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Presenting phenotype of paediatric inflammatory bowel disease (PIBD) in Wessex, southern England 2010-13

Presenting phenotype of paediatric inflammatory bowel disease (PIBD) in Wessex, southern England 2010-13
Presenting phenotype of paediatric inflammatory bowel disease (PIBD) in Wessex, southern England 2010-13
Aim: there has been at least a two-fold increase in the incidence of PIBD over the last 20 years; we report the presenting features from 2010-13 and compare with previous data.

Methods: all patients diagnosed with PIBD at University Hospitals Southampton from 2010-2013 were identified from an in-house database. Data were obtained from paper and electronic notes. Height, Weight and BMI SDS are presented as median values (95% CI).

Results: 172 patients were included (median age at diagnosis 13.5, 115 male); CD- 107, UC- 50, IBDU- 15. The most common presenting features of CD were abdominal pain (86%), diarrhoea (78.5%) and weight loss (56.1%); 42.1% of patients had all three. In UC blood in stool (92%), diarrhoea (92%) and abdominal pain (88%) were the most common; all three in 76% of patients.

CD presented with ileocolonic disease in 52.5%. UC presented with pancolitis in 64%.

There was growth delay in CD: height -0.37(-0.60 to -0.14); Weight -1.09 (-1.35 to -0.83). Growth was maintained in UC: height 0.53 (0.19 to 0.87); weight 0.14 (-0.20 to 0.48).

Conclusion: PIBD phenotype remains as extensive despite increasing incidence. Although the classical phenotype is common a reasonable proportion present with atypical features, normal growth and normal blood markers
0803-5253
831-837
Ashton, J.J.
03369017-99b5-40ae-9a43-14c98516f37d
Coelho, T.
a78b627c-ea78-41e1-9553-0390921e3c93
Ennis, S.
7b57f188-9d91-4beb-b217-09856146f1e9
Batra, A.
734758f2-bd9d-4f61-8696-de0715a0bed6
Afzal, N.A.
5148f35e-6788-4dbd-a50f-c303a4948d60
Beattie, R.M.
977a2f68-2bcf-4436-87e7-28a39952adda
Ashton, J.J.
03369017-99b5-40ae-9a43-14c98516f37d
Coelho, T.
a78b627c-ea78-41e1-9553-0390921e3c93
Ennis, S.
7b57f188-9d91-4beb-b217-09856146f1e9
Batra, A.
734758f2-bd9d-4f61-8696-de0715a0bed6
Afzal, N.A.
5148f35e-6788-4dbd-a50f-c303a4948d60
Beattie, R.M.
977a2f68-2bcf-4436-87e7-28a39952adda

Ashton, J.J., Coelho, T., Ennis, S., Batra, A., Afzal, N.A. and Beattie, R.M. (2015) Presenting phenotype of paediatric inflammatory bowel disease (PIBD) in Wessex, southern England 2010-13. Acta Paediatrica, 104 (8), 831-837. (doi:10.1111/apa.13017).

Record type: Article

Abstract

Aim: there has been at least a two-fold increase in the incidence of PIBD over the last 20 years; we report the presenting features from 2010-13 and compare with previous data.

Methods: all patients diagnosed with PIBD at University Hospitals Southampton from 2010-2013 were identified from an in-house database. Data were obtained from paper and electronic notes. Height, Weight and BMI SDS are presented as median values (95% CI).

Results: 172 patients were included (median age at diagnosis 13.5, 115 male); CD- 107, UC- 50, IBDU- 15. The most common presenting features of CD were abdominal pain (86%), diarrhoea (78.5%) and weight loss (56.1%); 42.1% of patients had all three. In UC blood in stool (92%), diarrhoea (92%) and abdominal pain (88%) were the most common; all three in 76% of patients.

CD presented with ileocolonic disease in 52.5%. UC presented with pancolitis in 64%.

There was growth delay in CD: height -0.37(-0.60 to -0.14); Weight -1.09 (-1.35 to -0.83). Growth was maintained in UC: height 0.53 (0.19 to 0.87); weight 0.14 (-0.20 to 0.48).

Conclusion: PIBD phenotype remains as extensive despite increasing incidence. Although the classical phenotype is common a reasonable proportion present with atypical features, normal growth and normal blood markers

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e-pub ahead of print date: 3 April 2015
Published date: August 2015
Organisations: Cancer Sciences, Human Development & Health, Centre for Biological Sciences

Identifiers

Local EPrints ID: 376405
URI: http://eprints.soton.ac.uk/id/eprint/376405
ISSN: 0803-5253
PURE UUID: 7dd77072-1b7e-480c-8949-23f03cf68f89
ORCID for S. Ennis: ORCID iD orcid.org/0000-0003-2648-0869

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Date deposited: 27 Apr 2015 12:02
Last modified: 20 Jul 2019 01:09

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Contributors

Author: J.J. Ashton
Author: T. Coelho
Author: S. Ennis ORCID iD
Author: A. Batra
Author: N.A. Afzal
Author: R.M. Beattie

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