The University of Southampton
University of Southampton Institutional Repository

Role of aldehyde dehydrogenase in hypoxic vasodilator effects of nitrite in rats and humans

Role of aldehyde dehydrogenase in hypoxic vasodilator effects of nitrite in rats and humans
Role of aldehyde dehydrogenase in hypoxic vasodilator effects of nitrite in rats and humans
In human and rat vascular tissue in vitro, hypoxic nitrite-mediated vasodilatation involves ALDH2. In patients with heart failure in vivo the role of this enzyme in nitrite bioactivation is at most modest, suggesting the involvement of other more important mechanisms.
0007-1188
3341-3352
Arif, Sayqa
ed43541d-4eaf-4397-9028-88b9571effff
Borgognone, Alessandra
45d13f2e-6153-4924-9b3e-9b7d4fb975b6
Lin, Erica Lai-Sze
3695e29f-af5d-4b7b-8a96-30f66008a2c6
O'Sullivan, Aine G.
eb63d6eb-d499-408d-a843-5b8bdca3286e
Sharma, Vishal
a0a4c2eb-0f00-426b-8a32-6ba3fa358851
Drury, Nigel E.
87125352-0267-4549-9fd7-b228f3dd4ae3
Menon, Ashvini
457b0b13-b47c-4eb9-9fd9-a330523c69c5
Nightingale, Peter
ee193242-6a0a-4879-a8b4-f936eb92d49b
Mascaro, Jorge
527d7f1a-6df3-411a-a2cf-d32a685d14e9
Bonser, Robert S.
a9b2ab67-2e16-4fae-a264-d0ac2167806d
Horowitz, John D.
c3146a0a-650a-4839-9efb-dfd404dbaa3e
Feelisch, Martin
8c1b9965-8614-4e85-b2c6-458a2e17eafd
Frenneaux, Michael P.
82824b6d-51f1-4b31-9f7a-5b4746d59833
Madhani, Melanie
63a48cca-67b7-41ae-bc79-0f4a166f0750
Arif, Sayqa
ed43541d-4eaf-4397-9028-88b9571effff
Borgognone, Alessandra
45d13f2e-6153-4924-9b3e-9b7d4fb975b6
Lin, Erica Lai-Sze
3695e29f-af5d-4b7b-8a96-30f66008a2c6
O'Sullivan, Aine G.
eb63d6eb-d499-408d-a843-5b8bdca3286e
Sharma, Vishal
a0a4c2eb-0f00-426b-8a32-6ba3fa358851
Drury, Nigel E.
87125352-0267-4549-9fd7-b228f3dd4ae3
Menon, Ashvini
457b0b13-b47c-4eb9-9fd9-a330523c69c5
Nightingale, Peter
ee193242-6a0a-4879-a8b4-f936eb92d49b
Mascaro, Jorge
527d7f1a-6df3-411a-a2cf-d32a685d14e9
Bonser, Robert S.
a9b2ab67-2e16-4fae-a264-d0ac2167806d
Horowitz, John D.
c3146a0a-650a-4839-9efb-dfd404dbaa3e
Feelisch, Martin
8c1b9965-8614-4e85-b2c6-458a2e17eafd
Frenneaux, Michael P.
82824b6d-51f1-4b31-9f7a-5b4746d59833
Madhani, Melanie
63a48cca-67b7-41ae-bc79-0f4a166f0750

Arif, Sayqa, Borgognone, Alessandra, Lin, Erica Lai-Sze, O'Sullivan, Aine G., Sharma, Vishal, Drury, Nigel E., Menon, Ashvini, Nightingale, Peter, Mascaro, Jorge, Bonser, Robert S., Horowitz, John D., Feelisch, Martin, Frenneaux, Michael P. and Madhani, Melanie (2015) Role of aldehyde dehydrogenase in hypoxic vasodilator effects of nitrite in rats and humans. British Journal of Pharmacology, 172, 3341-3352. (doi:10.1111/bph.13122). (PMID:25754766)

Record type: Article

Abstract

In human and rat vascular tissue in vitro, hypoxic nitrite-mediated vasodilatation involves ALDH2. In patients with heart failure in vivo the role of this enzyme in nitrite bioactivation is at most modest, suggesting the involvement of other more important mechanisms.

PDF
2014_Arif_et_al-2015-British_Journal_of_Pharmacology.pdf - Other
Download (985kB)

More information

Accepted/In Press date: 9 February 2015
e-pub ahead of print date: 5 March 2015
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 375464
URI: https://eprints.soton.ac.uk/id/eprint/375464
ISSN: 0007-1188
PURE UUID: befbb85f-abbc-42c8-a4c1-5bd5ac57a74d
ORCID for Martin Feelisch: ORCID iD orcid.org/0000-0003-2320-1158

Catalogue record

Date deposited: 27 Mar 2015 12:21
Last modified: 06 Jun 2018 12:29

Export record

Altmetrics

Contributors

Author: Sayqa Arif
Author: Alessandra Borgognone
Author: Erica Lai-Sze Lin
Author: Aine G. O'Sullivan
Author: Vishal Sharma
Author: Nigel E. Drury
Author: Ashvini Menon
Author: Peter Nightingale
Author: Jorge Mascaro
Author: Robert S. Bonser
Author: John D. Horowitz
Author: Martin Feelisch ORCID iD
Author: Michael P. Frenneaux
Author: Melanie Madhani

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×