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Microwave-accelerated O-alkylation of carboxylic acids with O-alkylisoureas

Microwave-accelerated O-alkylation of carboxylic acids with O-alkylisoureas
Microwave-accelerated O-alkylation of carboxylic acids with O-alkylisoureas
Microwave-assisted O-alkylations of several carboxylic acids have been performed with three different O-alkylisoureas. All reactions are significantly faster compared to conventionally heated reactions, while retaining high chemoselectivity. The combination of microwave technology with the use of the solid-supported isourea 3 enables the synthetic chemist to obtain the pure methyl esters starting from the corresponding acids in less than an hour.
2961-2963
Crosignani, Stefano
aaa5cc3f-0b82-4d33-af01-59115c8bdff5
White, Peter D
3bb156f8-0b67-474a-a40a-8c7a3af532cf
Linclau, Bruno
19b9cacd-b8e8-4c65-af36-6352cade84ba
Crosignani, Stefano
aaa5cc3f-0b82-4d33-af01-59115c8bdff5
White, Peter D
3bb156f8-0b67-474a-a40a-8c7a3af532cf
Linclau, Bruno
19b9cacd-b8e8-4c65-af36-6352cade84ba

Crosignani, Stefano, White, Peter D and Linclau, Bruno (2002) Microwave-accelerated O-alkylation of carboxylic acids with O-alkylisoureas. Organic Letters, 4 (17), 2961-2963. (doi:10.1021/ol0263705).

Record type: Article

Abstract

Microwave-assisted O-alkylations of several carboxylic acids have been performed with three different O-alkylisoureas. All reactions are significantly faster compared to conventionally heated reactions, while retaining high chemoselectivity. The combination of microwave technology with the use of the solid-supported isourea 3 enables the synthetic chemist to obtain the pure methyl esters starting from the corresponding acids in less than an hour.

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Published date: 2002
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Identifiers

Local EPrints ID: 37589
URI: http://eprints.soton.ac.uk/id/eprint/37589
DOI: doi:10.1021/ol0263705
PURE UUID: 029bf58c-105d-4863-a155-465d2eda58ab
ORCID for Bruno Linclau: ORCID iD orcid.org/0000-0001-8762-0170

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Date deposited: 24 May 2006
Last modified: 16 Mar 2024 03:15

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Contributors

Author: Stefano Crosignani
Author: Peter D White
Author: Bruno Linclau ORCID iD

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