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Further evidence of the developmental origins of osteoarthritis: results from the Hertfordshire Cohort Study

Further evidence of the developmental origins of osteoarthritis: results from the Hertfordshire Cohort Study
Further evidence of the developmental origins of osteoarthritis: results from the Hertfordshire Cohort Study
Investigators have suggested a link between birth weight and both hand and lumbar spine osteoarthritis (OA). In this study, we sought to extend these observations by investigating relationships between growth in early life, and clinical and radiological diagnoses of OA at the hand, knee and hip, among participants from the Hertfordshire Cohort Study. Data were available for 222 men and 222 women. Clinical OA was defined based on American College of Rheumatology criteria. Radiographs were taken of the knees and hips, and graded for the presence of osteophytes and overall Kellgren and Lawrence (KL) score. Lower weight at year one was associated with higher rates of clinical hand OA (OR 1.396, 95% CI 1.05, 1.85, P=0.021). Individuals with lower birth weights were more likely to have hip osteophytes (OR 1.512, 95% CI 1.14, 2.00, P=0.004) and this remained robust after adjustment for confounders. Furthermore, a low weight at one year was also associated with a higher osteophyte number in the lateral compartment of the knee, after adjustment for confounders (OR 1.388, 95% CI 1.01, 1.91, P=0.043). We have found further evidence of a relationship between early life factors and adult OA. These findings accord with previous studies.
453-458
Clynes, M.A.
b860d3b7-12ee-42b8-8cd5-1e1abfccbee2
Parsons, Camille
9730e5c3-0382-4ed7-8eaa-6932ab09ec15
Edwards, M.H.
b81ff294-1d16-4a1b-af14-9374c5989d4c
Jameson, K.A.
d5fb142d-06af-456e-9016-17497f94e9f2
Harvey, N.C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Sayer, A.A.
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Dennison, E.M.
ee647287-edb4-4392-8361-e59fd505b1d1
Clynes, M.A.
b860d3b7-12ee-42b8-8cd5-1e1abfccbee2
Parsons, Camille
9730e5c3-0382-4ed7-8eaa-6932ab09ec15
Edwards, M.H.
b81ff294-1d16-4a1b-af14-9374c5989d4c
Jameson, K.A.
d5fb142d-06af-456e-9016-17497f94e9f2
Harvey, N.C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Sayer, A.A.
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Dennison, E.M.
ee647287-edb4-4392-8361-e59fd505b1d1

Clynes, M.A., Parsons, Camille, Edwards, M.H., Jameson, K.A., Harvey, N.C., Sayer, A.A., Cooper, C. and Dennison, E.M. (2014) Further evidence of the developmental origins of osteoarthritis: results from the Hertfordshire Cohort Study. Journal of Developmental Origins of Health and Disease, 5 (6), 453-458. (doi:10.1017/S2040174414000373). (PMID:25154411)

Record type: Article

Abstract

Investigators have suggested a link between birth weight and both hand and lumbar spine osteoarthritis (OA). In this study, we sought to extend these observations by investigating relationships between growth in early life, and clinical and radiological diagnoses of OA at the hand, knee and hip, among participants from the Hertfordshire Cohort Study. Data were available for 222 men and 222 women. Clinical OA was defined based on American College of Rheumatology criteria. Radiographs were taken of the knees and hips, and graded for the presence of osteophytes and overall Kellgren and Lawrence (KL) score. Lower weight at year one was associated with higher rates of clinical hand OA (OR 1.396, 95% CI 1.05, 1.85, P=0.021). Individuals with lower birth weights were more likely to have hip osteophytes (OR 1.512, 95% CI 1.14, 2.00, P=0.004) and this remained robust after adjustment for confounders. Furthermore, a low weight at one year was also associated with a higher osteophyte number in the lateral compartment of the knee, after adjustment for confounders (OR 1.388, 95% CI 1.01, 1.91, P=0.043). We have found further evidence of a relationship between early life factors and adult OA. These findings accord with previous studies.

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More information

Accepted/In Press date: 21 July 2014
e-pub ahead of print date: 22 August 2014
Published date: December 2014
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 375432
URI: http://eprints.soton.ac.uk/id/eprint/375432
PURE UUID: 5072f45a-f2be-4d31-8d66-683d30a5ee52
ORCID for M.A. Clynes: ORCID iD orcid.org/0000-0001-7597-7658
ORCID for N.C. Harvey: ORCID iD orcid.org/0000-0002-8194-2512
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for E.M. Dennison: ORCID iD orcid.org/0000-0002-3048-4961

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Date deposited: 26 Mar 2015 12:02
Last modified: 17 Apr 2021 01:56

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