The University of Southampton
University of Southampton Institutional Repository

Lack of a synergistic effect of a non-viral ALS gene therapy based on BDNF and a TTC fusion molecule

Lack of a synergistic effect of a non-viral ALS gene therapy based on BDNF and a TTC fusion molecule
Lack of a synergistic effect of a non-viral ALS gene therapy based on BDNF and a TTC fusion molecule
Significant improvements in behavioral and electrophysiological results, motoneuron survival and anti-apoptotic/survival-activated pathways were observed with BDNF-TTC treatment. However, no synergistic effect was found for this fusion molecule. Although BDNF in the fusion molecule is capable of activating autocrine and neuroprotective pathways, TTC treatment alone yielded similar neuroprotection. Therefore, an accurate study of the neuroprotective effects of TTC fusion molecules should be performed to obtain a better understanding of its effects
1750-1172
10
Calvo, Ana C.
9b59790f-4ab9-4cf5-90ad-2f1384be21fd
Moreno-Igoa, María
335bc20a-91d8-4b07-aa94-881f7a8908b2
Mancuso, Renzo
05786562-a993-4e37-926e-3c1fcf50b36d
Manzano, Raquel
32c51040-8d7f-44d0-9dfd-b505b03fbaf5
Oliván, Sara
c79177db-486c-40cf-af50-9ace055241d0
Muñoz, María J.
3cc32a2d-b68a-4e9c-b7bd-f106fca029b4
Penas, Clara
650c6d8e-5990-4765-9a66-2b43fbfe46a1
Zaragoza, Pilar
c6176a36-77df-48e6-9a59-dad9c9a9932e
Navarro, Xavier
8854ebaa-d283-4d46-829e-c7c8f186585e
Osta, Rosario
64007891-e6c1-4242-ab1c-0c5e69276431
Calvo, Ana C.
9b59790f-4ab9-4cf5-90ad-2f1384be21fd
Moreno-Igoa, María
335bc20a-91d8-4b07-aa94-881f7a8908b2
Mancuso, Renzo
05786562-a993-4e37-926e-3c1fcf50b36d
Manzano, Raquel
32c51040-8d7f-44d0-9dfd-b505b03fbaf5
Oliván, Sara
c79177db-486c-40cf-af50-9ace055241d0
Muñoz, María J.
3cc32a2d-b68a-4e9c-b7bd-f106fca029b4
Penas, Clara
650c6d8e-5990-4765-9a66-2b43fbfe46a1
Zaragoza, Pilar
c6176a36-77df-48e6-9a59-dad9c9a9932e
Navarro, Xavier
8854ebaa-d283-4d46-829e-c7c8f186585e
Osta, Rosario
64007891-e6c1-4242-ab1c-0c5e69276431

Calvo, Ana C., Moreno-Igoa, María, Mancuso, Renzo, Manzano, Raquel, Oliván, Sara, Muñoz, María J., Penas, Clara, Zaragoza, Pilar, Navarro, Xavier and Osta, Rosario (2011) Lack of a synergistic effect of a non-viral ALS gene therapy based on BDNF and a TTC fusion molecule. Orphanet Journal of Rare Diseases, 6 (10), 10. (doi:10.1186/1750-1172-6-10). (PMID:21418619)

Record type: Article

Abstract

Significant improvements in behavioral and electrophysiological results, motoneuron survival and anti-apoptotic/survival-activated pathways were observed with BDNF-TTC treatment. However, no synergistic effect was found for this fusion molecule. Although BDNF in the fusion molecule is capable of activating autocrine and neuroprotective pathways, TTC treatment alone yielded similar neuroprotection. Therefore, an accurate study of the neuroprotective effects of TTC fusion molecules should be performed to obtain a better understanding of its effects

Other
art%3A10.1186%2F1750-1172-6-10.pdf_token2=exp=1429872606~acl=%2Fstatic%2Fpdf%2F499%2Fart%253A10.1186%252F1750-1172-6-10.pdf_~hmac=9798589e7b1a1224ac0295798711fd3d564dca56ab822fdf3d78bc5f576cc8e9 - Version of Record
Available under License Creative Commons Attribution.
Download (3MB)

More information

Published date: March 2011
Organisations: Centre for Biological Sciences

Identifiers

Local EPrints ID: 376116
URI: https://eprints.soton.ac.uk/id/eprint/376116
ISSN: 1750-1172
PURE UUID: e7ae1f36-d805-4855-9892-37b5e9ee4c9d

Catalogue record

Date deposited: 24 Apr 2015 10:35
Last modified: 28 Oct 2019 20:47

Export record

Altmetrics

Contributors

Author: Ana C. Calvo
Author: María Moreno-Igoa
Author: Renzo Mancuso
Author: Raquel Manzano
Author: Sara Oliván
Author: María J. Muñoz
Author: Clara Penas
Author: Pilar Zaragoza
Author: Xavier Navarro
Author: Rosario Osta

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×