Effects of the BDNF Val66Met polymorphism and met allele load on declarative memory related neural networks
Effects of the BDNF Val66Met polymorphism and met allele load on declarative memory related neural networks
It has been suggested that the BDNF Val66Met polymorphism modulates episodic memory performance via effects on hippocampal neural circuitry. However, fMRI studies have yielded inconsistent results in this respect. Moreover, very few studies have examined the effect of met allele load on activation of memory circuitry. In the present study, we carried out a comprehensive analysis of the effects of the BDNF polymorphism on brain responses during episodic memory encoding and retrieval, including an investigation of the effect of met allele load on memory related activation in the medial temporal lobe. In contrast to previous studies, we found no evidence for an effect of BDNF genotype or met load during episodic memory encoding. Met allele carriers showed increased activation during successful retrieval in right hippocampus but this was contrast-specific and unaffected by met allele load. These results suggest that the BDNF Val66Met polymorphism does not, as previously claimed, exert an observable effect on neural systems underlying encoding of new information into episodic memory but may exert a subtle effect on the efficiency with which such information can be retrieved.
1-9
Verdejo García, Antonio
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Dodds, Chris M.
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Henson, Richard N.
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Suckling, John
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Miskowiak, Kamilla W.
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Ooi, Cinly
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Tait, Roger
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Soltesz, Fruzsina
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Lawrence, Phil
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Bentley, Graham
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Maltby, Kay
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Skeggs, Andrew
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Miller, Sam R.
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McHugh, Simon
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Bullmore, Edward T.
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Nathan, Pradeep J.
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11 November 2013
Verdejo García, Antonio
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Dodds, Chris M.
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Henson, Richard N.
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Suckling, John
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Miskowiak, Kamilla W.
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Ooi, Cinly
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Tait, Roger
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Soltesz, Fruzsina
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Lawrence, Phil
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Bentley, Graham
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Maltby, Kay
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Skeggs, Andrew
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Miller, Sam R.
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McHugh, Simon
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Bullmore, Edward T.
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Nathan, Pradeep J.
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Verdejo García, Antonio, Dodds, Chris M., Henson, Richard N., Suckling, John, Miskowiak, Kamilla W., Ooi, Cinly, Tait, Roger, Soltesz, Fruzsina, Lawrence, Phil, Bentley, Graham, Maltby, Kay, Skeggs, Andrew, Miller, Sam R., McHugh, Simon, Bullmore, Edward T. and Nathan, Pradeep J.
(2013)
Effects of the BDNF Val66Met polymorphism and met allele load on declarative memory related neural networks.
PLoS ONE, 8 (11), .
(doi:10.1371/journal.pone.0074133).
(PMID:24244264)
Abstract
It has been suggested that the BDNF Val66Met polymorphism modulates episodic memory performance via effects on hippocampal neural circuitry. However, fMRI studies have yielded inconsistent results in this respect. Moreover, very few studies have examined the effect of met allele load on activation of memory circuitry. In the present study, we carried out a comprehensive analysis of the effects of the BDNF polymorphism on brain responses during episodic memory encoding and retrieval, including an investigation of the effect of met allele load on memory related activation in the medial temporal lobe. In contrast to previous studies, we found no evidence for an effect of BDNF genotype or met load during episodic memory encoding. Met allele carriers showed increased activation during successful retrieval in right hippocampus but this was contrast-specific and unaffected by met allele load. These results suggest that the BDNF Val66Met polymorphism does not, as previously claimed, exert an observable effect on neural systems underlying encoding of new information into episodic memory but may exert a subtle effect on the efficiency with which such information can be retrieved.
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Accepted/In Press date: 28 July 2013
Published date: 11 November 2013
Organisations:
Psychology
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Local EPrints ID: 375329
URI: http://eprints.soton.ac.uk/id/eprint/375329
ISSN: 1932-6203
PURE UUID: fb4afa06-3b57-4578-a68a-7f842de6ac86
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Date deposited: 20 Mar 2015 15:37
Last modified: 14 Mar 2024 19:24
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Contributors
Author:
Antonio Verdejo García
Author:
Chris M. Dodds
Author:
Richard N. Henson
Author:
John Suckling
Author:
Kamilla W. Miskowiak
Author:
Cinly Ooi
Author:
Roger Tait
Author:
Fruzsina Soltesz
Author:
Phil Lawrence
Author:
Graham Bentley
Author:
Kay Maltby
Author:
Andrew Skeggs
Author:
Sam R. Miller
Author:
Simon McHugh
Author:
Edward T. Bullmore
Author:
Pradeep J. Nathan
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