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Five winters of pneumococcal serotype replacement in UK carriage following PCV introduction

Five winters of pneumococcal serotype replacement in UK carriage following PCV introduction
Five winters of pneumococcal serotype replacement in UK carriage following PCV introduction
The seven-valent pneumococcal conjugate vaccine (PCV7) was added to the UK national immunisation programme in September 2006. PCV13 replaced PCV7 in April 2010. As carriage precedes disease cases this study collected carried pneumococci from children each winter from 2006/7 to 2010/11 over PCV introduction. Conventional microbiology and whole genome sequencing were utilised to characterise pneumococcal strains.

Overall prevalence of pneumococcal carriage remained stable. Vaccine serotypes (VT) decreased (p < 0.0001) with concomitant increases in non-vaccine serotypes (NVT). In winter 2010/11 only one isolate of PCV7 VT was observed (6B). PCV13 unique VTs decreased between winters immediately preceding and following PCV13 introduction (p = 0.04). Significant decreases for VTs 6B, 19F, 23F (PCV7) and 6A (PCV13) and increases for NVT 21, 23B, 33F and 35F were detected. The serotype replacement was accompanied by parallel changes in genotype prevalence for associated sequence types with clonal expansion contributing to replacement. By winter 2010/11, serotype coverage of PCV7 and PCV13 was 1% and 11% respectively.

VT replacement was observed for PCV7 and PCV13 serotypes. Conjugate vaccine design and use requires continuous monitoring and revision.
streptococcus pneumonia, pneumococcal vaccines, serotype replacement, next generation sequencing, whole genome
2015-2021
Gladstone, R.A.
c75d747c-0663-49e3-8d81-4e797eb79d0a
Jefferies, Johanna M.C.
9468e292-0b41-412d-9470-944e257c7bcf
Tocheva, Anna S.
b7da2781-6124-4e4e-9ef1-a98c5a166927
Beard, K.R.
9244b519-eb47-4fa8-bdc7-6f1bebfa04a7
Garley, D.
5179022b-aec7-4e33-8657-dd7f658c49b0
Chong, W.W.
fd34a2f3-e317-4dd2-b371-45fc00258402
Bentley, S.D.
633dc14f-9cef-4fba-b267-83d87a4f45a6
Faust, S.N.
f97df780-9f9b-418e-b349-7adf63e150c1
Clarke, S.C.
f7d7f7a2-4b1f-4b36-883a-0f967e73fb17
Gladstone, R.A.
c75d747c-0663-49e3-8d81-4e797eb79d0a
Jefferies, Johanna M.C.
9468e292-0b41-412d-9470-944e257c7bcf
Tocheva, Anna S.
b7da2781-6124-4e4e-9ef1-a98c5a166927
Beard, K.R.
9244b519-eb47-4fa8-bdc7-6f1bebfa04a7
Garley, D.
5179022b-aec7-4e33-8657-dd7f658c49b0
Chong, W.W.
fd34a2f3-e317-4dd2-b371-45fc00258402
Bentley, S.D.
633dc14f-9cef-4fba-b267-83d87a4f45a6
Faust, S.N.
f97df780-9f9b-418e-b349-7adf63e150c1
Clarke, S.C.
f7d7f7a2-4b1f-4b36-883a-0f967e73fb17

Gladstone, R.A., Jefferies, Johanna M.C., Tocheva, Anna S., Beard, K.R., Garley, D., Chong, W.W., Bentley, S.D., Faust, S.N. and Clarke, S.C. (2015) Five winters of pneumococcal serotype replacement in UK carriage following PCV introduction. Vaccine, 33 (17), 2015-2021. (doi:10.1016/j.vaccine.2015.03.012). (PMID:25776920)

Record type: Article

Abstract

The seven-valent pneumococcal conjugate vaccine (PCV7) was added to the UK national immunisation programme in September 2006. PCV13 replaced PCV7 in April 2010. As carriage precedes disease cases this study collected carried pneumococci from children each winter from 2006/7 to 2010/11 over PCV introduction. Conventional microbiology and whole genome sequencing were utilised to characterise pneumococcal strains.

Overall prevalence of pneumococcal carriage remained stable. Vaccine serotypes (VT) decreased (p < 0.0001) with concomitant increases in non-vaccine serotypes (NVT). In winter 2010/11 only one isolate of PCV7 VT was observed (6B). PCV13 unique VTs decreased between winters immediately preceding and following PCV13 introduction (p = 0.04). Significant decreases for VTs 6B, 19F, 23F (PCV7) and 6A (PCV13) and increases for NVT 21, 23B, 33F and 35F were detected. The serotype replacement was accompanied by parallel changes in genotype prevalence for associated sequence types with clonal expansion contributing to replacement. By winter 2010/11, serotype coverage of PCV7 and PCV13 was 1% and 11% respectively.

VT replacement was observed for PCV7 and PCV13 serotypes. Conjugate vaccine design and use requires continuous monitoring and revision.

Full text not available from this repository.

More information

Accepted/In Press date: 5 March 2015
e-pub ahead of print date: 14 March 2015
Published date: 21 April 2015
Keywords: streptococcus pneumonia, pneumococcal vaccines, serotype replacement, next generation sequencing, whole genome
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 375909
URI: http://eprints.soton.ac.uk/id/eprint/375909
PURE UUID: cec68782-dfad-42f1-91d8-c77fa8979b6f
ORCID for S.N. Faust: ORCID iD orcid.org/0000-0003-3410-7642
ORCID for S.C. Clarke: ORCID iD orcid.org/0000-0002-7009-1548

Catalogue record

Date deposited: 20 Apr 2015 12:51
Last modified: 18 Feb 2021 17:08

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Contributors

Author: R.A. Gladstone
Author: Johanna M.C. Jefferies
Author: Anna S. Tocheva
Author: K.R. Beard
Author: D. Garley
Author: W.W. Chong
Author: S.D. Bentley
Author: S.N. Faust ORCID iD
Author: S.C. Clarke ORCID iD

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