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Late cortical plasticity in motor and auditory cortex: role of met-allele in BDNF Val66Met polymorphism

Late cortical plasticity in motor and auditory cortex: role of met-allele in BDNF Val66Met polymorphism
Late cortical plasticity in motor and auditory cortex: role of met-allele in BDNF Val66Met polymorphism
The brain-derived neurotropic factor (BDNF) Val66Met polymorphism has been associated with abnormalities of synaptic plasticity in animal models, and abnormalities in motor cortical plasticity have also been described in humans using transcranial direct current stimulation. No study has yet been done on plasticity in non-motor regions, and the effect of two Met alleles (i.e. ‘Met dose’) is not well understood. We studied the effect of the BDNF Val66Met polymorphism on the after-effects of transcranial direct current stimulation and tetanic auditory stimulation in 65 subjects (23; Val66Val, 22; Val66Met and 20; Met66Met genotypes). In the first session, motor evoked potentials (MEP) were recorded under stereotaxic guidance for 90 min after 9 min of anodal transcranial direct current stimulation (TDCS). In the second session, auditory-evoked potentials (AEP) were recorded before and after 2 min of auditory 13 Hz tetanic stimulation. There was a difference in MEP facilitation post-TDCS comparing Met carriers with non-Met carriers, with Met carriers having a modest late facilitation at 30–90 min. There was no difference in responses between Val66Met genotype and Met66Met genotype subjects. Tetanic auditory stimulation also produced late facilitation of N1-P2 AEP at 25 min, but there was no apparent effect of genetic status. This study indicates that Met66Met carriers behave like Val66Met carriers for TDCS-induced plasticity, and produce a late facilitation of MEPs. Auditory cortical plasticity was not affected by the BDNF Val66Met polymorphism. This study sheds light on the differences between auditory and motor cortical plasticity and the role of the BDNF Val66Met polymorphism.
BDNF, event related potential, plasticity, transcranial magnetic stimulation, transcranial direct current stimulation
1461-1457
705-713
Teo, James T. H.
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Bentley, Graham
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Lawrence, Philip
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Soltesz, Fruzsina
cbc12e4b-9d6f-4c24-8203-47ae2bd8f470
Miller, Sam
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Willé, David
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McHugh, Simon
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Dodds, Chris
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Lu, Bai
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Croft, Rodney J.
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Bullmore, Edward T.
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Nathan, Pradeep J.
8862816e-472e-49b4-9c74-c89faffd7f10
Teo, James T. H.
8b2b968b-69aa-466d-a6ec-659c3dc4e118
Bentley, Graham
605e7f38-4c33-4092-bb9c-476324d8a91c
Lawrence, Philip
b1d14c21-8e67-4ba6-abbd-bc3678a538a6
Soltesz, Fruzsina
cbc12e4b-9d6f-4c24-8203-47ae2bd8f470
Miller, Sam
d1210662-75ea-4009-9500-7dd8173f6aee
Willé, David
5328c128-2d2f-4516-aa15-22a29d5713e4
McHugh, Simon
27667963-6ae1-4fd6-9009-6d03d8911421
Dodds, Chris
40f9ec16-f5e4-47f5-ad97-163c4b1cb590
Lu, Bai
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Croft, Rodney J.
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Bullmore, Edward T.
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Nathan, Pradeep J.
8862816e-472e-49b4-9c74-c89faffd7f10

Teo, James T. H., Bentley, Graham, Lawrence, Philip, Soltesz, Fruzsina, Miller, Sam, Willé, David, McHugh, Simon, Dodds, Chris, Lu, Bai, Croft, Rodney J., Bullmore, Edward T. and Nathan, Pradeep J. (2014) Late cortical plasticity in motor and auditory cortex: role of met-allele in BDNF Val66Met polymorphism. International Journal of Neuropsychopharmacology, 17 (5), 705-713. (doi:10.1017/S1461145713001636). (PMID:24405657)

Record type: Article

Abstract

The brain-derived neurotropic factor (BDNF) Val66Met polymorphism has been associated with abnormalities of synaptic plasticity in animal models, and abnormalities in motor cortical plasticity have also been described in humans using transcranial direct current stimulation. No study has yet been done on plasticity in non-motor regions, and the effect of two Met alleles (i.e. ‘Met dose’) is not well understood. We studied the effect of the BDNF Val66Met polymorphism on the after-effects of transcranial direct current stimulation and tetanic auditory stimulation in 65 subjects (23; Val66Val, 22; Val66Met and 20; Met66Met genotypes). In the first session, motor evoked potentials (MEP) were recorded under stereotaxic guidance for 90 min after 9 min of anodal transcranial direct current stimulation (TDCS). In the second session, auditory-evoked potentials (AEP) were recorded before and after 2 min of auditory 13 Hz tetanic stimulation. There was a difference in MEP facilitation post-TDCS comparing Met carriers with non-Met carriers, with Met carriers having a modest late facilitation at 30–90 min. There was no difference in responses between Val66Met genotype and Met66Met genotype subjects. Tetanic auditory stimulation also produced late facilitation of N1-P2 AEP at 25 min, but there was no apparent effect of genetic status. This study indicates that Met66Met carriers behave like Val66Met carriers for TDCS-induced plasticity, and produce a late facilitation of MEPs. Auditory cortical plasticity was not affected by the BDNF Val66Met polymorphism. This study sheds light on the differences between auditory and motor cortical plasticity and the role of the BDNF Val66Met polymorphism.

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More information

Accepted/In Press date: 3 December 2013
e-pub ahead of print date: 9 January 2014
Published date: 1 May 2014
Keywords: BDNF, event related potential, plasticity, transcranial magnetic stimulation, transcranial direct current stimulation
Organisations: Psychology

Identifiers

Local EPrints ID: 375330
URI: https://eprints.soton.ac.uk/id/eprint/375330
ISSN: 1461-1457
PURE UUID: a0ee5130-de31-4321-8b7a-b0090f5bf000

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Date deposited: 20 Mar 2015 16:53
Last modified: 15 Jul 2019 21:26

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Contributors

Author: James T. H. Teo
Author: Graham Bentley
Author: Philip Lawrence
Author: Fruzsina Soltesz
Author: Sam Miller
Author: David Willé
Author: Simon McHugh
Author: Chris Dodds
Author: Bai Lu
Author: Rodney J. Croft
Author: Edward T. Bullmore
Author: Pradeep J. Nathan

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