Tumor-stromal interactions in pancreatic cancer
Tumor-stromal interactions in pancreatic cancer
Pancreatic adenocarcinoma has one of the worse prognoses of any cancer with a 5-year survival of only 3%. Pancreatic cancer displays one of the most prominent stromal reactions of all tumors and it is evident that this is a key contributing factor to disease outcome. The tumor microenvironment of pancreatic cancer harbors a wide spectrum of cell types and a complex network of mechanisms which all serve to promote tumor progression. It is clear that the symbiotic relationship between pancreatic cancer cells and stellate cells is the chief factor creating this unique tumor milieu. Pancreatic stellate cells play critical roles in evasion of cancer cell apoptosis, invasion and metastases, angiogenesis, and promotion of an immunosuppressive environment, all key hallmarks of malignancy. Existing treatments for pancreatic cancer focus on targeting the cancer cells rather than the whole tumor, of which cancer cells represent a small proportion. It is now increasingly evident that research targeted towards the interactions between these cell types, ideally at an early stage of tumor development, is imperative in order to propel the way forward to more effective treatments.
pancreatic cancer, microenvironment, tumor stroma
1-7
Tod, Jo
d45d955c-c5dd-40e8-b0cd-f278be8e9f36
Jenei, Veronika
04d82852-7d30-458a-bc0b-f00ae6c5dd52
Thomas, Gareth
2ff54aa9-a766-416b-91ee-cf1c5be74106
Fine, David
ce3d6a77-040e-4aec-a8f5-4c4c22431605
January 2013
Tod, Jo
d45d955c-c5dd-40e8-b0cd-f278be8e9f36
Jenei, Veronika
04d82852-7d30-458a-bc0b-f00ae6c5dd52
Thomas, Gareth
2ff54aa9-a766-416b-91ee-cf1c5be74106
Fine, David
ce3d6a77-040e-4aec-a8f5-4c4c22431605
Abstract
Pancreatic adenocarcinoma has one of the worse prognoses of any cancer with a 5-year survival of only 3%. Pancreatic cancer displays one of the most prominent stromal reactions of all tumors and it is evident that this is a key contributing factor to disease outcome. The tumor microenvironment of pancreatic cancer harbors a wide spectrum of cell types and a complex network of mechanisms which all serve to promote tumor progression. It is clear that the symbiotic relationship between pancreatic cancer cells and stellate cells is the chief factor creating this unique tumor milieu. Pancreatic stellate cells play critical roles in evasion of cancer cell apoptosis, invasion and metastases, angiogenesis, and promotion of an immunosuppressive environment, all key hallmarks of malignancy. Existing treatments for pancreatic cancer focus on targeting the cancer cells rather than the whole tumor, of which cancer cells represent a small proportion. It is now increasingly evident that research targeted towards the interactions between these cell types, ideally at an early stage of tumor development, is imperative in order to propel the way forward to more effective treatments.
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More information
Accepted/In Press date: 25 November 2012
e-pub ahead of print date: 29 November 2012
Published date: January 2013
Keywords:
pancreatic cancer, microenvironment, tumor stroma
Organisations:
Cancer Sciences
Identifiers
Local EPrints ID: 375433
URI: http://eprints.soton.ac.uk/id/eprint/375433
ISSN: 1424-3903
PURE UUID: b47e082a-1775-4251-bf05-0f67bb22c9bf
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Date deposited: 24 Mar 2015 14:24
Last modified: 14 Mar 2024 19:25
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Author:
Jo Tod
Author:
Veronika Jenei
Author:
David Fine
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