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Dysfunctional modulation of default mode network activity in attention-deficit/hyperactivity disorder

Dysfunctional modulation of default mode network activity in attention-deficit/hyperactivity disorder
Dysfunctional modulation of default mode network activity in attention-deficit/hyperactivity disorder
The state regulation deficit model posits that individuals with attention-deficit/hyperactivity disorder (ADHD) have difficulty applying mental effort effectively under suboptimal conditions such as very fast and very slow event rates (ERs). ADHD is also associated with diminished suppression of default mode network (DMN) activity and related performance deficits on tasks requiring effortful engagement. The current study builds on these 2 literatures to test the hypothesis that failure to modulate DMN activity in ADHD might be especially pronounced at ER extremes. Nineteen adults with ADHD and 20 individuals without any neuropsychiatric condition successfully completed a simple target detection task under 3 ER conditions (2-, 4-, and 8-s interstimulus intervals) inside the scanner. Task-related DMN deactivations were compared between 2 groups. There was a differential effect of ER on DMN activity for individuals with ADHD compared to controls. Individuals with ADHD displayed excessive DMN activity at the fast and slow, but not at the moderate ER. The results indicate that DMN attenuation in ADHD is disrupted in suboptimal energetic states where additional effort is required to optimize task engagement. DMN dysregulation may be an important element of the neurobiological underpinnings of state regulation deficits in ADHD
0021-843X
208-214
Metin, Baris
8203cbc4-64ac-406a-8aa7-6e2f43b82ef8
Krebs, Ruth M.
323a3a58-bc24-4e1d-8fbe-5f1af1eddea3
Wiersema, Jan R.
cc91556a-6a9f-4079-b0b8-502bd729b936
Verguts, Tom
6e5335fd-b742-4c58-8dd4-31a37e6c5d46
Gasthuys, Roos
52176d13-9a0b-485e-9627-28c7b763c8ee
van der Meere, Jacob J.
f0f3d2a0-95ef-4029-94c6-2d6e3b3c5b3b
Achten, Eric
a88e206b-8e6c-425b-930f-759e559f130d
Roeyers, Herbert
3554b6b3-e364-4a6a-9e8b-64f5188a6d60
Sonuga-Barke, Edmund
bc80bf95-6cf9-4c76-a09d-eaaf0b717635
Metin, Baris
8203cbc4-64ac-406a-8aa7-6e2f43b82ef8
Krebs, Ruth M.
323a3a58-bc24-4e1d-8fbe-5f1af1eddea3
Wiersema, Jan R.
cc91556a-6a9f-4079-b0b8-502bd729b936
Verguts, Tom
6e5335fd-b742-4c58-8dd4-31a37e6c5d46
Gasthuys, Roos
52176d13-9a0b-485e-9627-28c7b763c8ee
van der Meere, Jacob J.
f0f3d2a0-95ef-4029-94c6-2d6e3b3c5b3b
Achten, Eric
a88e206b-8e6c-425b-930f-759e559f130d
Roeyers, Herbert
3554b6b3-e364-4a6a-9e8b-64f5188a6d60
Sonuga-Barke, Edmund
bc80bf95-6cf9-4c76-a09d-eaaf0b717635

Metin, Baris, Krebs, Ruth M., Wiersema, Jan R., Verguts, Tom, Gasthuys, Roos, van der Meere, Jacob J., Achten, Eric, Roeyers, Herbert and Sonuga-Barke, Edmund (2015) Dysfunctional modulation of default mode network activity in attention-deficit/hyperactivity disorder. The Journal of Abnormal Psychology, 124 (1), 208-214. (doi:10.1037/abn0000013). (PMID:25314265)

Record type: Article

Abstract

The state regulation deficit model posits that individuals with attention-deficit/hyperactivity disorder (ADHD) have difficulty applying mental effort effectively under suboptimal conditions such as very fast and very slow event rates (ERs). ADHD is also associated with diminished suppression of default mode network (DMN) activity and related performance deficits on tasks requiring effortful engagement. The current study builds on these 2 literatures to test the hypothesis that failure to modulate DMN activity in ADHD might be especially pronounced at ER extremes. Nineteen adults with ADHD and 20 individuals without any neuropsychiatric condition successfully completed a simple target detection task under 3 ER conditions (2-, 4-, and 8-s interstimulus intervals) inside the scanner. Task-related DMN deactivations were compared between 2 groups. There was a differential effect of ER on DMN activity for individuals with ADHD compared to controls. Individuals with ADHD displayed excessive DMN activity at the fast and slow, but not at the moderate ER. The results indicate that DMN attenuation in ADHD is disrupted in suboptimal energetic states where additional effort is required to optimize task engagement. DMN dysregulation may be an important element of the neurobiological underpinnings of state regulation deficits in ADHD

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e-pub ahead of print date: 2015
Published date: February 2015
Organisations: Clinical Neuroscience

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Local EPrints ID: 375563
URI: http://eprints.soton.ac.uk/id/eprint/375563
ISSN: 0021-843X
PURE UUID: 796e898b-4ae3-45c5-b1e6-bc2aabfab089

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Date deposited: 30 Mar 2015 13:59
Last modified: 14 Mar 2024 19:28

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Contributors

Author: Baris Metin
Author: Ruth M. Krebs
Author: Jan R. Wiersema
Author: Tom Verguts
Author: Roos Gasthuys
Author: Jacob J. van der Meere
Author: Eric Achten
Author: Herbert Roeyers
Author: Edmund Sonuga-Barke

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