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A multimodal MRI study of the hippocampus in medication-naive children with ADHD: what connects ADHD and depression?

A multimodal MRI study of the hippocampus in medication-naive children with ADHD: what connects ADHD and depression?
A multimodal MRI study of the hippocampus in medication-naive children with ADHD: what connects ADHD and depression?
Children with attention-deficit/hyperactivity disorder (ADHD) are at increased risk for developing depression. The neurobiological substrates that convey this risk remain poorly understood. On the basis of considerable data implicating hippocampal abnormalities in depressive disorders, we aimed to explore the relationship between the hippocampus and levels of depressive symptomatology in ADHD. We used magnetic resonance imaging (MRI) to examine the volumes and resting-state functional connectivity of the hippocampus in a sample of 32 medication naive children with ADHD (ages 6 - 13) and 33 age- and sex-matched healthy control (HC) participants. Compared with the HC participants, the participants with ADHD had (i) reduced volumes of the left hippocampus and (ii) reduced functional connectivity between the left hippocampus and the left orbitofrontal cortex (OFC); these hippocampal effects were associated with more severe depressive symptoms, even after controlling for the severity of inattentive and hyperactive/impulsive symptoms. Altered hippocampal structure and connectivity were not associated with anxiety or more general internalizing symptoms. Though preliminary, these findings suggest that the relationship between hippocampal anomalies and ADHD youth's susceptibility to developing depression and other mood disorders may merit further investigation with follow-up longitudinal research.
attention-deficit/hyperactivity disorder, hippocampus, depression, functional connectivity, orbitofrontal cortex
0925-4927
112-118
Posner, Jonathan
3ec42fd6-99f8-4e47-8c37-cfb0e2ec8eec
Siciliano, Francesco
d52edae7-df0c-4d6c-a455-aa5d05c4c255
Wang, Zhishun
0f8f3e1a-9527-4aff-ac4d-452f3cef63fd
Liu, Jun
7f60fa00-ac77-47be-a30b-55de6fee70bb
Sonuga-Barke, Edmund
bc80bf95-6cf9-4c76-a09d-eaaf0b717635
Greenhill, Laurence
de294913-5cec-4f7f-b165-a3317730abae
Posner, Jonathan
3ec42fd6-99f8-4e47-8c37-cfb0e2ec8eec
Siciliano, Francesco
d52edae7-df0c-4d6c-a455-aa5d05c4c255
Wang, Zhishun
0f8f3e1a-9527-4aff-ac4d-452f3cef63fd
Liu, Jun
7f60fa00-ac77-47be-a30b-55de6fee70bb
Sonuga-Barke, Edmund
bc80bf95-6cf9-4c76-a09d-eaaf0b717635
Greenhill, Laurence
de294913-5cec-4f7f-b165-a3317730abae

Posner, Jonathan, Siciliano, Francesco, Wang, Zhishun, Liu, Jun, Sonuga-Barke, Edmund and Greenhill, Laurence (2014) A multimodal MRI study of the hippocampus in medication-naive children with ADHD: what connects ADHD and depression? Psychiatry Research: Neuroimaging, 224 (2), 112-118. (doi:10.1016/j.pscychresns.2014.08.006). (PMID:25220159)

Record type: Article

Abstract

Children with attention-deficit/hyperactivity disorder (ADHD) are at increased risk for developing depression. The neurobiological substrates that convey this risk remain poorly understood. On the basis of considerable data implicating hippocampal abnormalities in depressive disorders, we aimed to explore the relationship between the hippocampus and levels of depressive symptomatology in ADHD. We used magnetic resonance imaging (MRI) to examine the volumes and resting-state functional connectivity of the hippocampus in a sample of 32 medication naive children with ADHD (ages 6 - 13) and 33 age- and sex-matched healthy control (HC) participants. Compared with the HC participants, the participants with ADHD had (i) reduced volumes of the left hippocampus and (ii) reduced functional connectivity between the left hippocampus and the left orbitofrontal cortex (OFC); these hippocampal effects were associated with more severe depressive symptoms, even after controlling for the severity of inattentive and hyperactive/impulsive symptoms. Altered hippocampal structure and connectivity were not associated with anxiety or more general internalizing symptoms. Though preliminary, these findings suggest that the relationship between hippocampal anomalies and ADHD youth's susceptibility to developing depression and other mood disorders may merit further investigation with follow-up longitudinal research.

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Published date: 30 November 2014
Keywords: attention-deficit/hyperactivity disorder, hippocampus, depression, functional connectivity, orbitofrontal cortex
Organisations: Clinical Neuroscience

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Local EPrints ID: 375561
URI: https://eprints.soton.ac.uk/id/eprint/375561
ISSN: 0925-4927
PURE UUID: 736bf95b-84ae-428e-ae73-478245227479

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Date deposited: 30 Mar 2015 13:43
Last modified: 15 Jul 2019 21:25

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Contributors

Author: Jonathan Posner
Author: Francesco Siciliano
Author: Zhishun Wang
Author: Jun Liu
Author: Edmund Sonuga-Barke
Author: Laurence Greenhill

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