The University of Southampton
University of Southampton Institutional Repository

Malaria transmission, infection, and disease at three sites with varied transmission intensity in Uganda: implications for malaria control

Malaria transmission, infection, and disease at three sites with varied transmission intensity in Uganda: implications for malaria control
Malaria transmission, infection, and disease at three sites with varied transmission intensity in Uganda: implications for malaria control
The intensification of control interventions has led to marked reductions in malaria burden in some settings, but not others. To provide a comprehensive description of malaria epidemiology in Uganda, we conducted surveillance studies over 24 months in 100 houses randomly selected from each of three subcounties: Walukuba (peri-urban), Kihihi (rural), and Nagongera (rural). Annual entomological inoculation rate (aEIR) was estimated from monthly Centers for Disease Control and Prevention (CDC) light trap mosquito collections. Children aged 0.5–10 years were provided long-lasting insecticidal nets (LLINs) and followed for measures of parasite prevalence, anemia and malaria incidence. Estimates of aEIR were 2.8, 32.0, and 310 infectious bites per year, and estimates of parasite prevalence 7.4%, 9.3%, and 28.7% for Walukuba, Kihihi, and Nagongera, respectively. Over the 2-year study, malaria incidence per person-years decreased in Walukuba (0.51 versus 0.31, P = 0.001) and increased in Kihihi (0.97 versus 1.93, P < 0.001) and Nagongera (2.33 versus 3.30, P < 0.001). Of 2,582 episodes of malaria, only 8 (0.3%) met criteria for severe disease. The prevalence of anemia was low and not associated with transmission intensity. In our cohorts, where LLINs and prompt effective treatment were provided, the risk of complicated malaria and anemia was extremely low. However, malaria incidence was high and increased over time at the two rural sites, suggesting improved community-wide coverage of LLIN and additional malaria control interventions are needed in Uganda
0002-9637
1-21
Kamya, M.R.
02c638d9-a7e3-4eab-b517-816fd85f40ae
Arinaitwe, E.
f1e52330-2e83-4dbc-8107-45d5dfa8ac26
Wanzira, H.
a53e3a3b-a9a1-4e71-8eb5-a2bd178a14a1
Katureebe, A.
6588cb42-91d0-4bf9-9985-f7e1023913f8
Barusya, C.
8d82619c-934f-4e02-a2b9-85c616220ef5
Kigozi, S.P.
bbf1fbca-e9f4-4db3-8738-c3fb8e87e1fb
Kilama, M.
3b1d7466-3b89-41ab-813e-7c99aaa19944
Tatem, A.J.
6c6de104-a5f9-46e0-bb93-a1a7c980513e
Rosenthal, P.J.
195d9617-8825-4a9e-929c-344b9a9d995a
Drakeley, C.
b418ff6a-b1df-41e5-a7c6-f22f7aeef681
Lindsay, S.W.
237d7104-7316-42e9-8bc6-f111cae77712
Staedke, S.G.
ba3c6ffe-7a9a-439b-9532-465061c2de30
Smith, D.L.
f7c68c42-0bb1-4698-a4bf-da9355a5c10f
Greenhouse, B.
43b19845-a716-4338-b2a2-3358bf9048c8
Dorsey, G.
a99a9713-4279-4c2f-bb7d-8258064d208a
Kamya, M.R.
02c638d9-a7e3-4eab-b517-816fd85f40ae
Arinaitwe, E.
f1e52330-2e83-4dbc-8107-45d5dfa8ac26
Wanzira, H.
a53e3a3b-a9a1-4e71-8eb5-a2bd178a14a1
Katureebe, A.
6588cb42-91d0-4bf9-9985-f7e1023913f8
Barusya, C.
8d82619c-934f-4e02-a2b9-85c616220ef5
Kigozi, S.P.
bbf1fbca-e9f4-4db3-8738-c3fb8e87e1fb
Kilama, M.
3b1d7466-3b89-41ab-813e-7c99aaa19944
Tatem, A.J.
6c6de104-a5f9-46e0-bb93-a1a7c980513e
Rosenthal, P.J.
195d9617-8825-4a9e-929c-344b9a9d995a
Drakeley, C.
b418ff6a-b1df-41e5-a7c6-f22f7aeef681
Lindsay, S.W.
237d7104-7316-42e9-8bc6-f111cae77712
Staedke, S.G.
ba3c6ffe-7a9a-439b-9532-465061c2de30
Smith, D.L.
f7c68c42-0bb1-4698-a4bf-da9355a5c10f
Greenhouse, B.
43b19845-a716-4338-b2a2-3358bf9048c8
Dorsey, G.
a99a9713-4279-4c2f-bb7d-8258064d208a

Kamya, M.R., Arinaitwe, E., Wanzira, H., Katureebe, A., Barusya, C., Kigozi, S.P., Kilama, M., Tatem, A.J., Rosenthal, P.J., Drakeley, C., Lindsay, S.W., Staedke, S.G., Smith, D.L., Greenhouse, B. and Dorsey, G. (2015) Malaria transmission, infection, and disease at three sites with varied transmission intensity in Uganda: implications for malaria control. American Journal of Tropical Medicine and Hygiene, 1-21. (doi:10.4269/ajtmh.14-0312). (PMID:25778501)

Record type: Article

Abstract

The intensification of control interventions has led to marked reductions in malaria burden in some settings, but not others. To provide a comprehensive description of malaria epidemiology in Uganda, we conducted surveillance studies over 24 months in 100 houses randomly selected from each of three subcounties: Walukuba (peri-urban), Kihihi (rural), and Nagongera (rural). Annual entomological inoculation rate (aEIR) was estimated from monthly Centers for Disease Control and Prevention (CDC) light trap mosquito collections. Children aged 0.5–10 years were provided long-lasting insecticidal nets (LLINs) and followed for measures of parasite prevalence, anemia and malaria incidence. Estimates of aEIR were 2.8, 32.0, and 310 infectious bites per year, and estimates of parasite prevalence 7.4%, 9.3%, and 28.7% for Walukuba, Kihihi, and Nagongera, respectively. Over the 2-year study, malaria incidence per person-years decreased in Walukuba (0.51 versus 0.31, P = 0.001) and increased in Kihihi (0.97 versus 1.93, P < 0.001) and Nagongera (2.33 versus 3.30, P < 0.001). Of 2,582 episodes of malaria, only 8 (0.3%) met criteria for severe disease. The prevalence of anemia was low and not associated with transmission intensity. In our cohorts, where LLINs and prompt effective treatment were provided, the risk of complicated malaria and anemia was extremely low. However, malaria incidence was high and increased over time at the two rural sites, suggesting improved community-wide coverage of LLIN and additional malaria control interventions are needed in Uganda

This record has no associated files available for download.

More information

Accepted/In Press date: 9 January 2015
Published date: 16 March 2015
Organisations: Global Env Change & Earth Observation, WorldPop, Population, Health & Wellbeing (PHeW)

Identifiers

Local EPrints ID: 375453
URI: http://eprints.soton.ac.uk/id/eprint/375453
ISSN: 0002-9637
PURE UUID: a17feb29-75cf-4a96-88fd-6027b18120a5
ORCID for A.J. Tatem: ORCID iD orcid.org/0000-0002-7270-941X

Catalogue record

Date deposited: 27 Mar 2015 10:35
Last modified: 15 Mar 2024 03:43

Export record

Altmetrics

Contributors

Author: M.R. Kamya
Author: E. Arinaitwe
Author: H. Wanzira
Author: A. Katureebe
Author: C. Barusya
Author: S.P. Kigozi
Author: M. Kilama
Author: A.J. Tatem ORCID iD
Author: P.J. Rosenthal
Author: C. Drakeley
Author: S.W. Lindsay
Author: S.G. Staedke
Author: D.L. Smith
Author: B. Greenhouse
Author: G. Dorsey

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×