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Evolution of gait abnormalities in SOD1(G93A) transgenic mice

Evolution of gait abnormalities in SOD1(G93A) transgenic mice
Evolution of gait abnormalities in SOD1(G93A) transgenic mice
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the loss of upper and lower motoneurons. Clinically, it is manifested by weakness, muscle atrophy and progressive paralysis and ends up with patients' death 2-5 years after diagnosis. Although these symptoms lead in many cases to gait deficits in patients, an exhaustive locomotor profile of animal models mimicking the disease has not been assessed yet. In this work we evaluated the locomotor performance of the SOD1(G93A) mouse model of ALS using computerized treadmill gait analysis. SOD1(G93A) mice presented early (8 weeks of age) gait abnormalities, evidenced by an increase in the time of the propulsion phase of hindlimb stance. The alterations progressed during the disease until a complete disturbance of normal gait. This finding is meaningful to the field because the identification of a significant difference in a functional endpoint as early as 8 weeks might be a step forward resolving the debate about treatment of mice prior to the symptomatic phase in efficacy studies. These results also point out that digitizing analysis of treadmill locomotion may be useful to evaluate whether new therapeutic approaches are improving functional outcome of the animals
0006-8993
65-73
Mancuso, Renzo
05786562-a993-4e37-926e-3c1fcf50b36d
Oliván, Sara
c79177db-486c-40cf-af50-9ace055241d0
Osta, Rosario
64007891-e6c1-4242-ab1c-0c5e69276431
Navarro, Xavier
8854ebaa-d283-4d46-829e-c7c8f186585e
Mancuso, Renzo
05786562-a993-4e37-926e-3c1fcf50b36d
Oliván, Sara
c79177db-486c-40cf-af50-9ace055241d0
Osta, Rosario
64007891-e6c1-4242-ab1c-0c5e69276431
Navarro, Xavier
8854ebaa-d283-4d46-829e-c7c8f186585e

Mancuso, Renzo, Oliván, Sara, Osta, Rosario and Navarro, Xavier (2011) Evolution of gait abnormalities in SOD1(G93A) transgenic mice. Brain Research, 1406, 65-73. (doi:10.1016/j.brainres.2011.06.033). (PMID:21733494)

Record type: Article

Abstract

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the loss of upper and lower motoneurons. Clinically, it is manifested by weakness, muscle atrophy and progressive paralysis and ends up with patients' death 2-5 years after diagnosis. Although these symptoms lead in many cases to gait deficits in patients, an exhaustive locomotor profile of animal models mimicking the disease has not been assessed yet. In this work we evaluated the locomotor performance of the SOD1(G93A) mouse model of ALS using computerized treadmill gait analysis. SOD1(G93A) mice presented early (8 weeks of age) gait abnormalities, evidenced by an increase in the time of the propulsion phase of hindlimb stance. The alterations progressed during the disease until a complete disturbance of normal gait. This finding is meaningful to the field because the identification of a significant difference in a functional endpoint as early as 8 weeks might be a step forward resolving the debate about treatment of mice prior to the symptomatic phase in efficacy studies. These results also point out that digitizing analysis of treadmill locomotion may be useful to evaluate whether new therapeutic approaches are improving functional outcome of the animals

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Accepted/In Press date: 12 June 2011
Published date: 11 August 2011
Organisations: Centre for Biological Sciences

Identifiers

Local EPrints ID: 376113
URI: http://eprints.soton.ac.uk/id/eprint/376113
ISSN: 0006-8993
PURE UUID: dc128301-8e0b-479e-ba57-2a25e25973cd

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Date deposited: 24 Apr 2015 08:50
Last modified: 15 Jul 2019 21:23

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