The University of Southampton
University of Southampton Institutional Repository

Oscillatory underpinnings of mismatch negativity and their relationship with cognitive function in patients with schizophrenia

Oscillatory underpinnings of mismatch negativity and their relationship with cognitive function in patients with schizophrenia
Oscillatory underpinnings of mismatch negativity and their relationship with cognitive function in patients with schizophrenia
Background

Impairments in mismatch negativity (MMN) generation have been consistently reported in patients with schizophrenia. However, underlying oscillatory activity of MMN deficits in schizophrenia and the relationship with cognitive impairments have not been investigated in detail. Time-frequency power and phase analyses can provide more detailed measures of brain dynamics of MMN deficits in schizophrenia.

Method

21 patients with schizophrenia and 21 healthy controls were tested with a roving frequency paradigm to generate MMN. Time-frequency domain power and phase-locking (PL) analysis was performed on all trials using short-time Fourier transforms with Hanning window tapering. A comprehensive battery (CANTAB) was used to assess neurocognitive functioning.

Results

Mean MMN amplitude was significantly lower in patients with schizophrenia (95% CI 0.18 - 0.77). Patients showed significantly lower EEG power (95% CI -1.02 - -0.014) in the ~4-7 Hz frequency range (theta band) between 170 and 210 ms. Patients with schizophrenia showed cognitive impairment in multiple domains of CANTAB. However, MMN impairments in amplitude and power were not correlated with clinical measures, medication dose, social functioning or neurocognitive performance.

Conclusion

The findings from this study suggested that while MMN may be a useful marker to probe NMDA receptor mediated mechanisms and associated impairments in gain control and perceptual changes, it may not be a useful marker in association with clinical or cognitive changes. Trial-by-trial EEG power analysis can be used as a measure of brain dynamics underlying MMN deficits which also can have implications for the use of MMN as a biomarker for drug discovery.
1932-6203
e83255
Burne, Thomas
63076a3a-6c92-47e3-bd2d-7711fe8ed931
Kaser, Muzaffer
778cfb2c-da5f-4fc4-ab36-9b3745a29e12
Soltesz, Fruzsina
cbc12e4b-9d6f-4c24-8203-47ae2bd8f470
Lawrence, Phil
925e666e-1ddd-4aaa-ba9c-388dc24fe9a6
Miller, Sam
d1210662-75ea-4009-9500-7dd8173f6aee
Dodds, Chris
40f9ec16-f5e4-47f5-ad97-163c4b1cb590
Croft, Rodney
82446778-fd24-4da1-93f3-4790111d1760
Dudas, Robert B.
7b2f9c19-efbc-4d47-bbc4-f20668d616d9
Zaman, Rashid
b11db72d-b9f1-48c8-8d03-80ec0b54fec5
Fernandez-Egea, Emilio
0ffd039e-c4f9-4530-b049-48e77829278c
Müller, Ulrich
5389a6d4-a28e-4d4b-929f-c9542af406bd
Dean, Anna
b0e6d829-c351-4d38-8591-58c0db1cefe0
Bullmore, Edward T.
f2fa4f13-15e7-4d71-a4ca-f66d291a31a8
Nathan, Pradeep J.
8862816e-472e-49b4-9c74-c89faffd7f10
Burne, Thomas
63076a3a-6c92-47e3-bd2d-7711fe8ed931
Kaser, Muzaffer
778cfb2c-da5f-4fc4-ab36-9b3745a29e12
Soltesz, Fruzsina
cbc12e4b-9d6f-4c24-8203-47ae2bd8f470
Lawrence, Phil
925e666e-1ddd-4aaa-ba9c-388dc24fe9a6
Miller, Sam
d1210662-75ea-4009-9500-7dd8173f6aee
Dodds, Chris
40f9ec16-f5e4-47f5-ad97-163c4b1cb590
Croft, Rodney
82446778-fd24-4da1-93f3-4790111d1760
Dudas, Robert B.
7b2f9c19-efbc-4d47-bbc4-f20668d616d9
Zaman, Rashid
b11db72d-b9f1-48c8-8d03-80ec0b54fec5
Fernandez-Egea, Emilio
0ffd039e-c4f9-4530-b049-48e77829278c
Müller, Ulrich
5389a6d4-a28e-4d4b-929f-c9542af406bd
Dean, Anna
b0e6d829-c351-4d38-8591-58c0db1cefe0
Bullmore, Edward T.
f2fa4f13-15e7-4d71-a4ca-f66d291a31a8
Nathan, Pradeep J.
8862816e-472e-49b4-9c74-c89faffd7f10

Burne, Thomas, Kaser, Muzaffer, Soltesz, Fruzsina, Lawrence, Phil, Miller, Sam, Dodds, Chris, Croft, Rodney, Dudas, Robert B., Zaman, Rashid, Fernandez-Egea, Emilio, Müller, Ulrich, Dean, Anna, Bullmore, Edward T. and Nathan, Pradeep J. (2013) Oscillatory underpinnings of mismatch negativity and their relationship with cognitive function in patients with schizophrenia. PLoS ONE, 8 (12), e83255. (doi:10.1371/journal.pone.0083255). (PMID:24358266)

Record type: Article

Abstract

Background

Impairments in mismatch negativity (MMN) generation have been consistently reported in patients with schizophrenia. However, underlying oscillatory activity of MMN deficits in schizophrenia and the relationship with cognitive impairments have not been investigated in detail. Time-frequency power and phase analyses can provide more detailed measures of brain dynamics of MMN deficits in schizophrenia.

Method

21 patients with schizophrenia and 21 healthy controls were tested with a roving frequency paradigm to generate MMN. Time-frequency domain power and phase-locking (PL) analysis was performed on all trials using short-time Fourier transforms with Hanning window tapering. A comprehensive battery (CANTAB) was used to assess neurocognitive functioning.

Results

Mean MMN amplitude was significantly lower in patients with schizophrenia (95% CI 0.18 - 0.77). Patients showed significantly lower EEG power (95% CI -1.02 - -0.014) in the ~4-7 Hz frequency range (theta band) between 170 and 210 ms. Patients with schizophrenia showed cognitive impairment in multiple domains of CANTAB. However, MMN impairments in amplitude and power were not correlated with clinical measures, medication dose, social functioning or neurocognitive performance.

Conclusion

The findings from this study suggested that while MMN may be a useful marker to probe NMDA receptor mediated mechanisms and associated impairments in gain control and perceptual changes, it may not be a useful marker in association with clinical or cognitive changes. Trial-by-trial EEG power analysis can be used as a measure of brain dynamics underlying MMN deficits which also can have implications for the use of MMN as a biomarker for drug discovery.

Other
fetchObject.action_uri=info_doi%2F10.1371%2Fjournal.pone.0083255&representation=PDF - Version of Record
Available under License Creative Commons Attribution.
Download (958kB)

More information

Accepted/In Press date: 31 October 2013
Published date: 17 December 2013
Organisations: Psychology

Identifiers

Local EPrints ID: 375327
URI: https://eprints.soton.ac.uk/id/eprint/375327
ISSN: 1932-6203
PURE UUID: 1a2c945c-cc21-4644-b5f1-3ea9e4051813

Catalogue record

Date deposited: 20 Mar 2015 15:27
Last modified: 14 Aug 2019 18:38

Export record

Altmetrics

Contributors

Author: Thomas Burne
Author: Muzaffer Kaser
Author: Fruzsina Soltesz
Author: Phil Lawrence
Author: Sam Miller
Author: Chris Dodds
Author: Rodney Croft
Author: Robert B. Dudas
Author: Rashid Zaman
Author: Emilio Fernandez-Egea
Author: Ulrich Müller
Author: Anna Dean
Author: Edward T. Bullmore
Author: Pradeep J. Nathan

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×