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The association of grip strength with severity and duration of Parkinson's: a cross sectional study

The association of grip strength with severity and duration of Parkinson's: a cross sectional study
The association of grip strength with severity and duration of Parkinson's: a cross sectional study
Background: weakness is reported in Parkinson’s but always unadjusted for recognized factors that influence muscle strength such as participants’ age, gender, and body size. This may obscure the true association of Parkinson’s with muscle strength. Objective. To evaluate the relationship between grip strength, Parkinson’s severity, and duration adjusting for these factors.

Methods: age, gender, height, weight, grip strength, Unified Parkinson’s Disease Rating Score (UPDRS) motor score, Hoehn and Yahr (H&Y) stage, disease duration, number of comorbidities and medications, Barthel score, Mini Mental State Examination (MMSE) score, and Malnutrition Universal Screening Tool (MUST) score were recorded.

Results: fifty-seven of 79 (72%) people with Parkinson’s resident in one town were recruited. Age, gender, height, and Parkinson’s severity were the most significant determinants of grip strength. Each unit increase in UPDRS motor score and H&Y stage was associated with lower grip strength in univariate linear regression analyses adjusted for gender: ?0.3 kg strength (95% confidence interval = ?0.51, ?0.09), P = .006 for each additional UPDRS point, and ?3.87 kg strength (95% confidence interval = ?6.54, ?1.21), P = .005 for each additional H&Y stage. Disease duration was not associated with grip strength. In multivariate regression, Parkinson’s severity remained strongly associated with grip strength (UPDRS score P = .09; H&Y stage P = .04).

Conclusions: this is the first demonstration that increasing severity of Parkinson’s was associated with weaker grip after adjustment for known influences on muscle strength. Participants’ age, gender, and body size also had a significant impact on strength. Adjustment of reported values for all these factors is essential to allow accurate reporting of grip strength values in intervention trials and comparison between different groups
1545-9683
1-8
Roberts, Helen C.
5ea688b1-ef7a-4173-9da0-26290e18f253
Syddall, Holly E.
e6081406-7d69-4111-82ab-e859ee966db4
Butchart, Joe W.
51e5e5b0-0c9e-4d68-87d3-00cfc0dbe57b
Stack, Emma L.
55c0fc05-3a75-4c9e-b15f-6022d8edde54
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Aihie Sayer, Avan
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb
Roberts, Helen C.
5ea688b1-ef7a-4173-9da0-26290e18f253
Syddall, Holly E.
e6081406-7d69-4111-82ab-e859ee966db4
Butchart, Joe W.
51e5e5b0-0c9e-4d68-87d3-00cfc0dbe57b
Stack, Emma L.
55c0fc05-3a75-4c9e-b15f-6022d8edde54
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Aihie Sayer, Avan
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb

Roberts, Helen C., Syddall, Holly E., Butchart, Joe W., Stack, Emma L., Cooper, Cyrus and Aihie Sayer, Avan (2015) The association of grip strength with severity and duration of Parkinson's: a cross sectional study. Neurorehabilitation and Neural Repair, 1-8. (doi:10.1177/1545968315570324).

Record type: Article

Abstract

Background: weakness is reported in Parkinson’s but always unadjusted for recognized factors that influence muscle strength such as participants’ age, gender, and body size. This may obscure the true association of Parkinson’s with muscle strength. Objective. To evaluate the relationship between grip strength, Parkinson’s severity, and duration adjusting for these factors.

Methods: age, gender, height, weight, grip strength, Unified Parkinson’s Disease Rating Score (UPDRS) motor score, Hoehn and Yahr (H&Y) stage, disease duration, number of comorbidities and medications, Barthel score, Mini Mental State Examination (MMSE) score, and Malnutrition Universal Screening Tool (MUST) score were recorded.

Results: fifty-seven of 79 (72%) people with Parkinson’s resident in one town were recruited. Age, gender, height, and Parkinson’s severity were the most significant determinants of grip strength. Each unit increase in UPDRS motor score and H&Y stage was associated with lower grip strength in univariate linear regression analyses adjusted for gender: ?0.3 kg strength (95% confidence interval = ?0.51, ?0.09), P = .006 for each additional UPDRS point, and ?3.87 kg strength (95% confidence interval = ?6.54, ?1.21), P = .005 for each additional H&Y stage. Disease duration was not associated with grip strength. In multivariate regression, Parkinson’s severity remained strongly associated with grip strength (UPDRS score P = .09; H&Y stage P = .04).

Conclusions: this is the first demonstration that increasing severity of Parkinson’s was associated with weaker grip after adjustment for known influences on muscle strength. Participants’ age, gender, and body size also had a significant impact on strength. Adjustment of reported values for all these factors is essential to allow accurate reporting of grip strength values in intervention trials and comparison between different groups

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e-pub ahead of print date: 4 February 2015
Published date: 4 February 2015
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 375836
URI: http://eprints.soton.ac.uk/id/eprint/375836
ISSN: 1545-9683
PURE UUID: 1fdf77db-9933-41c8-97f0-1fbf2b907c2c
ORCID for Helen C. Roberts: ORCID iD orcid.org/0000-0002-5291-1880
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709

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Date deposited: 16 Apr 2015 12:56
Last modified: 07 Oct 2020 01:48

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Contributors

Author: Holly E. Syddall
Author: Joe W. Butchart
Author: Emma L. Stack
Author: Cyrus Cooper ORCID iD
Author: Avan Aihie Sayer

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