl J. and Ziegler-Heitbrock, Löms (2006) Expression of p57-Kip2 in monocytes and macrophages. Immunobiology, 211 (6-8), 455-462. (doi:10.1016/j.imbio.2006.05.018).

Record type: Article

Abstract

The p57-Kip2 gene encodes a cyclin-dependent kinase inhibitor and hence this gene has received much attention in the study of malignancy. We have analysed expression of this gene in human monocytes and macrophages. In comparison to CD14++ monocytes, p57-Kip2 expression was higher in both CD14+16+ monocytes and alveolar macrophages. p57-Kip2 expression decreased in CD14++ monocytes after stimulation with lipopolysaccharide but increased after incubation with methylprednisolone. The results indicate that p57-Kip2 may be involved in regulating the inflammatory response of monocytic cells

Full text not available from this repository.

More information

Published date: 14 September 2006
Keywords: CDKN1C, inflammation, macrophages, monocytes, p57-Kip2
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 374400
URI: http://eprints.soton.ac.uk/id/eprint/374400
ISSN: 0171-2985
PURE UUID: dcbb1219-f951-4927-8659-50500fb32842
ORCID for Karl J. Staples: ORCID iD orcid.org/0000-0003-3844-6457

Catalogue record

Date deposited: 16 Feb 2015 11:39
Last modified: 29 Oct 2019 01:48

Export record

Altmetrics

Contributors

Author: Thomas P.J. Hofer
Author: Marion Frankenberger
Author: Karl J. Staples ORCID iD
Author: Löms Ziegler-Heitbrock

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×