Achilles tendinopathy following Kaletra(lopinavir/ritonavir) use
Achilles tendinopathy following Kaletra(lopinavir/ritonavir) use
A multitude of rheumatologic manifestations have been associated with HIV infection and protease inhibitors use. We describe two cases that display a temporal relationship between initiating Kaletra and developing Achilles tendinopathy. Immediate and dramatic resolution of symptoms occurred on switching from Kaletra to an alternative agent. Clinicians may want to consider a trial of an alternative agent in individuals on Kaletra who experience Achilles tendinopathy. Adverse events must be formally reported so that our understanding of antiretrovirals may continually evolve and aid decisions about antiretroviral prescribing.
hiv, aids, antiretroviral therapy, treatment, toxicity, Achilles tendinopathy, tendinitis, kaletra, loppinavir, protease inhibitors
833-835
Cresswell, F.V.
9e198b5d-59d3-4653-a3b5-fbd490ec92dc
Tomlins, J.
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Churchill, D.R.
4e1ffac3-8a80-47de-831f-ba98dbe04b7e
Walker-Bone, K.
ad7d1336-ed2c-4f39-ade5-da84eb412109
Richardson, D.
9dedf3b7-54a6-4068-b9ba-f71b70b1d813
October 2014
Cresswell, F.V.
9e198b5d-59d3-4653-a3b5-fbd490ec92dc
Tomlins, J.
a99e0e8e-4ba2-4557-a2ef-e8d9fa60717f
Churchill, D.R.
4e1ffac3-8a80-47de-831f-ba98dbe04b7e
Walker-Bone, K.
ad7d1336-ed2c-4f39-ade5-da84eb412109
Richardson, D.
9dedf3b7-54a6-4068-b9ba-f71b70b1d813
Cresswell, F.V., Tomlins, J., Churchill, D.R., Walker-Bone, K. and Richardson, D.
(2014)
Achilles tendinopathy following Kaletra(lopinavir/ritonavir) use.
International Journal of STD & AIDS, 25 (11), .
(doi:10.1177/0956462414523403).
(PMID:24516081)
Abstract
A multitude of rheumatologic manifestations have been associated with HIV infection and protease inhibitors use. We describe two cases that display a temporal relationship between initiating Kaletra and developing Achilles tendinopathy. Immediate and dramatic resolution of symptoms occurred on switching from Kaletra to an alternative agent. Clinicians may want to consider a trial of an alternative agent in individuals on Kaletra who experience Achilles tendinopathy. Adverse events must be formally reported so that our understanding of antiretrovirals may continually evolve and aid decisions about antiretroviral prescribing.
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Accepted/In Press date: 14 January 2014
Published date: October 2014
Keywords:
hiv, aids, antiretroviral therapy, treatment, toxicity, Achilles tendinopathy, tendinitis, kaletra, loppinavir, protease inhibitors
Organisations:
Human Development & Health
Identifiers
Local EPrints ID: 375429
URI: http://eprints.soton.ac.uk/id/eprint/375429
PURE UUID: ff777457-fece-497f-ac34-66bb32312458
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Date deposited: 24 Mar 2015 14:03
Last modified: 15 Mar 2024 03:04
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Contributors
Author:
F.V. Cresswell
Author:
J. Tomlins
Author:
D.R. Churchill
Author:
D. Richardson
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