The University of Southampton
University of Southampton Institutional Repository

Higher oily fish consumption in late pregnancy is associated with reduced aortic stiffness in the child at age 9 years

Higher oily fish consumption in late pregnancy is associated with reduced aortic stiffness in the child at age 9 years
Higher oily fish consumption in late pregnancy is associated with reduced aortic stiffness in the child at age 9 years
RATIONALE: Higher pulse wave velocity (PWV) reflects increased arterial stiffness and is an established cardiovascular risk marker associated with lower long-chain n-3 polyunsaturated fatty acid intake in adults. Experimentally, maternal fatty acid intake in pregnancy has lasting effects on offspring arterial stiffness.

OBJECTIVE: To examine the association between maternal consumption of oily fish, a source of long-chain n-3 polyunsaturated fatty acids, in pregnancy and child's aortic stiffness age 9 years.

METHODS AND RESULTS: In a mother-offspring study (Southampton Women's Survey), the child's descending aorta PWV was measured at the age of 9 years using velocity-encoded phase-contrast MRI and related to maternal oily fish consumption assessed prospectively during pregnancy. Higher oily fish consumption in late pregnancy was associated with lower childhood aortic PWV (sex-adjusted ?=-0.084 m/s per portion per week; 95% confidence interval, -0.137 to -0.031; P=0.002; n=226). Mother's educational attainment was independently associated with child's PWV. PWV was not associated with the child's current oily fish consumption.

CONCLUSIONS: Level of maternal oily fish consumption in pregnancy may influence child's large artery development, with potential long-term consequences for later cardiovascular risk.
fatty acids, pregnancy, vascular stiffness
0009-7330
1202-1205
Bryant, J.A.
83de7921-a32f-464b-923c-13c16dca2458
Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Peebles, C.
8eb51995-0f07-46f7-9ca2-f97301fefc3d
Davies, L.
62b6dfd3-69cd-4f3d-9527-a5c70c7c74a8
Inskip, H.M.
5fb4470a-9379-49b2-a533-9da8e61058b7
Robinson, S.M.
ba591c98-4380-456a-be8a-c452f992b69b
Calder, Philip C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Godfrey, K.M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Bryant, J.A.
83de7921-a32f-464b-923c-13c16dca2458
Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Peebles, C.
8eb51995-0f07-46f7-9ca2-f97301fefc3d
Davies, L.
62b6dfd3-69cd-4f3d-9527-a5c70c7c74a8
Inskip, H.M.
5fb4470a-9379-49b2-a533-9da8e61058b7
Robinson, S.M.
ba591c98-4380-456a-be8a-c452f992b69b
Calder, Philip C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Godfrey, K.M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd

Bryant, J.A., Hanson, Mark A., Peebles, C., Davies, L., Inskip, H.M., Robinson, S.M., Calder, Philip C., Cooper, C. and Godfrey, K.M. (2015) Higher oily fish consumption in late pregnancy is associated with reduced aortic stiffness in the child at age 9 years. Circulation Research, 116 (7), 1202-1205. (doi:10.1161/CIRCRESAHA.116.305158). (PMID:25700036)

Record type: Article

Abstract

RATIONALE: Higher pulse wave velocity (PWV) reflects increased arterial stiffness and is an established cardiovascular risk marker associated with lower long-chain n-3 polyunsaturated fatty acid intake in adults. Experimentally, maternal fatty acid intake in pregnancy has lasting effects on offspring arterial stiffness.

OBJECTIVE: To examine the association between maternal consumption of oily fish, a source of long-chain n-3 polyunsaturated fatty acids, in pregnancy and child's aortic stiffness age 9 years.

METHODS AND RESULTS: In a mother-offspring study (Southampton Women's Survey), the child's descending aorta PWV was measured at the age of 9 years using velocity-encoded phase-contrast MRI and related to maternal oily fish consumption assessed prospectively during pregnancy. Higher oily fish consumption in late pregnancy was associated with lower childhood aortic PWV (sex-adjusted ?=-0.084 m/s per portion per week; 95% confidence interval, -0.137 to -0.031; P=0.002; n=226). Mother's educational attainment was independently associated with child's PWV. PWV was not associated with the child's current oily fish consumption.

CONCLUSIONS: Level of maternal oily fish consumption in pregnancy may influence child's large artery development, with potential long-term consequences for later cardiovascular risk.

This record has no associated files available for download.

More information

Accepted/In Press date: 19 February 2015
e-pub ahead of print date: 19 February 2015
Keywords: fatty acids, pregnancy, vascular stiffness
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 375581
URI: http://eprints.soton.ac.uk/id/eprint/375581
ISSN: 0009-7330
PURE UUID: e1968db0-09fc-427a-bf1a-fb8ddf9135f0
ORCID for Mark A. Hanson: ORCID iD orcid.org/0000-0002-6907-613X
ORCID for H.M. Inskip: ORCID iD orcid.org/0000-0001-8897-1749
ORCID for S.M. Robinson: ORCID iD orcid.org/0000-0003-1766-7269
ORCID for Philip C. Calder: ORCID iD orcid.org/0000-0002-6038-710X
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for K.M. Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

Catalogue record

Date deposited: 31 Mar 2015 13:25
Last modified: 18 Mar 2024 02:52

Export record

Altmetrics

Contributors

Author: J.A. Bryant
Author: Mark A. Hanson ORCID iD
Author: C. Peebles
Author: L. Davies
Author: H.M. Inskip ORCID iD
Author: S.M. Robinson ORCID iD
Author: C. Cooper ORCID iD
Author: K.M. Godfrey ORCID iD

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×