The University of Southampton
University of Southampton Institutional Repository

Maternal grand multiparty and the risk of severe mental disorders in adult offspring

Maternal grand multiparty and the risk of severe mental disorders in adult offspring
Maternal grand multiparty and the risk of severe mental disorders in adult offspring
Background: previous studies have shown that maternal grand multiparity may predict an increased risk of mental disorders in young adult offspring, but whether such effects persist throughout adulthood remains unknown. The current study examined if maternal grand multiparity predicts the risks of severe mental disorders, suicides, suicide attempts and dementias throughout adult life.

Methods: our study sample comprised 13243 Helsinki Birth Cohort Study 1934–1944 participants (6905 men and 6338 women). According to hospital birth records, 341 offspring were born to grand multiparous mothers. From Finnish national hospital discharge and causes of death registers, we identified 1682 participants diagnosed with mental disorders during 1969–2010.

Results: maternal grand multiparity predicted significantly increased risks of mood disorders (Hazard Ratio = 1.64, p = 0.03), non-psychotic mood disorders (Hazard Ratio = 2.02, p = 0.002), and suicide attempts (Hazard Ratio = 3.94, p = 0.01) in adult offspring. Furthermore, women born to grand multiparous mothers had significantly increased risks of any severe mental disorder (Hazard Ratio = 1.79, p = 0.01), non-psychotic substance use disorders (Hazard Ratio = 2.77, p = 0.02) schizophrenia, schizotypal and delusional disorders (Hazard Ratio = 2.40, p = 0.02), mood disorders (Hazard Ratio = 2.40, p = 0.002), non-psychotic mood disorders (Hazard Ratio = 2.91, p<0.001), and suicide attempts (Hazard Ratio = 5.05, p = 0.01) in adulthood. The effects of maternal grand multiparity on offspring psychopathology risk were independent of maternal age and body mass index at childbirth, and of year of birth, sex, childhood socioeconomic position, and birth weight of the offspring. In contrast, no significant effects were found among men.

Conclusions: women born to grand multiparous mothers are at an increased risk of severe mental disorders and suicide attempts across adulthood. Our findings may inform the development of preventive interventions for mental disorders
1932-6203
e114679
Lahti, M.
e03f7633-de06-4679-b6d1-58919cf06e80
Eriksson, J.G.
eda300d2-b247-479f-95b9-f12d2c72e92b
Heinonen, K.
667793ce-59c1-43d0-9f53-4f7790a9ed94
Kajantie, E.
d4e32f85-9988-4b83-b353-012210ea0151
Lahti, J.
522c081a-8ed6-476a-b421-f07e9c498ecb
Wahlbeck, K.
80c3bbb7-d95a-42d3-baf1-3ea728ae68b1
Tuovinen, S.
3a4d8d1f-1eae-48a2-afcf-65baad23ead8
Pesonen, A.K.
edd22dbe-e07d-4212-a476-aaff63f619f5
Mikkonen, M.
72e4cbae-6463-4918-b1de-cd5ab54b4802
Osmond, C.
2677bf85-494f-4a78-adf8-580e1b8acb81
Raikkonen, K.
926aba17-06cd-417b-b20f-ae400a2596a6
Lahti, M.
e03f7633-de06-4679-b6d1-58919cf06e80
Eriksson, J.G.
eda300d2-b247-479f-95b9-f12d2c72e92b
Heinonen, K.
667793ce-59c1-43d0-9f53-4f7790a9ed94
Kajantie, E.
d4e32f85-9988-4b83-b353-012210ea0151
Lahti, J.
522c081a-8ed6-476a-b421-f07e9c498ecb
Wahlbeck, K.
80c3bbb7-d95a-42d3-baf1-3ea728ae68b1
Tuovinen, S.
3a4d8d1f-1eae-48a2-afcf-65baad23ead8
Pesonen, A.K.
edd22dbe-e07d-4212-a476-aaff63f619f5
Mikkonen, M.
72e4cbae-6463-4918-b1de-cd5ab54b4802
Osmond, C.
2677bf85-494f-4a78-adf8-580e1b8acb81
Raikkonen, K.
926aba17-06cd-417b-b20f-ae400a2596a6

Lahti, M., Eriksson, J.G., Heinonen, K., Kajantie, E., Lahti, J., Wahlbeck, K., Tuovinen, S., Pesonen, A.K., Mikkonen, M., Osmond, C. and Raikkonen, K. (2014) Maternal grand multiparty and the risk of severe mental disorders in adult offspring. PLoS ONE, 9 (12), e114679. (doi:10.1371/journal.pone.0114679.). (PMID:25493431)

Record type: Article

Abstract

Background: previous studies have shown that maternal grand multiparity may predict an increased risk of mental disorders in young adult offspring, but whether such effects persist throughout adulthood remains unknown. The current study examined if maternal grand multiparity predicts the risks of severe mental disorders, suicides, suicide attempts and dementias throughout adult life.

Methods: our study sample comprised 13243 Helsinki Birth Cohort Study 1934–1944 participants (6905 men and 6338 women). According to hospital birth records, 341 offspring were born to grand multiparous mothers. From Finnish national hospital discharge and causes of death registers, we identified 1682 participants diagnosed with mental disorders during 1969–2010.

Results: maternal grand multiparity predicted significantly increased risks of mood disorders (Hazard Ratio = 1.64, p = 0.03), non-psychotic mood disorders (Hazard Ratio = 2.02, p = 0.002), and suicide attempts (Hazard Ratio = 3.94, p = 0.01) in adult offspring. Furthermore, women born to grand multiparous mothers had significantly increased risks of any severe mental disorder (Hazard Ratio = 1.79, p = 0.01), non-psychotic substance use disorders (Hazard Ratio = 2.77, p = 0.02) schizophrenia, schizotypal and delusional disorders (Hazard Ratio = 2.40, p = 0.02), mood disorders (Hazard Ratio = 2.40, p = 0.002), non-psychotic mood disorders (Hazard Ratio = 2.91, p<0.001), and suicide attempts (Hazard Ratio = 5.05, p = 0.01) in adulthood. The effects of maternal grand multiparity on offspring psychopathology risk were independent of maternal age and body mass index at childbirth, and of year of birth, sex, childhood socioeconomic position, and birth weight of the offspring. In contrast, no significant effects were found among men.

Conclusions: women born to grand multiparous mothers are at an increased risk of severe mental disorders and suicide attempts across adulthood. Our findings may inform the development of preventive interventions for mental disorders

Text
SWS draft RF paper FINAL 12 NOV 2014.docx - Accepted Manuscript
Download (85kB)
Other
fetchObject.action_uri=info_doi%2F10.1371%2Fjournal.pone.0114679&representation=PDF - Version of Record
Available under License Creative Commons Attribution.
Download (596kB)

More information

Accepted/In Press date: 12 November 2014
Published date: 10 December 2014
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 374646
URI: http://eprints.soton.ac.uk/id/eprint/374646
ISSN: 1932-6203
PURE UUID: 9926c658-b619-48f7-97fc-c4684d741760
ORCID for C. Osmond: ORCID iD orcid.org/0000-0002-9054-4655

Catalogue record

Date deposited: 26 Feb 2015 09:40
Last modified: 15 Mar 2024 02:50

Export record

Altmetrics

Contributors

Author: M. Lahti
Author: J.G. Eriksson
Author: K. Heinonen
Author: E. Kajantie
Author: J. Lahti
Author: K. Wahlbeck
Author: S. Tuovinen
Author: A.K. Pesonen
Author: M. Mikkonen
Author: C. Osmond ORCID iD
Author: K. Raikkonen

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×